Signs of the presence of Th17 cells in chronic periodontal disease

Adibrad, Mahdi; Deyhimi, Parviz; Ganjalikhani‐Hakemi, Mazdak; Behfarnia, Parichehr; Shahabuei, M.; Rafiee, Laleh

doi:10.1111/j.1600-0765.2011.01464.x

Cited by 74 publications

(64 citation statements)

References 42 publications

(57 reference statements)

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“…This suggests that IL-21 may be derived from other cell types such as Th17 cells. Recent studies demonstrated the presence of Th17 cytokine in periodontitis tissues (9,54). However, the ability of this T cell subset in producing IL-21 in periodontitis requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, other Th subsets, including regulatory Th cells and Th17 cells, have been demonstrated in periodontal tissues, of which an inverse relationship between these two cell types could be established (8). Whereas Th17 cells promote periodontal inflammation and tissue destruction (9), T regulatory cells are implicated in guard against periodontitis progression (10).…”

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confidence: 99%

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Human Memory B Cells in Healthy Gingiva, Gingivitis, and Periodontitis

Mahanonda

Champaiboon

Subbalekha

et al. 2016

The Journal of Immunology

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The presence of inflammatory infiltrates with B cells, specifically plasma cells, is the hallmark of periodontitis lesions. The composition of these infiltrates in various stages of homeostasis and disease development is not well documented. Human tissue biopsies from sites with gingival health (n = 29), gingivitis (n = 8), and periodontitis (n = 21) as well as gingival tissue after treated periodontitis (n = 6) were obtained and analyzed for their composition of B cell subsets. Ag specificity, Ig secretion, and expression of receptor activator of NF-κB ligand and granzyme B were performed. Although most of the B cell subsets in healthy gingiva and gingivitis tissues were CD19+CD27+CD38− memory B cells, the major B cell component in periodontitis was CD19+CD27+CD38+CD138+HLA-DRlow plasma cells, not plasmablasts. Plasma cell aggregates were observed at the base of the periodontal pocket and scattered throughout the gingiva, especially apically toward the advancing front of the lesion. High expression of CXCL12, a proliferation-inducing ligand, B cell–activating factor, IL-10, IL-6, and IL-21 molecules involved in local B cell responses was detected in both gingivitis and periodontitis tissues. Periodontitis tissue plasma cells mainly secreted IgG specific to periodontal pathogens and also expressed receptor activator of NF-κB ligand, a bone resorption cytokine. Memory B cells resided in the connective tissue subjacent to the junctional epithelium in healthy gingiva. This suggested a role of memory B cells in maintaining periodontal homeostasis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Human Memory B Cells in Healthy Gingiva, Gingivitis, and Periodontitis

Mahanonda

Champaiboon

Subbalekha

et al. 2016

The Journal of Immunology

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“…The increase of Th17 cells in chronic periodontal patients and by Porphyromonas gingivalis exposure to peripheral blood mononuclear cells in vitro were also recognized (13,14).…”

Section: Introductionmentioning

confidence: 99%

Functional Imbalance between Th17, Th1, and Treg Cells in A. actinomyctemcomitans -Accelerated Atherosclerosis

et al. 2013

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Recent studies have shown an association between periodontal disease and cardiovascular disease. We previously reported that Aggregatibacter actinomyctemcomitans（Aa） bacteremia accelerated atherosclerosis in apolipoprotein E-deficient spontaneously hyperlipidemic（Apoe shl ）mice. Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. In this study, we investigated whether the functional imbalance between Th17, Th1, and regulatory T（Treg）cells, existed in Aa-challenged

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“…The main function of IL-17 is to mediate inflammation by stimulating resident cells to secrete potent proinflammatory cytokines like IL-1, IL-6-IL-8 and prostaglandin E2 (PGE2) that exacerbate the inflammatory reaction and tissue destruction. Several studies demonstrated the presence of Th17 cells in chronic periodontitis lesions [37][38][39]. Cytokines produced and induced by Th17 cells like IL-6, IL-23 and IL-1 beta mRNA levels were reported to be elevated in lesions with periodontitis [37].…”

Section: Th17 Cytokinesmentioning

confidence: 99%