Silatranes and Their Tricyclic Analogs

Synthesis, structure and muscarinic agonist activity of substituted N‐(silatran‐1‐ylmethyl)acetamides

“…Similar signals within the range typical for silatranes [1] were observed for MeSi(OCHMeCH 2 ) 3 N and ICH 2 Si(OCHMeCH 2 ) 3 N (−64.2, −66.2 ppm and −78.0, −80.2 ppm, respectively). [16] The chemical shifts in the 29 Si NMR spectra of silatranes 2a,b indicate the absence of additional O → Si coordination in both compounds.…”

“…In recent years, the chemistry [1] and diverse biological activity [2 -4] of silatranes have attracted considerable interest. It was found that carbofunctional aliphatic derivatives of silatranes intensify the biosynthesis of proteins, contribute to the growth and regeneration of connective and epithelial tissue, prevent the development of atherosclerosis and stomach ulcers in animals, and demonstrate neurotropism and antitumor effects [3,4] .…”

Electron Transfer and Modification of Oligosilanylsilatranes and Related Derivatives

“…Both experiment and calculations in AN are thus in agreement with the character of hypercoordination at Si 2 , implying that a longer N–Si distance (and a shorter (N→)Si–Si(1) length) should be observed in case of the atrane-localized oxidation (weakening N→Si interaction), while oxidation on the oligosilanyl substituent would shorten this distance, similarly to the effect of acceptor substituents at Si. 2,3 …”

Tuning the Si–N Interaction in Metalated Oligosilanylsilatranes

“…2 X-ray diffraction studies of silatranes with comparably electronegative halogen, aryl, alkyl, and O substituents indicate a range of Si–N distances from 2.05 to 2.20 Å, 2 which is significantly shorter than the sum of the van der Waals radii of silicon and nitrogen but slightly longer than the typical covalent Si–N single bond distance. 2 Not much is known about silatranes with more electropositive substituents, and examples of metalated silatranes are restricted to a single platinum 7 and a small number of osmium 8−10 complexes.…”