Inflammatory Cytokines and the Pathogenesis of Periodontal Disease

Yücel, Özlem Özer

doi:10.4172/1745-7580.1000093

Cited by 2 publications

(2 citation statements)

References 49 publications

(59 reference statements)

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“…T-helper cytokines are essential in periodontal pathogenesis and disease progression. An intense T lymphocyte stage contributes to cellular immune responses by stimulating various CD4 + Th-cell responses [40,41]. Th1 cells activate cellular immunity against intracellular pathogens by proinflammatory cytokines, such as IL-1β, IL-12, IL-2, interferon (IFN)-γ, and TNF-α, associated with periodontal tissue destruction (Figure 2, point 5).…”

Section: Adaptative Responsementioning

confidence: 99%

“…Th2 cells, which produce cytokines like IL-4, IL-10, and IL-11, play a crucial role in humoral immunity and anti-inflammatory properties, attenuating the destructive host response mediated by mostly Th1 and Th17 (Figure 2, point 7) [38,40,41]. T lymphocytes CD8 + regulatory (Treg) cells also play a protective role in alveolar bone homeostasis by suppressing osteoclastogenesis and modulating the innate immune response by attenuating T cells' excessive inflammation and proliferation (Figure 2, point 8) [2].…”

Section: Adaptative Responsementioning

confidence: 99%

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Exploring the Potential of Micro-Immunotherapy in the Treatment of Periodontitis

Ferrà-Cañellas,

Garcia-Sureda

2024

Life

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Periodontitis, characterized by the progressive destruction of dental support tissues due to altered immune responses, poses a significant concern for public health. This condition involves intricate interactions between the immune response and oral microbiome, where innate and adaptive immune responses, with their diverse cell populations and inflammatory mediators, play crucial roles in this immunopathology. Indeed, cytokines, chemokines, growth factors, and immune cells perform key functions in tissue remodeling. Focusing on periodontal therapies, our attention turns to micro-immunotherapy (MI), employing low doses (LDs) and ultra-low doses (ULDs) of immunological signaling molecules like cytokines, growth factors, and hormones. Existing studies across various fields lay the groundwork for the application of MI in periodontitis, highlighting its anti-inflammatory and regenerative potential in soft tissue models based on in vitro research. In summary, this review underscores the versatility and potential of MI in managing periodontal health, urging further investigations to solidify its clinical integration. MI supports an innovative approach by modulating immune responses at low doses to address periodontitis.

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Section: Adaptative Responsementioning

confidence: 99%

Section: Adaptative Responsementioning

confidence: 99%

Exploring the Potential of Micro-Immunotherapy in the Treatment of Periodontitis

Ferrà-Cañellas,

Garcia-Sureda

2024

Life

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Virulence of periodontopathogens Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis: micro-computed tomography and inflammatory cytokine analysis

Wahyukundari¹,

Sari²,

Pujiastuti³

et al. 2018

Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)

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The objective of this study is to determine the difference between A. actinomycetemcomitans and P. gingivalis virulence as the cause of periodontal disease. Thirty male Wistar rats were divided into six groups. Ten rats were induced by 10 ug/mL P. gingivalis lipopolysaccharides (LPS), and the other ten rats were induced by 10 ug/mL crude proteins of A. actinomycetemcomitans. The injection was performed three times for six weeks in the interdental area between the first and the second mandibular right molar by using a 30gauge needle. On the third and seventh days, five rats from each group were decapitated and observed with microcomputed tomography (μ-CT) to determine the severity of alveolar bone resorption. The immunohistochemical method was used to find the expression of macrophage inflammatory cytokines (IL-1β and TNF-α). The ANOVA test was performed to determine the difference among each group. The μ-CT image observation of each group revealed that the severity of alveolar bone resorption was different in each group. In the group that was induced by the crude proteins of A. actinomycetemcomitans, resorption was more advanced than those in the LPS and the control group. A significant increase (p<0.05) was found in IL-1β and TNF-α expressions after induction in both groups on the third and seventh days, with the highest cytokine expression observed on the seventh day. The expressions of IL-1β and TNF-α in the group that was induced by the crude proteins of A. actinomycetemcomitans were significantly higher than those in the LPS group. The crude proteins of A. actinomycetemcomitans showed a greater level of virulence than the P. gingivalis LPS in either alveolar bone resorption or inflammatory cytokine expression.

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Inflammatory Cytokines and the Pathogenesis of Periodontal Disease

Cited by 2 publications

References 49 publications

Exploring the Potential of Micro-Immunotherapy in the Treatment of Periodontitis

Exploring the Potential of Micro-Immunotherapy in the Treatment of Periodontitis

Virulence of periodontopathogens Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis: micro-computed tomography and inflammatory cytokine analysis

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