Introduction: Intrauterine growth restriction [IUGR] is defined as a birth weight less than the 10th percentile for gestational age. It has a prevalence of the 5-8% in the general population. It represents the second cause of perinatal mortality, after prematurity. Sildenafil citrate is a phosphodiesterase5 (PDE-5) inhibitor, delaying the breakdown of cyclic guanosine monophosphate (cGMP) and enhancing nitric oxide (NO)-dependent vasodilatation. Sildenafil citrate is increasingly used for pulmonary hypertension in pregnancy, and is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for premature labour.
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