Silencing of amygdala circuits during sepsis prevents the development of anxiety-related behaviours

Bourhy, Lena; Mazeraud, Aurélien; Costa, Luís Henrique Angenendt da; Levy, Jarod; Rei, Damien; Hecquet, Estéban; Gabanyi, Ilana; Bozza, Fernando A.; Chrétien, Fabrice; Lledo, Pierre−Marie; Sharshar, Tarek; Lepousez, Gabriel

doi:10.1093/brain/awab475

Cited by 11 publications

(11 citation statements)

References 95 publications

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“…There is also evidence showing that changes within CeA circuit are implicated in inflammatory-related mental disease. For example, a recent study showed that in a mouse model of sepsis induced by intraperitoneal infection, the mice exhibited anxiety-like behavior and exaggerated fear memories, which are similar to anxiety and PTSD-like symptoms seen in human sepsis survivors [ 155 ]. It was found that sepsis induces the acute pathological activation of CeA-specific neuron types that project to the ventral BNST and transient and targeted silencing of this subpopulation using chemogenetic methods during the acute phase of sepsis can prevent the subsequent development of anxiety-related behaviors [ 155 ].…”

Section: Amygdala Neuroinflammation and Psychiatric Disordersmentioning

confidence: 99%

“…For example, a recent study showed that in a mouse model of sepsis induced by intraperitoneal infection, the mice exhibited anxiety-like behavior and exaggerated fear memories, which are similar to anxiety and PTSD-like symptoms seen in human sepsis survivors [ 155 ]. It was found that sepsis induces the acute pathological activation of CeA-specific neuron types that project to the ventral BNST and transient and targeted silencing of this subpopulation using chemogenetic methods during the acute phase of sepsis can prevent the subsequent development of anxiety-related behaviors [ 155 ]. Considering inflammatory chronic pain increases the risk of depression, Zhou and colleagues identified a novel pathway involving 5-HT projections from the dorsal raphe nucleus to somatostatin-expressing interneurons in the CeA, and then to the lateral habenula for comorbid depressive symptoms in chronic pain [ 156 ].…”

Section: Amygdala Neuroinflammation and Psychiatric Disordersmentioning

confidence: 99%

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New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

Pan

et al. 2022

IJMS

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Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect hundreds of millions of individuals worldwide. Understanding the etiology and related mechanisms is of great importance and might yield new therapeutic strategies to treat these diseases effectively. During the past decades, a growing number of studies have pointed out the importance of the stress-induced inflammatory response in the amygdala, a kernel region for processing emotional stimuli, as a potentially critical contributor to the pathophysiology of depression and anxiety disorders. In this review, we first summarized the recent progress from both animal and human studies toward understanding the causal link between stress-induced inflammation and depression and anxiety disorders, with particular emphasis on findings showing the effect of inflammation on the functional changes in neurons in the amygdala, at levels ranging from molecular signaling, cellular function, synaptic plasticity, and the neural circuit to behavior, as well as their contributions to the pathology of inflammation-related depression and anxiety disorders. Finally, we concluded by discussing some of the difficulties surrounding the current research and propose some issues worth future study in this field.

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Section: Amygdala Neuroinflammation and Psychiatric Disordersmentioning

confidence: 99%

Section: Amygdala Neuroinflammation and Psychiatric Disordersmentioning

confidence: 99%

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

Pan

et al. 2022

IJMS

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“…Optogenetic stimulation of CeA→basolateral amygdala circuits can induce these behaviors (Tye et al, 2011), but based on our tracing studies, these are distinct from AVPR1A CeA neurons. Chemogenetic inhibition of CeA→BNST circuits prevents anxiety-related behavioral adaptations in the context of sepsis (Bourhy et al, 2022). Since they did not target their manipulations to a genetically defined subpopulation of neurons, it is possible that some AVPR1A CeA neurons contributed to this effect.…”

Section: Discussionmentioning

confidence: 99%

Amygdala AVPR1A mediates susceptibility to chronic social isolation in females

François

Delgado

Lafond

et al. 2023

Preprint

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Females are more sensitive to social exclusion, which could contribute to their heightened susceptibility to anxiety disorders. Chronic social isolation stress (CSIS) for at least 7 weeks after puberty induces anxiety-related behavioral adaptations in female mice. Here, we show that Arginine vasopressin receptor 1a (Avpr1a)-expressing neurons in the central nucleus of the amygdala (CeA) mediate these sex-specific effects, in part, via projections to the caudate putamen. Loss of function studies demonstrate that AVPR1A signaling in the CeA is required for effects of CSIS on anxiety-related behaviors in females but has no effect in males or group housed females. This sex-specificity is mediated by AVP produced by a subpopulation of neurons in the posterodorsal medial nucleus of the amygdala that project to the CeA. Estrogen receptor alpha signaling in these neurons also contributes to preferential sensitivity of females to CSIS. These data support new therapeutic applications for AVPR1A antagonists in women.

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“…Gut-innervating nociceptors can be activated by Salmonella enterica and release a neuropeptide that modulates both the density of Peyer patches’ M cells and the levels of segmentous filamented bacteria, leading to a protection against infection ( 51 ). A specific neuronal population of the central nucleus of the amygdala was found to be activated in the brain of mice recovering from experimental sepsis, leading to anxiety-related behavior and exaggerated fear memory similar to the long-term anxiety and post-traumatic stress disorder-like syndrome observed following sepsis in humans ( 52 ).…”

Section: Crosstalk Between the Two Systems Of Relationmentioning

confidence: 92%

The immune system as a system of relations

Daëron

2022

Front. Immunol.

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Progress in neuroimmunology established that the nervous and the immune systems are two functionally related physiological systems. Unique sensory and immune receptors enable them to control interactions of the organism with the inner and the outer worlds. Both systems undergo an experience-driven selection process during their ontogeny. They share the same mediators/neurotransmitters and use synapses for intercellular communication. They keep a memory of previous experiences. Immune cells can affect nervous cells, nervous cells can affect immune cells, and they regulate each other. I however argue that the two systems differ by three major points: 1) Unlike the nervous system, the immune system has a loose anatomical structure, in which molecular and cellular events mostly occur at random; 2) The immune system can respond to molecules of the living world whereas the nervous system can respond to phenomena of the physical world; 3) Responses of the immune system act both on the organism and on the stimulus that triggered the response, whereas responses of the nervous system act on the organism only. The nervous and the immune systems therefore appear as two complementary systems of relations that closely work together, and whose reactivities are well-suited to deal with physical and biological stimuli, respectively. Its ability both to adapt the organism to the living world and to adapt the living world to the organism endows the immune system with powerful adaptive properties that enable the organism to live in peace with itself and with other living beings, whether pathogens or commensals.

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Silencing of amygdala circuits during sepsis prevents the development of anxiety-related behaviours

Cited by 11 publications

References 95 publications

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

Amygdala AVPR1A mediates susceptibility to chronic social isolation in females

The immune system as a system of relations

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