Sildenafil Citrate (Viagra) Enhances Vasodilatation in Fetal Growth Restriction

Wareing, Mark; Myers, Jenny; O’Hara, Maureen; Baker, Philip N.

doi:10.1210/jc.2004-1831

Cited by 157 publications

(105 citation statements)

References 38 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…In FGR and PET, there is decreased depth and density of trophoblast invasion 6,7 and myometrial small arteries show increased vasoconstriction and decreased endothelium-dependent vasodilatation. 8,9 Vascular endothelial growth factor is essential for angiogenesis during development. 10 Vascular endothelial growth factor (VEGF) gene or protein therapy may prove therapeutically useful in local perivascular applications by stimulating vascular-protective endothelial functions.…”

mentioning

confidence: 99%

Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep

et al. 2008

View full text Add to dashboard Cite

mentioning

confidence: 99%

Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep

et al. 2008

View full text Add to dashboard Cite

“…Again, this agrees with our work. Also, Lin et al [21] reported a decrease in uterine artery pulsatility and resolution of uterine artery notching following administration of sildenafil citrate to a case of IUGR diagnosed at 26 weeks of gestations. Contradictory to our findings, they also observed increase in EFW without maternal or neonatal adverse outcomes.…”

Section: Statistical Analysis Of the Datamentioning

confidence: 99%

The use of low dose sildenafil citrate in cases of intrauterine growth restriction

Mohammed¹,

Alashkar²,

Abdeldayem³

et al. 2017

Clin Obstet Gynecol Reprod Med

View full text Add to dashboard Cite

Introduction: Intrauterine growth restriction [IUGR] is defined as a birth weight less than the 10th percentile for gestational age. It has a prevalence of the 5-8% in the general population. It represents the second cause of perinatal mortality, after prematurity. Sildenafil citrate is a phosphodiesterase5 (PDE-5) inhibitor, delaying the breakdown of cyclic guanosine monophosphate (cGMP) and enhancing nitric oxide (NO)-dependent vasodilatation. Sildenafil citrate is increasingly used for pulmonary hypertension in pregnancy, and is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for premature labour.

show abstract

“…Because of the importance of placental blood flow to placental function, and the recognition that placental size, uteroplacental blood flows and angiogenesis, and expression of angiogenic and vasoactive factors are reduced or altered in compromised pregnancies, it has been suggested that therapeutic agents that target placental blood flow and vascular development could be used to ameliorate fetal growth restriction (Godfrey, 2002;Ahmad and Ahmed, 2005;Wu et al, 2004;Wareing et al, 2005;Reynolds et al, 2006).…”

Section: 'Rescue' Of Placental Angiogenesis and Blood Flow In Comprommentioning

confidence: 99%

Uteroplacental vascular development and placental function: an update

Reynolds¹,

Borowicz²,

Caton³

et al. 2010

Int. J. Dev. Biol.

158

113

View full text Add to dashboard Cite

The importance of the placenta and its vascular development to fetal growth and development has been appreciated since ancient times. Based on numerous studies in humans and animal model organisms in the last 2-3 decades, normal placental angiogenesis is critically important to ensure adequate blood flow to the placenta and therefore to provide the substrates that support normal fetal growth. Placental angiogenesis is abnormal at term in compromised pregnancies (those in which fetal growth is altered), including those resulting from maternal nutritional or environmental stress, maternal age, increased numbers of fetuses, maternal or fetal genotype, or the use of assisted reproductive technologies (e.g., cloning by somatic cell nuclear transfer). We and others have recently shown that these defects in placental vascular development occur quite early in pregnancy and may therefore presage compromised fetal growth and development. The challenges will be to find biomarkers of abnormal placental angiogenesis and to develop therapeutic strategies to "rescue" placental vascular development and thus fetal growth in compromised pregnancies. Animal models will be essential in meeting these challenges.

show abstract

Sildenafil Citrate (Viagra) Enhances Vasodilatation in Fetal Growth Restriction

Abstract: We conclude that sildenafil citrate improves endothelial function of myometrial vessels from women whose pregnancies are complicated by intrauterine growth restriction. Sildenafil citrate may offer a potential therapeutic strategy to improve uteroplacental blood flow in FGR pregnancies.

Cited by 157 publications

References 38 publications

Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep

Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep

The use of low dose sildenafil citrate in cases of intrauterine growth restriction

Uteroplacental vascular development and placental function: an update

Contact Info

Product

Resources

About