Significant of Serum 25-Hydroxyvitamin D and Thyroid Hormones Levels in Pregnant Women in Jordan

Correlation of Serum 25-Hydroxyvitamin D and Thyroid Hormones in Pregnant Women in Amman-Jordan

“…The significant correlation between high vitamin D and low TSH (p< 0.005) in pregnant women with a sufficient level of vitamin D (> 30 ng/ml) revealed in our study which agrees with other study [2]. Meanwhile no significant statistical variation was found (p<0.01) between vitamin D level and FT4 which agree with other studies [2,9,11] adding to that correlation between vitamin D and FT3 (p< 0.01) was not clear suggesting further work is needed [9,11] including larger study sample of pregnant women divided according to weeks of pregnancy, age and those wearing Heijab [44]. Meanwhile if the responsible factors for vitamin D deficiency could not be revealed so that the correct concentration of vitamin D could maintain in pregnant women public health awareness should be reused and recommendation for vitamin D supplementation before and after pregnancy is extremely important.…”

“…Results in our study revealed 49.0% prevalence of 25 hydroxyvitamin D insufficiency in pregnant subjects who lived mainly in sunny zone which agree with other study [2] indicating that high levels of sunshine in Jordan might not necessarily compensate for vitamin D deficiency. Therefore, other factors should be investigated to understand the cause of vitamin D depletion during pregnancy so the right vitamin D concentration could be achieve .Heijab might have negative effect on vitamin D cutaneous synthesis [44]. Many studies have shown significant relationship between serum 25-Hydroxyvitamin D and thyroid hormones during pregnancy due to the role of vitamin D in the function of cardiac, skeletal muscles, immune cell proliferation and differentiation [2].…”

“…Many studies have shown significant relationship between serum 25-Hydroxyvitamin D and thyroid hormones during pregnancy due to the role of vitamin D in the function of cardiac, skeletal muscles, immune cell proliferation and differentiation [2]. As mentioned previously 25(OH) D status is Influenced by many factors [2,11,44] one of these factor is thyroid hormones changes by fetus action causing depletion of TSH, FT4 and FT3 leading to various problems such as placental abruption, miscarriage, fetal growth retardation [49]. Other studies recommended vitamin D supplementation during pregnancy [8,12,25].…”