Sildenafil: A 4-year update in the treatment of 20 million erectile dysfunction patients

Carson, Culley C.

doi:10.1007/s11934-003-0031-1

Cited by 33 publications

(23 citation statements)

References 46 publications

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“…1,3 Many East Asian countries, excluding Japan, have officially approved doses of sildenafil of up to 100 mg. The dose in Japan has been regulated by the result of a clinical trial for the efficacy of sildenafil, which failed to demonstrate the superiority of 100 to 50 mg. 18 In addition, in our current study, 90% of responders achieved efficacy with 25 or 50 mg of sildenafil.…”

Section: Discussionmentioning

confidence: 99%

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Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

et al. 2005

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The approved maximal dose of sildenafil is only 50 mg in Japan, but the impact of dose regulation on treatment outcomes has not been established. Moreover, the contributors to the efficacy in patients having an intact peripheral nervous system have not been fully elucidated. We assessed in Japanese patients the treatment outcomes of sildenafil for erectile dysfunction (ED) under regulation of the approved dose and identified factors contributing to its efficacy among those with various etiologies other than pelvic surgery. We retrospectively reviewed 196 ED patients treated with sildenafil. The overall efficacy was 70.9% (139/196), and patients with psychological problems and concomitant cardiovascular disease showed high response rates (82.4 and 87.0%, respectively). Of the 139 responders, 89.9% achieved efficacy with a dose of 25 or 50 mg. Logistic regression analysis revealed concomitant cardiovascular disease and a favorable nocturnal penile tumescence result to be independent contributors to the efficacy.

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Section: Discussionmentioning

confidence: 99%

“…For example, post-radical pelvic surgery and severe diabetes respond poorly to sildenafil. 3 Additionally, the efficacy is dose-dependent; 100 mg was more effective than 50 mg. 1 In Japan, the officially approved dose is up to 50 mg, which is in contrast to other Asian countries, where 100 mg is available.…”

Section: Introductionmentioning

confidence: 99%

Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

et al. 2005

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“…3,4 In addition, it was utilized to increase feto placental perfusion in pregnancy, to aid in vitro fertilization, to prevent preeclampsia 5 to treat pulmonary arterial hypertension 6 and in cellulite and skin aging formulae. 7 However, oral administration of SC encounters numerous obstacles.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Sildenafil Citrate Loaded Transfersomes as a Carrier for Transdermal Drug Delivery

Sayyad¹

2017

PPIJ

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The aim of this study was to enhance the transdermal delivery of Sildenafil Citrate by encapsulation in nano sized ultra deformable vesicles, transfersomes. The thin film hydration and sonication technique was utilized in the preparation of Sildenafil Citrate loaded Transfersomes and both non ionic and ionic edge activators (anionic and cationic) were used in varying ratios to study their effects on the physicochemical characteristics and the release properties of the prepared formulations. Results revealed that the mean size of the prepared Sildenafil Citrate loaded nano vesicles ranged from 69.08nm to 265.80nm, the encapsulation efficiencies ranged from 59.90% to 92.49% and the in vitro drug release through synthetic membranes ranged from 40.21% to 99.99%. All formulations were subjected to rank order based on their physicochemical characteristics and in vitro release profiles. Transmission Electron Microscope imaging of the chosen formulations revealed the general images of transfersomes formulations and the predicted differences between the formulations. Results for the ex vivo release of the chosen formulations through isolated skin of rats ranged from 76.29% to 99.90% of the applied dose. Stability studies for the chosen formulations showed that formulations were generally stable. Rotary evaporation and sonication method was found to give more stable Transfersomes. Keywords10 Hence this technique was chosen for formulation development and batch processing. Table 1 shows the composition of the Transfersomal formulae containing SC prepared by thin film hydration technique. Formulations of SC-TS from 1 to 8 were prepared by weight ratios while formulae SC-aTS from 1 to 3 and formulae SC-cTS from 1 to 3 were prepared by molar ratios. The amounts of SLS in formulae SC-aTS were written in mgs which were equivalent to 0.27, 0.29 and 0.31mM of SLS (7.7, 8.0 and 8.9mgs). Also, the amounts of Cet in formulae SC-cTS were written in mgs which were equivalent to 0.27, 0.29 and 0.31mM of Cet (9.8, 10.5 and 11. mgs). The thin film hydration and sonication method was employed as described by El Zaafarany GM et al., 11Jain S.12 The amount of PL, the edge activators (T 80, S 80, SLS and Cet) and SC as a drug were accurately weighed and dissolved in 1:1 mixture of chloroform and methanol. The mixture was sonicated for one minute with probe sonicator (Qsonica, model Q125, Qsonica LLC., USA) to ensure complete dissolution of all components. The resultant ivory yellow clear solution was transferred to the egg plant shaped round bottom flask of the rotary evaporator (Heidolph, model WB2000, Heidolph co., Germany) which was previously cleaned and oven dried. The temperature of the water bath was adjusted to 45°C which is about 10 degrees above the transition temperature of the phospholipids component (32 °C). The rotor speed was adjusted to 60rpm. Complete removal of the organic solvent was accomplished after 45 minutes resulting in a homogenously distributed thin film on the wall of the flask. The flask was kept under va...

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“…Very few placebo-controlled studies of sildenafil have examined objective measures of the drug's effectiveness. For example, the majority of studies investigating the clinical efficacy of sildenafil in ED have used standardized, selfreported measures of erectile function as study endpoints (Carson, 2003). One randomized, double-blind, placebocontrolled crossover study of sildenafil in men with ED used circumferential penile plethysmography to test whether sildenafil could increase the mean duration of erections with C60% rigidity (Gingell, Sultana, Wulff, & Gepi-Attee, 2004).…”

Section: Discussionmentioning

confidence: 99%

Effect of Sildenafil on Penile Plethysmography Responding: A Pilot Investigation

et al. 2009

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Despite the utility of penile plethysmography in helping diagnose sexual offenders, some men respond minimally to the test stimuli. This pilot investigation examined the effect of sildenafil on phallometric responding in a non-forensic sample (n = 12) of middle-aged males. Participants underwent phallometric testing on two separate occasions and were administered 50 mg of sildenafil prior to one of these sessions. Study data indicated that pre-treatment with sildenafil produced a significant mean percentage increase (28%) in peak response compared with the untreated condition. The implication of this result is discussed in view of the selected sample.

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Sildenafil: A 4-year update in the treatment of 20 million erectile dysfunction patients

Cited by 33 publications

References 46 publications

Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

Fabrication and Characterization of Sildenafil Citrate Loaded Transfersomes as a Carrier for Transdermal Drug Delivery

Effect of Sildenafil on Penile Plethysmography Responding: A Pilot Investigation

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