Significant worsening sperm parameters are associated to testicular hypotrophy in patients with a high grade varicocele

Güzel, Özer; Aslan, Yılmaz; Balcı, Melih; Tuncel, Altuğ; Ünal, Burcu; Atan, Ali

doi:10.1016/j.acuroe.2015.05.010

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…These results are consistent with previous studies showing that surgically induced varicocoele in rats can hamper spermatogenesis and sperm production [1,31,32]. In men, the impairment of spermatogenesis is proportional to the clinical grade of the varicocoele [33] and also testicular hypotrophy is evident and correlates with spermatogenetic impairment in patients with a high-grade varicocoele [34]. Accordingly, we can argue that the rat varicocoele induced with our surgical procedure is similar to a high-grade clinical varicocoele, probably grade III.…”

Section: Discussionsupporting

confidence: 92%

One‐carbon cycle support rescues sperm damage in experimentally induced varicocoele in rats

et al. 2018

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Section: Discussionsupporting

confidence: 92%

One‐carbon cycle support rescues sperm damage in experimentally induced varicocoele in rats

et al. 2018

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“…In the published literature, most studies regarding the testicular volume‐function focused on the patients with varicocele (Christman, Zderic, & Kolon, ; Guzel et al., ; Khasnavis & Kogan, ; Sorokin et al., ; Woldu, Nees, Van Batavia, Spencer, & Glassberg, ). But to better understand testicular volume‐function relationship, the patients in this study were selected excluding all cases of scrotal disease detected by ultrasound and excluding the clinical factors that significantly affect the testicular function.…”

Section: Discussionmentioning

confidence: 99%

Right testicular volume is a dominant predictor of testicular function determined by sperm parameters and total testosterone

Huang

Liu

et al. 2018

Andrologia

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This study aims to evaluate the predictive value of left testicular volume (LTV) and right testicular volume (RTV) for testicular function respectively. Men who requested fertility testing for any reason were enrolled from December 2012 to November 2015. Subjects with primary scrotal diseases or a condition interfering reproductive system were excluded. Testicular volume (TV) was evaluated by scrotal ultrasound. Sex hormone and semen analysis including sperm concentration (SC) and sperm motility rate (SMR) were performed. Statistical analysis including comparison, stepwise linear regression and logistic regression was used. Two hundred and seventy-four patients with oligoasthenozoospermia/low testosterone and 27 control subjects were enrolled. Both LTV and RTV positively correlated with testicular function, and no differences were found between bilateral TV. RTV is the best independent factor associated with testicular function determined by SC (β=.292, p < .001), SMR (β=.227, p < .001) and total testosterone (TT) (β=.245, p < .001). Using a RTV value of 15.47 ml, the highest discriminating sensitivity and specificity were 66.7% and 62.4% respectively. RTV (<15 ml) was the only positive predictor for low testicular function (odds ratio=2.79, 95% confidence interval: 1.18-6.66; p =.020). RTV rather than LTV is the independent factor of overall testicular function determined by semen quality and TT levels. Further studies are needed to support and elucidate the difference in volume-function between bilateral testes.

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“…Boys aged between 12 and 17 years with hypotrophic left testis had pathologically low semen parameters (Guzel et al, ).…”

Section: Introductionmentioning

confidence: 99%

Early varicocelectomy by percutaneous scleroembolization improves seminiferous tubules spermatozoa release in the adolescent phase of testicular growth

et al. 2019

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Varicocele is a rather common andrological condition in adolescents, which can adversely affect testicular growth and seminal parameters, leading to infertility in about 20% of adults. The aim of this study was to investigate if treating varicocele before the age of 18 is a beneficial option to improve testicular hypotrophy and seminal parameters and if minimally invasive techniques could be an appropriate treatment choice for adolescent varicocele associated with spermatic vein reflux. A percutaneous scleroembolization was performed in sixty-four consecutive young patients (13-19 years old) with left varicocele, preceded by a fluoroscopy. In thirty-four of them,

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Significant worsening sperm parameters are associated to testicular hypotrophy in patients with a high grade varicocele

Cited by 7 publications

References 13 publications

One‐carbon cycle support rescues sperm damage in experimentally induced varicocoele in rats

One‐carbon cycle support rescues sperm damage in experimentally induced varicocoele in rats

Right testicular volume is a dominant predictor of testicular function determined by sperm parameters and total testosterone

Early varicocelectomy by percutaneous scleroembolization improves seminiferous tubules spermatozoa release in the adolescent phase of testicular growth

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