Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

Kobayashi, Ko; Hisasue, Shin‐ichi; Kato, Ryuichi; Shimizu, Takashi; Hashimoto, Kimio; Yamashita, Nana; Itoh, Naoki; Tsukamoto, Taiji

doi:10.1038/sj.ijir.3901400

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…As far as we know, there has been no previous report on the association between responsiveness to PDE5 inhibitor and MS. Our results show a lower response rate for sildenafil in patients with MS, which was 40%, while previous Japanese reports showed that it was about 70% in general patients [24,25]. Moreover, we revealed that the response rate significantly decreased as the number of MS components increased.…”

Section: Discussioncontrasting

confidence: 62%

Negative Impact of Metabolic Syndrome on the Responsiveness to Sildenafil in Japanese Men

Suetomi

Kawai

Hinotsu

et al. 2008

The Journal of Sexual Medicine

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Introduction Several recent studies suggested that the prevalence of erectile dysfunction (ED) was higher in men with metabolic syndrome (MS). Aim We analyzed the impact of MS on the responsiveness to sildenafil. Methods A total of 133 ED patients were evaluated for the prevalence of MS and graded on severity of ED. MS was diagnosed according to the International Diabetes Federation (IDF) definition. The severity of ED was evaluated by the International Index of Erectile Function (IIEF) questionnaire. Hormonal parameters were measured for all patients, and the IIEF questionnaire was conducted after administration of eight tablets of 50-mg doses of sildenafil. If the scores to questions 3 and 4 of the IIEF were 4 or higher after administration, the patients were defined as responders to sildenafil. Main Outcome Measures To clarify the negative impact of MS on the responsiveness to sildenafil. Results The mean age of the patients was 56.9 years, and 25 patients were diagnosed with MS. The IIEF-erectile function score and the response rate for sildenafil decreased as the number of MS components increased. Logistic regression analysis showed that the presence of MS along with severity of ED and history of pelvic surgery were significant independent risk factors of nonresponse for sildenafil. The hazard ratio for the presence of MS was 3.30 (95% confidence interval [CI]: 1.17–9.73). No meaningful association was observed between total testosterone or free testosterone levels and MS in this population. Conclusion We demonstrated the negative impact of MS on the responsiveness to sildenafil. Erectile function and response rate for sildenafil decreased as the number of MS components increased.

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Section: Discussioncontrasting

confidence: 62%

Negative Impact of Metabolic Syndrome on the Responsiveness to Sildenafil in Japanese Men

Suetomi

Kawai

Hinotsu

et al. 2008

The Journal of Sexual Medicine

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“…Suetomi et al analyzed the impact of MS on the responsiveness to 50-mg sildenafil in Japanese patients with ED. They reported a lower response rate for patients with MS, compared with the overall efficacy in Japanese ED patients (40% vs. 70.9%, respectively) [18,19]. The IIEF-erectile function score and the response rate for sildenafil decreased as the number of MS components increased.…”

Section: Negative Impact Of Metabolic Syndrome On the Responsiveness mentioning

confidence: 98%

Cardiovascular Aspects of Sexual Medicine

Jackson

Montorsi

Adams

et al. 2010

The Journal of Sexual Medicine

103

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Introduction Erectile dysfunction (ED) is common and considered to be predominantly of vascular origin. Aim To evaluate the link between ED and coronary artery disease (CAD) and provide a consensus report regarding evaluation and management. Methods A committee of eight experts from six countries was convened to review the worldwide literature concerning ED and CAD and provide a guideline for management. Main Outcome Measure Expert opinion was based on grading the evidence-based medical literature, widespread internal committee discussion, public presentation, and debate. Results ED and CAD frequently coexist. Between 50–70% of men with CAD have ED. ED can arise before CAD is symptomatic with a time window of 3–5 years. ED and CAD share the same risk factors, and endothelial dysfunction is the common denominator. Treating ED in cardiac patients is safe, provided that their risks are properly evaluated. Conclusion ED is a marker for silent CAD that needs to be excluded. Men with CAD frequently have ED that can be treated safely following guidelines.

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“…The drug has been well accepted internationally, and its efficacy is as high as 70–80% . PDE5i is reported to be highly effective for achieving sufficient erection for sexual intercourse in vasculogenic ED patients, which is the most prevalent type of ED among middle‐aged men, although more than 10% of patients are refractory to the treatment . Diabetic ED is less responsive to PDE5i, and it depends on the severity.…”

Section: Introductionmentioning

confidence: 99%

Impact of aging and comorbidity on the efficacy of low‐intensity shock wave therapy for erectile dysfunction

et al. 2015

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Abbreviations & Acronyms ED = erectile dysfunction EHS = erection hardness score LI-SWT = low-intensity shock wave therapy MPCC = mean penile circumferential change NO = nitric oxide PDE5i = phosphodiesterase type-5 inhibitor SHIM = sexual health inventory for men SRE = sleep-related erection VEGF = vascular endothelial growth factor Objectives: To evaluate the efficacy of low-intensity shock wave therapy and to identify the predictive factors of its efficacy in Japanese patients with erectile dysfunction. Methods: The present study included 57 patients with erectile dysfunction who satisfied all the following conditions: more than 6-months history of erectile dysfunction, sexual health inventory for men score of ≤12 without phosphodiesterase type-5 inhibitor, erection hardness score grade 1 or 2, mean penile circumferential change by erectometer assessing sleep related erection of <25 mm and non-neurological pathology. Patients were treated by a low-energy shock waves generator (ED1000; Medispec, Gaithersburg, MD, USA). A total of 12 shock wave treatments were applied. Sexual health inventory for men score, erection hardness score with or without phosphodiesterase type-5 inhibitor, and mean penile circumferential change were assessed at baseline, 1, 3 and 6 months after the termination of low-intensity shock wave therapy. Results: Of 57 patients who were assigned for the low-intensity shock wave therapy trial, 56 patients were analyzed. Patients had a median age of 64 years. The sexual health inventory for men and erection hardness score (with and without phosphodiesterase type-5 inhibitor) were significantly increased (P < 0.001) at each timepoint. The mean penile circumferential change was also increased from 13.1 to 20.2 mm after low-intensity shock wave therapy (P < 0.001). In the multivariate analysis, age and the number of concomitant comorbidities were statistically significant predictors for the efficacy. Conclusions: Low-intensity shock wave therapy seems to be an effective physical therapy for erectile dysfunction. Age and comorbidities are negative predictive factors of therapeutic response.

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Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

Cited by 6 publications

References 31 publications

Negative Impact of Metabolic Syndrome on the Responsiveness to Sildenafil in Japanese Men

Negative Impact of Metabolic Syndrome on the Responsiveness to Sildenafil in Japanese Men

Cardiovascular Aspects of Sexual Medicine

Impact of aging and comorbidity on the efficacy of low‐intensity shock wave therapy for erectile dysfunction

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