Correlation of Serum 25-Hydroxyvitamin D and Thyroid Hormones in Pregnant Women in Amman-Jordan

Nizar, Battikhi Mohammed

doi:10.15406/jmen.2017.04.00099

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…Both vitamin D and thyroid hormone bind to steroid hormone receptors, which are identical to one another 20 . A study found no link between vitamin D, FT4, or FT3 during pregnancy, however there was a significant link between vitamin D and decreased TSH in pregnant women with appropriate vitamin D levels (greater than 30 ng/ml) 13 . Despite vitamin D shortage among these women, no link was established between 25hydroxy vitamin D and thyroid function in a pregnancy research 14 .…”

Section: Discussionmentioning

confidence: 97%

“…In the present study, the TSH levels are not dependent on the vitamin D supplementation and when compared with age and BMI, the TSH levels are not statistically significant after the vitamin D supplementation and these findings are in line with the previous studies. 13,14 table 3. Due to its activity in the thyroid gland and even in patients with thyroid disorders and thyroid autoantibody, several types of research have shown that vitamin D has an effect on thyroid hormone.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Vitamin – D Supplementation On Serum TSH Levels in Pregnant Women and Its Co Relation to Age and Body Mass Index.

Srilekha

Vijayalakshmi

Indla

2022

Int J Life Sci Pharm Res

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The main aim of the study is to investigate the association between vitamin D after insufficiency and thyroid hormone levels in pregnancy. The objective of the present study is to see how serum vitamin D levels are related to Thyroid stimulating hormone (TSH) during the first trimester of after pregnancy in relation to the age and BMI of the pregnant women. In this crosssectional study 100 pregnant women (50as control group, 50 as vitamin D supplementation group) are included and categorized as per their age and BMI. Vitamin D supplementation is done under the supervision of the gynecologist at the start of 1st trimester and at the end of the first-trimester, serum TSH levels are estimated in them. The mean was analysed by two-way ANOVA (Twoway analysis of variance with Bonferroni‘t’ test method). For all the statistics and graph plotting, SigmaPlot 13.0 (Systat software, USA) was used. P <0.05 is considered significant. The difference in the mean values among the different levels of the group is not significant enough to exclude the after possibility that the difference is just due to random sampling variability after allowing for the effects of differences in BMI Category. There is not a statistically significant difference (P = 0.506). According to the findings of this study, there is no correlation between vitamin D levels and TSH levels in relation to the age and BMI of pregnant women; therefore, more research should be done on groups of pregnant women divided by weeks of pregnancy and age, and vitamin D supplementation should be recommended.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin – D Supplementation On Serum TSH Levels in Pregnant Women and Its Co Relation to Age and Body Mass Index.

Srilekha

Vijayalakshmi

Indla

2022

Int J Life Sci Pharm Res

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Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study

Ahi

Adelpour

Fereydooni

et al. 2022

International Journal of Endocrinology

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Background. The aim of this study was to evaluate the prevalence of vitamin D deficiency in pregnant women to investigate the relationship between vitamin D level and thyroid function. Methods. In this cross-sectional descriptive study, a total number of 66 patients during the three trimesters of pregnancy were investigated; 22 pregnant women were studied in each trimester of pregnancy. We evaluated thyroid function tests and thyroid autoantibodies (TPOAb and TGAb), as well as the serum level of 25OHD, to determine the relationship between vitamin D level and autoimmune or non-autoimmune thyroid disease in pregnancy. Results. Pearson’s correlation in all subjects showed that vitamin D levels did not have a significant relationship with maternal age. Only in the third trimester, there was a significant difference in maternal age based on their vitamin D status. There was no significant difference between the trimesters of pregnancy and vitamin D status ( P > 0.05 ). Also, there were no significant differences between serum levels of vitamin D within three trimesters. Examination of thyroid function tests during pregnancy in relation to vitamin D showed that there was no significant Spearman’s correlation between thyroid function status and serum vitamin D level ( P > 0.05 ). There was no significant difference in the mean level of serum 25OH vitamin D in each subgroup of thyroid status ( P > 0.05 ). Regarding the pregnancy outcomes, two newborns were admitted to NICU, meconium aspiration was in one case, and IUFD in another case led to pregnancy termination. These four cases were related to the maternal history of hypothyroidism. Conclusion. There was no significant relationship between vitamin D and pregnancy trimester. The serum level of vitamin D had no particular effect on the outcome of pregnancy and the thyroid gland function.

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Associations between Dynamic Vitamin D Level and Thyroid Function during Pregnancy

Wang

Jiao

et al. 2022

Nutrients

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Optimal Vitamin D (VitD) status and thyroid function are essential for pregnant women. This study aimed to explore associations between dynamic VitD status and thyroid function parameters in each trimester and throughout the pregnancy period. Information on all 8828 eligible participants was extracted from the Peking University Retrospective Birth Cohort in Tongzhou. Dynamic VitD status was represented as a combination of deficiency/sufficiency in the first and second trimesters. Thyroid function was assessed in three trimesters. The associations between VitD and thyroid function were assessed by multiple linear regression and generalized estimating equation models in each trimester and throughout the pregnancy period, respectively. The results indicated that both free thyroxine (fT4; β = 0.004; 95%CI: 0.003, 0.006; p < 0.001) and free triiodothyronine (fT3; β = 0.009; 95%CI: 0.004, 0.015; p = 0.001) had positive associations with VitD status in the first trimester. A VitD status that was sufficient in the first trimester and deficient in the second trimester had a lower TSH (β = −0.370; 95%CI: −0.710, −0.031; p = 0.033) compared with the group with sufficient VitD for both first and second trimesters. In conclusion, the associations between VitD and thyroid parameters existed throughout the pregnancy. Maintaining an adequate concentration of VitD is critical to support optimal thyroid function during pregnancy.

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Correlation of Serum 25-Hydroxyvitamin D and Thyroid Hormones in Pregnant Women in Amman-Jordan

Cited by 3 publications

References 42 publications

Effect of Vitamin – D Supplementation On Serum TSH Levels in Pregnant Women and Its Co Relation to Age and Body Mass Index.

Effect of Vitamin – D Supplementation On Serum TSH Levels in Pregnant Women and Its Co Relation to Age and Body Mass Index.

Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study

Associations between Dynamic Vitamin D Level and Thyroid Function during Pregnancy

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