Sildenafil Sebagai Pilihan Terapi Hipertensi Pulmonal Pascabedah Jantung Koreksi Penyakit Jantung Bawaan pada Anak

Prawira, Yogi; Yanuarso, Piprim B.

doi:10.14238/sp11.6.2010.456-462

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…In addition to providing minimal side effects, sildenafil is also sold for an affordable price. In a study of 25 children with PAH associated with chronic lung disease (including bronchopulmonary dysplasia, CHD, PPHN, and pulmonary hypoplasia), 88% showed improvement in echocardiographic measurements of pulmonary hypertension (HP) after a mean duration of sildenafil treatment of 40 days [30,31].…”

Section: Pah Spesific Treatmentmentioning

confidence: 99%

Characteristics Of Pulmonary Arterial Hypertension in Children with Acyanotic Congenital Heart Disease

Imanina¹,

Hidayat²,

Sembiring³

et al. 2021

IJRP

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Background: Congenital heart disease is the leading cause of death in infants related to birth defects and can cause chronic defects [1]. The most common complication is pulmonary hypertension (PH). The worst manifestation of PAH is Eisenmenger syndrome. If it has manifested into Eisenmenger syndrome, the defect in CHD cannot be corrected [2,3]. Research on the characteristics of PAH in CHD needs to be known for better treatment. Methods: This is a descriptive study in pediatric patients with acyanotic congenital heart disease. In this research we used medical records. Data analysis was carried out descriptively. Results:The results of this study showed that the prevalence of PAH was 7.08%, and most of the patients were toddlers (33 patients or 57.9%) and female (38 patients of 66.7%). The most common diagnosis of CHD lesions was ASD, found in 19 patients (33.3%). Most patients came with severe PAH conditions. Pharmacological therapy in the form of sildenafil was mostly given. The most common symptoms were shortness of breath and murmurs on physical examination. There was no relationship between intervention variables, pharmacological therapy, and mortality and between diagnosis of CHD and severity of PAH. Conclusion: Although the prevalence of PAH was not high in this study, the mortality rate was quite high. It is necessary to educate the parents of patients with congenital heart disease so that further complications can be prevented early on. It is also necessary to make services better to improve the nutritional status of patients. Pharmacological therapy and intervention measures need to be reviewed and improved to reduce mortality in patients.

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Section: Pah Spesific Treatmentmentioning

confidence: 99%

Characteristics Of Pulmonary Arterial Hypertension in Children with Acyanotic Congenital Heart Disease

Imanina¹,

Hidayat²,

Sembiring³

et al. 2021

IJRP

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“…This can be associated with congenital heart diseases such as the right to left shunt through the foramen ovale (PFO) or patent ductus arteriosus (PDA) due to an error in the transition of fetal blood circulation to the neonate (Park & Chung, 2017). This condition is caused by pulmonary artery pressure or pulmonary vein with a mean pulmonary artery pressure (PAP) > 25 mmHg at rest or > 30 mmHg during activity (Prawira & Yanuarso, 2016). The PPHN classification includes 3 categories, namely mild PPHN (PASP 36-45 mmHg), moderate PPHN (PASP 45-60 mmHg), and severe PPHN (PASP > 60 mmHg) (de Boode et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Association between gestational age and persistent pulmonary hypertension of the newborn (PPHN) severity in preterm babies at Sidoarjo Regional Hospital

et al. 2021

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Persistent pulmonary hypertension of the newborn (PPHN) is a condition that occurs due to increased resistance to blood vessels in the lungs that occur persistently after the baby is born. This can be attributed to congenital heart disease such as right-to-left shunts through foramen ovale (PFO) or patent ductus arteriosus (PDA) due to an error transition fetal blood circulation to the neonate. Although PPHN is always associated with births in post-term babies, PPHN cases are often found in preterm babies. Chances of babies born with PPHN are quite large, at 1.9% per 1000 live births. PPHN can be fatal, causing mortality rates ranging from 4 to 33%. The incidence of preterm births in Indonesia is estimated at 7-14%, around 459,200 - 900,000 babies per year. This study aimed to prove the relationship between premature babies and persistent pulmonary hypertension of the newborn (pphn) in Sidoarjo Regional Hospital and to know the characteristics and analyze these variables. This research used crossed sectional studied design; the population was all preterm babies in the NICU at Sidoarjo regional hospital. All samples are from medical records in January-December 2018. There is a significant difference between preterm babies and PPHN (p < 0.05); besides, the results from Spearman's correlation analysis obtained a correlation coefficient (ρ) = 0.485. In the cross-tabulation analysis, the result of the proportion with the highest correlation was Late Preterm babies with severe PPHN of 46.7%. It can be concluded that there is a relationship between premature babies and PPHN in Sidoarjo regional hospital..Keywords : Persistent pulmonary hypertension of the newborn, PPHN, Preterm BabiesCorrespondence : aisyahhelmadevithalib@gmail.com

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“…Pulmonary arterial hypertension (PAH) is a disease characterized by a mean pulmonary artery pressure of more than 25 mmHg at rest [1–3]. In normal conditions, mean pulmonary artery pressure is usually between 8 and 20 mmHg [4].…”

Section: Introductionmentioning

confidence: 99%

Economic evaluation of sildenafil for the treatment of pulmonary arterial hypertension in Indonesia

Lilyasari

Subekti²,

Atika³

et al. 2019

BMC Health Serv Res

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Background This study aims to assess the cost-effectiveness and budget impact of adopting sildenafil to the benefits package for the indication of pulmonary arterial hypertension (PAH), compared to beraprost. Methods Based on a societal perspective, a model-based economic evaluation was performed using local and international data to quantify the potential costs and health-related outcomes in terms of life years (LYs) and quality-adjusted life years (QALYs). Results The economic model calculated the incremental cost-effectiveness ratio (ICER) per QALY gained for using sildenafil as first-line therapy compared to beraprost for the patient in functional class (FC) II and III, i.e. USD 3098 and USD 2827, respectively. The results indicated that in spite of sildenafil being more expensive than beraprost, generic sildenafil could potentially be a good value for money since ICER per QALY is below one times gross domestic product (GDP) per capita in Indonesia. Furthermore, budget impact analysis estimated that the incremental budget needed within 5 years for including sildenafil compared to beraprost for PAH patients starting in FC II and FC III was USD 436,775 and USD 3.6 million, respectively. Conclusions Compared to beraprost, sildenafil would be preferable for the treatment of PAH patients in FC II and FC III in Indonesia. The additional budget for adopting sildenafil compared to beraprost as the treatment of PAH in the benefits package was estimated at around USD 4.0 million. Electronic supplementary material The online version of this article (10.1186/s12913-019-4422-5) contains supplementary material, which is available to authorized users.

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Sildenafil Sebagai Pilihan Terapi Hipertensi Pulmonal Pascabedah Jantung Koreksi Penyakit Jantung Bawaan pada Anak

Cited by 3 publications

References 17 publications

Characteristics Of Pulmonary Arterial Hypertension in Children with Acyanotic Congenital Heart Disease

Characteristics Of Pulmonary Arterial Hypertension in Children with Acyanotic Congenital Heart Disease

Association between gestational age and persistent pulmonary hypertension of the newborn (PPHN) severity in preterm babies at Sidoarjo Regional Hospital

Economic evaluation of sildenafil for the treatment of pulmonary arterial hypertension in Indonesia

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