Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis

Guo, Chong; Wen, Li; Song, Jukun; Zeng, Weng-Jing; Dan, Chao; Niu, Yu‐Ming; Shen, Ming

doi:10.18632/oncotarget.24193

Cited by 18 publications

(12 citation statements)

References 54 publications

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“…Cervical cancer associated with a polymorphism at this time is not conclusive: −1082 polymorphism was suggested as a marker of genetic susceptibility to cervical cancer among Japanese women but was not significantly increased in Zimbabwean women or Korean women [88]. In a meta-analysis, including 17 publications of Asian, African, and Caucasian populations, it did not find a significant association between the polymorphism and cervical cancer risk [89]. Other meta-analysis looking for association between −1082 G/A polymorphism and cervical cancer risk, including the same population, report as well that there is no association [90].…”

Section: Diseasementioning

confidence: 81%

IL10 as Cancer Biomarker

González‐Garza¹,

Cruz-Vega²,

Maldonado‐Bernal³

2021

Translational Research in Cancer

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Chronic inflammation can trigger events that would induce the malignant transformation of cells and carcinogenesis. Cytokines play a crucial role and can control the development and multiplication of cancerous cells. However, clinical data present controversy about the participation of these proteins in the establishment and development of cancer. Interleukin 10 (IL-10), a potent anti-inflammatory cytokine, has been the subject of multiple studies. Several studies have reported that IL-10 has pro-and antitumor effects. Elevated levels of IL-10 are associated with increased tumor growth with poor prognosis and drug resistance. However, this cytokine has both tumor-promoting and tumor-inhibiting properties. In vitro and in vivo studies report mechanisms by which IL-10 expression downregulates class I, which results in the control of the metastatic disease. IL-10 also inhibits tumorigenesis via downregulation of other cytokines. The variation observed could be the result of concentration ranges of this protein, genetic polymorphism, or both. The value obtained may serve as a biomarker indicative of tumor development and its prognosis.

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Section: Diseasementioning

confidence: 81%

IL10 as Cancer Biomarker

González‐Garza¹,

Cruz-Vega²,

Maldonado‐Bernal³

2021

Translational Research in Cancer

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“…Генетические вариации генов, кодирующие провоспалительные белки, противовоспалительные цитокины и хемокины, могут приводить к изменениям в функции или количестве ассоциированных цитокинов и поэтому считаются определяющими факторами против ВПЧ и противоопухолевого иммунитета [15]. Также известно о полиморфизме генов IL-6, которые ассоциируются с риском развития РШМ [16].…”

Section: результаты и обсуждение / Results and Discussionunclassified

“…IL-10 обладает как иммунодепрессивным, так и антиангиогенным эффектом и поэтому может оказывать как опухолевое, так и противоопухолевое действие [36][37][38]. Исследования однонуклеотидного полиморфизма (-1082 GA -819, -592 гена IL-10) показали детерминированную ассоциацию с РШМ [39].…”

Section: противовоспалительные цитокины / Anti-inflammatory Cytokinesunclassified

Genetic predisposition for cervical cancer

Rotaru

Lapochikina

2020

Akušerstvo, ginekologiâ i reprodukciâ

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Aim: to examine the role of genetic factors and the human papillomavirus (HPV) in the development of cervical neoplasia based on current literature data on viral carcinogenesis.Materials and methods. A systematic review of the literature about genetic predisposition to cervical cancer (CC) based on electronic data was performed: the search was carried out in International Scientific Databases (MNBD) PubMed/MEDLINE, and manual search was also carried out in the lists of primary sources. Only full-text publications were selected.Results and discussion. CC is a multifactorial disease assumed to have a genetic predisposition component of the host and is caused by a persistent HPV-infection of high oncogenic risk. The immune system plays a major role in HPV infection. Modifications in cellular immune response mechanisms are responsible for the failure to eliminate HPV. On the other hand, immune tolerance promotes viral persistence and cancer progression. The main genes involved in the development of CC are oncogenes, tumor suppressor genes (Rb and TP53), cytokines (IL, IFNG), chemokines (CXCL), genes involved in antigen processing, as well as the contribution of each polymorphism or even haplotypes play a role in cervical carcinogenesis.Conclusion. Research results demonstrate the role of genetic polymorphisms of cytokines, chemokines, receptors, genes involved in antigen processing, and tumor suppressors genes in chronization of HPV-infection.

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“…Previous studies had demonstrated that these three polymorphisms were proposed to affect the transcription efficiency and expression of the IL-10 gene [41]. More than 70% of the individual variability in human IL-10 production has been attributed to genetic variation, which could help to predict patient susceptibility to the disease as well as the severity and progression of the disease [42][43][44]. For the -1082A>G polymorphism, the A allele demonstrated a higher binding affinity to the transcription factor PU.1, resulting in decreased transcriptional activity and lower expression level of IL-10 [45].…”

Section: Journal Of Immunology Researchmentioning

confidence: 99%

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Huang

et al. 2020

Journal of Immunology Research

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Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD susceptibility. Online databases (PubMed, Embase, Science Citation Index (SCI), CNKI, and WanFang) were searched to identify eligible studies. Odds ratio (OR) and a 95% confidence interval (CI) were applied to assess the relationship strength between IL-10 -1082A>G (rs1800896), -819T>C (rs1800871), and -592A>C (rs1800872) polymorphisms and BD susceptibility. Publication bias, sensitivity, and cumulative analyses were conducted to measure the robustness of our findings. Finally, fifteen articles (36 independent case-control studies) involving 5,971 patients and 8,913 controls were included. Overall, significant associations between -819T>C polymorphisms and BD risk were observed in the total population (C vs. T: OR=0.72, 95%CI=0.67‐0.77, P<0.01, I2=36.6%; TC vs. TT: OR=0.73, 95%CI=0.66‐0.80, P<0.01, I2=23.0%; CC vs. TT: OR=0.52, 95%CI=0.39‐0.70, P<0.01, I2=53.7%; TC+CC vs. TT: OR=0.67, 95%CI=0.61‐0.71, P<0.01, I2=22.1%; and CC vs. TT+TC: OR=0.66, 95%CI=0.53‐0.82, P<0.01, I2=57.8%). Moreover, the IL-10 -592 A>C polymorphism and the ACC haplotype exhibited a significant, protective effect against BD susceptibility. In summary, our meta-analysis suggested that IL-10 gene polymorphisms may play a salient role for BD development.

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Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis

Cited by 18 publications

References 54 publications

IL10 as Cancer Biomarker

IL10 as Cancer Biomarker

Genetic predisposition for cervical cancer

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

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