Abstract:The microRNAs (miRNAs) have been shown to play important roles in the control of many normal biological processes including cell differentiation and organogenesis. During the development of normal pancreas, several miRNAs including miR-375, miR-7, miR-124, etc. have been shown to regulate exocrine and endocrine cell differentiation. These regulations could in part be mediated through the miRNA-mediated deregulation of transforming growth factor-β, Notch, and Hedgehog signaling, which are the signal transductio… Show more
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