Significantly upregulated TACSTD2 and Cyclin D1 correlate with poor prognosis of invasive ductal breast cancer

Lin, Hong; Huang, Jianfei; Qiu, Jiliang; Zhang, Huilin; Tang, Xiaojun; Hu, Li; Wang, Changjun; Wang, Zhong-Can; Feng, Zijian; Zhu, Jin

doi:10.1016/j.yexmp.2012.08.004

Cited by 85 publications

(77 citation statements)

References 37 publications

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“…It is important to note that Trop2 is expressed at different levels in different type of breast cancer cells and tissues. Our previous study showed that high expression of Trop2 was only detected in 50% breast cancer patients . In addition, we found that only high concentration of Trop2 Fab exerted significant tumor inhibitory effects.…”

Section: Discussionmentioning

confidence: 99%

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A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo

Lin

Zhang

Wang

et al. 2013

Intl Journal of Cancer

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Human trophoblastic cell surface antigen 2 (Trop2) has been suggested as an oncogene, which is associated with the different types of tumors. In this study, a human Fab antibody against Trop2 extracellular domain was isolated from phage library by phage display technology, and characterized by ELISA, FACS, fluorescence staining and Western blotting analysis. MTT, apoptosis assay and wound healing assay were employed to evaluate the inhibitory effects of Trop2 Fab on breast cancer cell growth in vitro, while tumor‐xenograft model was employed to evaluate the inhibitory effects on breast cancer growth in vivo. The results showed that Trop2 Fab inhibited the proliferation, induced the apoptosis and suspended the migration of MDA‐MB‐231 cells in a dose dependent manner. The expression caspase‐3 was activated, and the expression of Bcl‐2 was reduced while that of Bax was elevated in MDA‐MB‐231 cells by treating with Trop2 Fab. In addition, Trop2 Fab inhibited the growth of breast cancer xenografts and the expression of Bcl‐2 was reduced while that of Bax was elevated in xenografts. Trop2 Fab, which was isolated successfully in this research, is a promising therapeutic agent for the treatment of Trop2 expressing breast cancer.

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Section: Discussionmentioning

confidence: 99%

“…Trop2 has been suggested as an oncogene, which is remarkably associated with the development, progression and metastasis of various types of malignant tumors . Our previous study demonstrated that the high expression of Trop2 was correlated with poor prognosis in breast cancer patients . Thus, Trop2 is an ideal target for targeted therapy of breast cancer.…”

mentioning

confidence: 99%

A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo

Lin

Zhang

Wang

et al. 2013

Intl Journal of Cancer

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“…Up-regulations of LAT1 and 4F2hc that fasten formation of solid tumors were detected in several cancer cell lines including CCA cells [31,32]. Tumor associated calcium signal transducer 2 protein stimulated several human cancer growth and up-regulation of this protein was associated with poor prognosis particularly in invasive cancers [33]. High levels of vault protein expression are correlated with a poor prognosis in certain cancers with some multi-drug resistant (MDR) cancer cell lines [34].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression

Dutta

Reamtong

Panvongsa

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Cholangiocarcinoma (CCA), a common primary malignant tumor of bile duct epithelia, is highly prevalent in Asian countries and unresponsive to chemotherapeutic drugs. Thus, a newly recognized biological entity for early diagnosis and treatment is highly needed. Exosomes are small membrane bound vesicles found in body fluids and released by most cell types including cancer cells. The vesicles contain specific subset of proteins and nucleic acids corresponding to cell types and play essential roles in pathophysiological processes. The present study aimed to assess the protein profiles of CCA-derived exosomes and their potential roles. We have isolated exosomes from CCA cells namely KKU-M213 and KKU-100 derived from Thai patients and their roles were investigated by incubation with normal human cholangiocyte (H69) cells. Exosomes were internalized into H69 cells and had no effects on viability or proliferation of the host cells. Interestingly, the exosomes from KKU-M213 cells only induced migration and invasion of H69 cells. Proteomic analysis of the exosomes from KKU-M213 cells disclosed multiple cancer related proteins that are not present in H69 exosomes. Consistent with the protein profile, treatment with KKU-M213 exosomes induced β-catenin and reduced E-cadherin expressions in H69 cells. Collectively, our results suggest that a direct cell-to-cell transfer of oncogenic proteins via exosomal pathway may be a novel mechanism for CCA progression and metastasis.

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“…Therefore, MAGE-A proteins are generally considered as the tumor-specific antigen (TSA) and ideal target molecule for tumor therapy. Several MAGE-A based immunotherapy and targeted-therapy strategies have been developed and showed positive results (Cameron et al, 2013;Lin et al, 2013a;Straetemans et al, 2012).…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Overexpression of MAGE-A9 predicts unfavorable outcome in breast cancer

Xu¹,

Tang²,

Lu³

et al. 2014

Experimental and Molecular Pathology

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Significantly upregulated TACSTD2 and Cyclin D1 correlate with poor prognosis of invasive ductal breast cancer

Cited by 85 publications

References 37 publications

A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo

A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo

Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression

Overexpression of MAGE-A9 predicts unfavorable outcome in breast cancer

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