This meta-analysis of prospective cohort studies demonstrates that obesity negatively influences the overall complication rate, dislocation rate, functional outcome and operative time of primary total hip arthroplasty.
Optically addressable
spin defects in wide-band-gap semiconductors
as promising systems for quantum information and sensing applications
have recently attracted increased attention. Spin defects in two-dimensional
materials are expected to show superiority in quantum sensing due
to their atomic thickness. Here, we demonstrate that an ensemble of
negatively charged boron vacancies (VB
–) with good spin properties in hexagonal
boron nitride (hBN) can be generated by ion implantation. We carry
out optically detected magnetic resonance measurements at room temperature
to characterize the spin properties of ensembles of VB
– defects,
showing a zero-field splitting frequency of ∼3.47 GHz. We compare
the photoluminescence intensity and spin properties of VB
– defects
generated using different implantation parameters, such as fluence,
energy, and ion species. With the use of the proper parameters, we
can successfully create VB
– defects with a high probability. Our
results provide a simple and practicable method to create spin defects
in hBN, which is of great significance for realizing integrated hBN-based
devices.
Endothelial cells are thought to play a key role in sepsis pathogenesis: vascular endothelial damage occurs in severe sepsis and multiple organ dysfunction. Soluble vascular endothelial cadherin (VE-cadherin) levels were investigated in a prospective study involving 28 consecutive critically ill patients with or without severe sepsis who were admitted to surgical intensive care; 13 healthy age-matched volunteers were included as controls. Soluble VE-cadherin levels increased significantly in patients with severe sepsis compared with ill patients without severe sepsis and healthy controls. There was a significant linear correlation between soluble VE-cadherin levels and illness severity scores. Soluble VE-cadherin levels were significantly higher in patients who died compared with survivors. In vitro cell culture showed that serum from patients with severe sepsis greatly decreased VE-cadherin staining at intercellular junctions and total VE-cadherin expression in human umbilical cord vein endothelial cells. These findings suggest that endothelial cells play an important role in the poor outcome of patients with severe sepsis.
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