Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease

Wu, Nan

doi:10.14744/anatoljcardiol.2018.23682

Cited by 9 publications

(13 citation statements)

References 39 publications

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“…Similarly, a case study reported a significant association of APOE rs7259620 with CHD risk in men, instead of in women. 39 Another study has shown that CDKN2BAS rs7865618 is a risk factor for CHD in women. 40 In addition, CYP11B1 rs6410 and rs5283 are significantly associated with an increased risk of CHD in women, but not in men.…”

Section: Discussionmentioning

confidence: 99%

Association of the L3MBTL3 rs1125970 and rs4897367 gene polymorphisms with coronary heart disease susceptibility in the Chinese population: a case-control study

Li,

Zhang,

et al. 2023

Journal of Cardiovascular Pharmacology

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Coronary heart disease (CHD) is a prevalent heart disease with the high incidence and mortality rates worldwide, and its pathogenesis is related to genetic factors. L3MBTL3 has been reported to be potentially linked to CHD susceptibility. This study aims to explore the correlation between L3MBTL3 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese population. Three SNPs (rs1125970 A/T, rs4897367 T/C, and rs2068957 A/G) in L3MBTL3 from 649 patients with CHD and 649 healthy controls were genotyped using the Agena MassARRAY platform. The relationship between SNPs and CHD risk was evaluated by logistic regression analysis. Our study indicated that rs1125970 (TT: OR = 0.76, p = 0.014) and rs4897367 (TT: OR = 0.74, p = 0.021) were related to a decreased susceptibility to CHD. Stratified analyses showed that rs1125970 could reduce the risk of CHD in males, subjects aged< 60 years, with a BMI< 24 kg/m2, and non-hypertensive patients. Rs4897367 exerted a risk-decreasing influence on CHD in non-diabetic patients. In the haplotype analysis, individuals with the Trs4897367Ars2068957 haplotype were less likely to develop CHD (OR = 0.74, p = 0.024). In summary, L3MBTL3 rs1125970 and rs4897367 were significantly correlated with a decreased susceptibility to CHD in the Chinese population.

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Section: Discussionmentioning

confidence: 99%

Association of the L3MBTL3 rs1125970 and rs4897367 gene polymorphisms with coronary heart disease susceptibility in the Chinese population: a case-control study

Li,

Zhang,

et al. 2023

Journal of Cardiovascular Pharmacology

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“…The SNPs were APOE rs7259620, PVRL2 rs403155, TOMM40 rs157581, EXOC3L2 rs10406604, and CD3EAP rs3212986. In Han Chinese (784 with cardiovascular diseases and 730 without cardiovascular diseases) APOE rs7259620 had a positive association with cardiovascular diseases only in men, not women without adjusting for the covariates [ 28 ]. The study explained that the association may be due to gender differences in hormonal profiles, smoking status, alcohol-drinking, occupation, and dietary habits.…”

Section: Discussionmentioning

confidence: 99%

A minor allele of the haplotype located in the 19q13 loci is associated with a decreased risk of hyper-LDL-cholesterolemia, and a balanced diet and high protein intake can reduce the risk

Park

Kang

2020

Lipids Health Dis

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Background Although the human chromosome 19q13 loci are reported to be associated with hyper-LDL-cholesterolemia, the haplotype of single nucleotide polymorphism (SNP) has not been studied. Therefore, the association of the haplotype in 19q13 loci with hyper-LDL-cholesterolemia was determined and their interactions with lifestyles and nutrient intakes were evaluated in 28,445 Koreans aged > 40 years. Methods SNPs were selected from 19q13 loci that had an association with hyper-LDL-cholesterolemia with the adjustment of confounders (age, gender, area of residence, and body mass index). Haplotype was constructed from the selected SNPs. An adjusted odds ratio of the haplotype for hyper-LDL-cholesterolemia and the interaction between haplotype and lifestyles was analyzed after adjusting for covariates. Results Hyper-LDL-cholesterolemia had an association with apolipoprotein E ( APOE) _ rs7259620, translocase of outer mitochondrial membrane 40( TOMM40) _rs157581, poliovirus receptor-related 2( PVRL2) _rs403155, exocyst complex component 3-like 2( EXOC3L2) _ rs10406604 and CD3e molecule-associated protein ( CD3EAP) _rs3212986 in 19q13. The haplotype of these SNPs had a negative association with hyper-total-cholesterolemia and hyper-LDL-cholesterolemia by 0.669 and 0.684 times, respectively, after adjusting for covariates. The incidence of cardiovascular diseases, especially myocardial infarction, had a negative association with the minor alleles. The balanced diet pattern (BD) and protein intake had a significant interaction with the haplotype: the major-allele of the haplotype exhibited a positive association with hyper-LDL-cholesterolemia, compared to the minor allele, only when combined with a high intake of BD. The participants with the minor allele exhibited a lower hyper-LDL-cholesterolemia risk compared to those with the major allele only with high protein intake. Conclusion The minor allele of haplotype located in 19q13 loci protected against hyper-LDL-cholesterolemia, especially with BD and high protein intake. The minor allele also had a negative association with myocardial infarction events.

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“…[41] Stx-1A maps in a region 70kb close to one of the genes suggested by GWAS: that is MLX-interacting protein-like (MLXIPL), significantly associated with Coronary heart disease. [42] An in-depth evaluation of the Stx-1A SNPs influence in cardiologic risk is warranted to confirm the involvement of these SNPs in IHD.…”

Section: Discussionmentioning

confidence: 99%

The Syntaxin-1A gene single nucleotide polymorphism rs4717806 associates with the risk of ischemic heart disease

et al. 2019

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Ischemic heart disease (IHD) has a genetic predisposition and a number of cardiovascular risk factors are known to be affected by genetic factors. Development of metabolic syndrome and insulin resistance, strongly influenced by lifestyle and environmental factors, frequently occur in subjects with a genetic susceptibility. The definition of genetic factors influencing disease susceptibility would allow to identify individuals at higher risk and thus needing to be closely monitored. To this end, we focused on a complex of soluble-N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), playing an important role in metabolic syndrome and insulin resistance, involved in endothelial dysfunction and heart disease. We assessed if genetic variants of the SNARE genes are associated with IHD. SNAP25 rs363050 , Stx-1A rs4717806 , rs2293489 , and VAMP2 26bp ins/del genetic polymorphisms were analyzed in a cohort of 100 participants who underwent heart surgery; 56 of them were affected by IHD, while 44 were not. A statistical association of plasma glycemia and insulin resistance, calculated as Triglyceride glucose (TyG) index, was observed in IHD ( P < .001 and P = .03, respectively) after binomial logistic stepwise regression analysis, adjusted by age, gender, diabetes positivity, waist circumference, and cholesterol plasma level. Among genetic polymorphisms, rs4717806(A) and rs2293489(T) , as well as the rs4717806 – rs2293489 (A-T) haplotype were associated with higher risk for IHD ( Pc = .02; Pc = .02; P = .04, respectively). Finally, a statistical association of rs4717806(AA) genotype with higher TyG index in IHD patients ( P = .03) was highlighted by multiple regression analysis considering log-transformed biochemical parameters as dependent variable and presence of coronary artery disease, age, gender, waist circumference, presence of diabetes as predictors. These results point to a role of the Stx-1A rs4717806 SNP in IHD, possibly due to its influence on Stx-1A expression and, as a consequence, on insulin secretion and glucose metabolism.

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Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease

Cited by 9 publications

References 39 publications

Association of the L3MBTL3 rs1125970 and rs4897367 gene polymorphisms with coronary heart disease susceptibility in the Chinese population: a case-control study

Association of the L3MBTL3 rs1125970 and rs4897367 gene polymorphisms with coronary heart disease susceptibility in the Chinese population: a case-control study

A minor allele of the haplotype located in the 19q13 loci is associated with a decreased risk of hyper-LDL-cholesterolemia, and a balanced diet and high protein intake can reduce the risk

The Syntaxin-1A gene single nucleotide polymorphism rs4717806 associates with the risk of ischemic heart disease

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