Synthesis, structure and muscarinic agonist activity of substituted N‐(silatran‐1‐ylmethyl)acetamides

1-(Methylaminomethyl)silatrane: Synthesis, characterization and reactivity

“…To date, only crystal structures of N-(silatranylmethyl)amides (A) [41,42], -imides (B) [43,44] and N-(silatranylmethyl) substituted five-membered aromatic heterocycles (C) (derivatives of pyrrole, indole, pyrazole, imidazole, triazole and carbazole) [45e55] with geminal fragment NeCeSi have been described in the literature. Amongst the N-(silatranylmethyl)amines of row RR 0 NCH 2 Si(OCH 2 CH 2 ) 3 N (D) (R, R 0 ¼ H, Alk, Ar) only the single crystal structure of trimethyl(1-silatranylmethyl)ammonium iodide has been studied [56] (Scheme 5).…”

New atranes and similar ionic complexes. Synthesis, structure, properties

“…Later, metallatranes (MA) N (CH 2 CH 2 O) 3 M‐X, (M = Ge, Sn, etc.) were obtained . Due to the transannular intramolecular bond N → M, these molecules have a unique tricyclic structure (Figure a).…”