Silencing of LncRNA BDNF-AS attenuates Aβ<sub>25-35</sub>-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress

Guo, Congcong; Jiao, Chun-Hong; Gao, Zhen-Mei

doi:10.1080/01616412.2018.1480921

Cited by 57 publications

(33 citation statements)

References 36 publications

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“…The content of ROS and MDA went with the expression of BDNF-AS; inversely, the antioxidant proteins like superoxide dismutase and catalase were strikingly upregulated. Induced by oxidative stress, BDNF-AS performed in decreasing cell viability and increasing cell apoptosis [55].…”

Section: Lncrnas Involving In the Oxidative Stressmentioning

confidence: 99%

Long Noncoding RNAs in the Regulation of Oxidative Stress

Wang

Shen

Zhu

et al. 2019

Oxidative Medicine and Cellular Longevity

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Oxidative stress takes responsibility for various diseases, such as chronic obstructive pulmonary disease (COPD), Alzheimer’s disease (AD), and cardiovascular disease; nevertheless, there is still a lack of specific biomarkers for the guidance of diagnosis and treatment of oxidative stress-related diseases. In recent years, growing studies have documented that oxidative stress has crucial correlations with long noncoding RNAs (lncRNAs), which have been identified as important transcriptions involving the process of oxidative stress, inflammation, etc. and been regarded as the potential specific biomarkers. In this paper, we review links between oxidative stress and lncRNAs, highlight lncRNAs that refer to oxidative stress, and conclude that lncRNAs have played a negative or positive role in the oxidation/antioxidant system, which may be helpful for the further investigation of specific biomarkers of oxidative stress-related diseases.

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Section: Lncrnas Involving In the Oxidative Stressmentioning

confidence: 99%

Long Noncoding RNAs in the Regulation of Oxidative Stress

Wang

Shen

Zhu

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Synthetic Aβ 25–35 also displayed toxic activity in cell culture and ability to form aggregates with properties similar to deposits found in AD patients’ brains. It is often assumed that Aβ 25–35 is a highly neurotoxic fragment of Aβ [ 26 , 27 , 28 , 29 ].…”

Section: Structure and Cascade Of β-Amyloid Transformationsmentioning

confidence: 99%

Interactions of Amyloid-β with Membrane Proteins

Wiatrak

Piasny

Kuźniarski

et al. 2021

IJMS

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In developing and developed countries, an increasing elderly population is observed. This affects the growing percentage of people struggling with neurodegenerative diseases, including Alzheimer’s disease. Nevertheless, the pathomechanism of this disease is still unknown. This contributes to problems with early diagnosis of the disease as well as with treatment. One of the most popular hypotheses of Alzheimer’s disease is related to the pathological deposition of amyloid-β (Aβ) in the brain of ill people. In this paper, we discuss issues related to Aβ and its relationship in the development of Alzheimer’s disease. The structure of Aβ and its interaction with the cell membrane are discussed. Not only do the extracellular plaques affect nerve cells, but other forms of this peptide as well.

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“…Silencing SOX21-AS1 lncRNA has been proposed to alleviate neuronal OS and suppress neuronal apoptosis in AD mice through the upregulation of FZD3/5 and the subsequent activation of the Wnt signaling pathway [152]. Other studies have shown that silencing BDNF-AS [153] and ATB [154] lncRNAs in PC12 neuronal cell model attenuates apoptosis and OS induced by Aβ.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases

et al. 2020

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Oxidative stress (OS) results from an imbalance between the production of reactive oxygen species and the cellular antioxidant capacity. OS plays a central role in neurodegenerative diseases, where the progressive accumulation of reactive oxygen species induces mitochondrial dysfunction, protein aggregation and inflammation. Regulatory non-protein-coding RNAs (ncRNAs) are essential transcriptional and post-transcriptional gene expression controllers, showing a highly regulated expression in space (cell types), time (developmental and ageing processes) and response to specific stimuli. These dynamic changes shape signaling pathways that are critical for the developmental processes of the nervous system and brain cell homeostasis. Diverse classes of ncRNAs have been involved in the cell response to OS and have been targeted in therapeutic designs. The perturbed expression of ncRNAs has been shown in human neurodegenerative diseases, with these changes contributing to pathogenic mechanisms, including OS and associated toxicity. In the present review, we summarize existing literature linking OS, neurodegeneration and ncRNA function. We provide evidences for the central role of OS in age-related neurodegenerative conditions, recapitulating the main types of regulatory ncRNAs with roles in the normal function of the nervous system and summarizing up-to-date information on ncRNA deregulation with a direct impact on OS associated with major neurodegenerative conditions.

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Silencing of LncRNA BDNF-AS attenuates Aβ_25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress

Abstract: Aβ: amyloid beta peptide 25-35; AD: Alzheimer's disease; LncRNA BDNF-AS: long non-coding RNA brain-derived neurotrophic factor anti-sense; OS: Oxidative stress.

Cited by 57 publications

References 36 publications

Long Noncoding RNAs in the Regulation of Oxidative Stress

Long Noncoding RNAs in the Regulation of Oxidative Stress

Interactions of Amyloid-β with Membrane Proteins

Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases

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Silencing of LncRNA BDNF-AS attenuates Aβ25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress

Abstract: Aβ: amyloid beta peptide 25-35; AD: Alzheimer's disease; LncRNA BDNF-AS: long non-coding RNA brain-derived neurotrophic factor anti-sense; OS: Oxidative stress.

Cited by 57 publications

References 36 publications

Long Noncoding RNAs in the Regulation of Oxidative Stress

Long Noncoding RNAs in the Regulation of Oxidative Stress

Interactions of Amyloid-β with Membrane Proteins

Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases

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Product

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Silencing of LncRNA BDNF-AS attenuates Aβ_25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress