Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men

Abstract

ABSTRACT. Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution of rs4420638 to the risk of CHD in Han Chinese. In addition, we performed a meta-analysis to evaluate the association between rs4420638 and CHD in Europeans and Asians. The results show that rs4420638 is significantly correlated with increased CHD risk in male Han Chinese [P = 0.040, odds ratio (OR) = 1.34, 95% confidential interval (95%CI) = 1.01-1.78] and is likely to increase the risk of CHD under the dominant model in males (P = 13415 rs4420638 and CHD in Han Chinese men ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13414-13424 (2015) 0.036, OR = 1.38, 95%CI = 1.02-1.88). A further subgroup analysis by rs4420638 genotype found a significant association of rs4420638 AA with high-density lipoprotein cholesterol (HDL-C) (P = 0.012) and APOA-I levels (P = 0.0001) in males. The meta-analysis suggests that rs4420638 significantly increases the risk of CHD (OR = 1.18, 95%CI = 1.14-1.22, P < 0.0001, fixed-effect method). Our case-control study shows that rs4420638 genotype AA has a significant association with the concentrations of circulating HDL-C and APOA-I in CHD in Han Chinese males. The meta-analysis suggests that rs4420638 is associated with CHD risk in Europeans and Asians.

Associations of Genetic Variations in ABCA1 and Lifestyle Factors with Coronary Artery Disease in a Southern Chinese Population with Dyslipidemia: A Nested Case-Control Study

“…Coronary artery disease is a complex disease that is affected by genetic and environmental factors. Most genes can affect lipid metabolism in the body, followed by the development of atherosclerosis [10,11,12,13,14,15,16]. Some studies have found that cardiovascular diseases such as coronary heart disease have a strong genetic basis, demonstrated by family associations and degrees of genetic influence as high as 40–50% [17,18].…”

Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease

“…Gender disparity has been found in APOE-related cardiovascular disease (27). In the previous studies, we have shown that CHD risk was gender-dependent in the Han Chinese and that APOE rs4420638 polymorphism was significantly associated with increased CHD risk in male Han Chinese (28). This observation might be explained by the differences of hormonal profiles, smoking status, alcohol-drinking, occupation, and dietary habits between males and females (29,30).…”

Prediction of cholesterol ratios within a Korean population

“…The rs4420638 which is located in the APOE-APOC1-APOC4-APOC2 cluster showed a protective effect on LDL-cholesterol levels [ 28 ]. The rs4420638 was also responsible for risk of coronary heart disease of Asian population [ 29 ]. The association of LPL with lipid variables and coronary artery disease has been reported many times [ 30 – 32 ].…”