Significant loss of bone mass in patients with early, active ankylosing spondylitis: A followup study

Gratacós, Jordi; Collado, Antonio; Pons, Françesca; Osaba, MJ Martinez de; Sanmartí, Raimón; Roqué, Mercè; Larrosa, M.; Múñoz-Gómez, J

doi:10.1002/1529-0131(199911)42:11<2319::aid-anr9>3.0.co;2-g

Cited by 163 publications

(71 citation statements)

References 18 publications

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“…Similar to these findings, bone resorption markers have been found to be increased in AS, especially in patients with active disease (23,24), which most likely is a reflection of trabecular bone loss as the basis of osteoporosis and increased fracture risk in AS. MRI has been very helpful in clarifying the pathologic events in AS (4,(25)(26)(27).…”

Section: Transformation From Acute Inflammation To New Bone Formationsupporting

confidence: 68%

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

Sieper¹,

Appel²,

Braun³

et al. 2008

Arthritis & Rheumatism

204

107

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Section: Transformation From Acute Inflammation To New Bone Formationsupporting

confidence: 68%

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

Sieper¹,

Appel²,

Braun³

et al. 2008

Arthritis & Rheumatism

204

107

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“…Even the patients with no movement restriction in the early stage of the disease might experience bone loss caused by inflammatory activity (22,23). In our study, BMD values of the patients in the PsA group were lower than controls; however, there was no significant relation between disease duration and BMD values.…”

Section: Discussioncontrasting

confidence: 60%

Relation Between Osteoporosis and Vitamin D Levels and Disease Activity in Psoriatic Arthritis

Oten¹,

Başkan²,

Sivas³

et al. 2017

Erciyes Med J

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Objective: This study investigated the relation between osteoporosis and vitamin D levels and the disease activity in patients with psoriatic arthritis (PsA). Materials and methods:In this study, 58 patients with PsA and 58 healthy controls were included. Bone mineral density (BMD) measurements of patients and controls were performed using dual-energy X-ray absorptiometry. Complete blood count, serum 25(OH)D3, parathormone, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), total calcium, ionized calcium, and phosphorous levels of all participants were measured. Disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Disease Activity Index for Reactive Arthritis (DAREA), and the Disease Activity Score 28 (DAS28). The functional status was evaluated using the Health Assessment Questionnaire for the spondyloarthropathies (HAQ-S), and enthesopathy was evaluated using the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES).Results: BMD values of the patients were significantly lower than those of the controls. There was a negative but statistically insignificant relationship between the lateral lumbar BMD values of the patients and clinical activity signs. Vitamin D levels of the patients were significantly lower than those of the controls. Although there was no correlation between vitamin D levels and ESR and CRP levels, a negative but statistically insignificant relation was found between vitamin D levels and BASDAI, DAREA, and DAS28. The level of CRP, BASDAI, MASES, DAREA, HAQ-S, and DAS28 scores were higher in the patients with osteoporosis; however, none of the differences were statistically significant. Conclusion:In this study, the incidence of osteoporosis was higher and vitamin D levels were lower in patients than in controls.

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“…A previous study of 23 patients with AS demonstrated elevated levels of CPII and 846 epitope in patients with concomitant peripheral synovitis, which supports this hypothesis (23). However, increased osteoclast activation has been documented in animal models of AS (35) and bone resorption markers are increased in AS, particularly in patients with active disease (36,37).…”

Section: Discussionmentioning

confidence: 64%

Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis

Maksymowych¹,

Landewé²,

Conner‐Spady³

et al. 2007

Arthritis & Rheumatism

153

100

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Objective. In prospective studies, only baseline radiographic damage has been identified as an independent predictor of radiographic progression in ankylosing spondylitis (AS). Several biomarkers have been identified as independent predictors of radiographic progression in rheumatoid arthritis, however, and these may be of use in AS. This study was undertaken to analyze serologic biomarkers as predictors of radiographic progression in AS.Methods. We measured a panel of biomarkers reflecting cartilage turnover and osteoclasis. These biomarkers were cartilage oligomeric matrix protein, human cartilage gp-39 (YKL-40), type II collagen epitopes detected by the C2C and C1,2C degradation assays and the CPII synthesis assay, aggrecan 846 epitope, osteoprotegerin, and matrix metalloproteinase 3 (MMP-3). The analysis was performed in a cohort of AS patients from the Netherlands, Belgium, and France enrolled in a longitudinal study, the Outcome Assessments in Ankylosing Spondylitis International Study. We examined 2-year radiographic progression data scored using the modified Stoke AS Spine Score (mSASSS).Results. Complete data were available on 97 patients. Only the biomarkers YKL-40 and MMP-3 showed weak to moderate univariate correlation with 2-year progression. After adjustment for sex, age, disease duration, C-reactive protein level, and baseline mSASSS, only MMP-3 was significantly associated with 2-year progression (␤ ‫؍‬ 0.29, P ‫؍‬ 0.004). Logistic regression analysis revealed MMP-3 (cutoff 68 ng/ml; odds ratio 9.4 [95% confidence interval 1.6-56]) and baseline mSASSS (cutoff 10 mSASSS units; odds ratio 18.6 [95% confidence interval 2.5-138]) as the only independent predictors of 2-year progression (cutoff 3 mSASSS units; model R 2 ‫؍‬ 50%). MMP-3 was primarily contributory in patients who already had substantial baseline damage (>10 mSASSS units).Conclusion. These results indicate that MMP-3 is a significant independent predictor of radiographic progression in patients with AS, particularly in those with preexisting radiographic damage.Ankylosing spondylitis (AS) is characterized by the presence of inflammation in the spine and the development of ankylosis in the facet joints and intervertebral discs, which leads to immobility and functional impairment. The degree and rate of progression of radiographic changes can be reliably assessed using a validated scoring method, the modified Stoke AS Spine Score (mSASSS), which records structural changes in

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Significant loss of bone mass in patients with early, active ankylosing spondylitis: A followup study

Cited by 163 publications

References 18 publications

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

Relation Between Osteoporosis and Vitamin D Levels and Disease Activity in Psoriatic Arthritis

Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis

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