Significant association between <i>RETN</i> genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head

Liu, Chang; An, Feimeng; Cao, Yong; Wang, Jiaqi; Wu, Huiqiang; Wang, Jianzhong

doi:10.1002/mgg3.822

Cited by 5 publications

(3 citation statements)

References 22 publications

(25 reference statements)

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“…Motomura et al [12] found that plasma TG level and LDL increase were associated with increased risk of steroidinduced ONFH. Our previous study on alcohol-induced ONFH found that TC / HDL was statistically signi cant compared with the control group [18]. Our study found that decreased TC levels and increased LDL levels increased the risk of avascular ONFH.…”

Section: Discussionsupporting

confidence: 42%

Index Analysis of Osteonecrosis and Related Causes

Cao

et al. 2020

Preprint

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Background: The pathogenesis of non-traumatic osteonecrosis of the femoral head (ONFH ) is related to the interruption of blood supply caused by lipid metabolism and hypercoagulability. The purpose of this study was to explore the relationship between clinical biochemical parameters and non-traumatic ONFH. Methods: The basic information and biochemical indexes of 1292 patients with non- traumatic ONFH and 1880 healthy controls were collected. SPSS software (version 22.0) was used to process and analyze the data. T-test was used for quantitative analysis. Chi-square test was used for categorical variables.p< 0.05 were the index with statistical significance. Results: In the population sample, TC (p= 0.00004), LDL (p= 0.014) and PLT (p= 0.000005) levels were statistically significant between the two groups.In men, levels of TC (p = 0.004), LDL (p= 0.011), and PLT (p= 0.00005) were statistically significant between the two groups.In women, TC (p= 0.001) and PLT (p= 0.048) levels were statistically significant between the two groups.There were differences in TC (p= 0.00001) and PLT (p= 0.031) levels between the case group and the control group in samples aged less than 45 years.There were differences in LDL (p= 0.00002) and PLT (p= 0.022) levels between the two groups in samples older than 45 years.Compared with the control group, patients with alcohol-induced ONFH had HDL (p = 0.002).LDL (p= 0.00002);The level of PLT (p= 0.0001) was significantly different.HDL (p = 0.005) was found in alcohol-induced ONFH patients younger than 45 years of age.The PLT level (p=0.045) was different from that of the control group.There was a difference in LDL (p= 0.000003) levels between control and alcohol-induced ONFH patients older than 45 years.The older the onset age, the TC in vivo;HDL;LDL;ApoA1;ApoB;The lower the PLT level.With the prolongation of the onset time, the PLT level in the patient's body is decreasing continuously.Conclusion: The changes of biochemical indexes are closely related to the occurrence of non-traumatic ONFH. Our research can provide a new direction for the prevention of ONFH.

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Section: Discussionsupporting

confidence: 42%

Index Analysis of Osteonecrosis and Related Causes

Cao

et al. 2020

Preprint

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“…Nevertheless, it has been found in clinical practice that only some people who drink excessively suffer from femoral head necrosis, which suggested that genetic susceptibility may contribute to the occurrence of alcoholic ONFH. Meanwhile, a large number of reports confirmed that genetic variants were related to alcoholic ONFH predisposition (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

The polymorphisms of MIR31HG gene is correlated with alcohol-induced osteonecrosis of the femoral head in Chinese Han male population

et al. 2022

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BackgroundAlcoholic osteonecrosis of the femoral head (ONFH) is a multifaceted illness that seriously disturbs the patients’ quality of life. The role of lncRNAs in alcoholic ONFH has attracted widespread attention in recent years. This study mainly explored whether MIR31HG polymorphism affects the risk of ONFH.MethodsThere were 733 males (308 alcohol-induced ONFH patients and 425 healthy controls). Seven single nucleotide polymorphisms from MIR31HG were genotyped using the Agena MassARRAY platform. Odds ratio (OR) and 95% confidence intervals (CI) via logistic regression was applied to assess the contribution of MIR31HG variants to alcoholic ONFH susceptibility.ResultsWe found that rs10965059 was related to a lower risk of alcoholic ONFH in the overall, age, and necrotic sites analysis. Rs10965064 also showed a risk-reducing effect in the occurrence of alcoholic ONFH patients older than 40 years old.ConclusionsWe confirmed that MIR31HG variants have a significant correlation with the occurrence of alcoholic ONFH among the Chinese Han male population. our findings may provide new ideas for understanding the effect of MIR31HG on the prevention and diagnosis of alcoholic ONFH.

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“…According to statistics in China, 30.7% of ONFH cases are caused by alcohol [11]. Thereinto, genetic polymorphisms of some genes played critical roles in the occurrence of alcohol-induced ONFH [12][13][14][15][16][17], such as MMP20, RETN, ApoB, ApoA1, NOS3.…”

Section: Introductionmentioning

confidence: 99%

Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

Yong-chang

Cao

Gong

et al. 2020

BMC Musculoskelet Disord

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Background: Osteonecrosis of the femoral head (ONFH) is a complicated disease associated with trauma, hormone abuse and excessive alcohol consumption. Polymorphisms of long non-coding RNAs have been also linked with the development of ONFH. Our research aimed to explore the relationship between CARMEN (Cardiac Mesoderm Enhancer-Associated Non-Coding RNA) variants and ONFH risk. Methods: Our study used Agena MassARRAY Assay to genotype 6 selected single nucleotide polymorphisms (SNPs) in 731 participants (308 alcohol-induced ONFH patients and 423 controls). We used odds ratios (ORs) and 95% confidence intervals (CIs) to calculate the effect of gene polymorphisms on the occurrence of alcohol-induced ONFH by logistic regression analysis and haplotype analysis. Results: Our overall analysis illustrated that rs13177623 and rs12654195 had an association with a reduced risk of ONFH after adjustment for age and gender. We also found that rs13177623, rs12654195 and rs11168100 were associated with a decreased susceptibility to alcohol-induced ONFH in people ≤45 years. In addition, the necrotic sites stratification analysis showed that rs12654195 was only found to be related to alcohol-induced ONFH risk in the recessive model. In patients with different clinical stages, rs353300 was observed to be associated with a higher incidence of ONFH. Individuals with different genotypes of rs13177623, rs12654195 and rs11168100 had significantly different clinical parameters (cholinesterase, globulin, percentage of neutrophils and the absolute value of lymphocytes). Conclusions: Our data provided new light on the association between CARMEN polymorphisms and alcoholinduced ONFH risk in the Chinese Han population.

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Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head

Cited by 5 publications

References 22 publications

Index Analysis of Osteonecrosis and Related Causes

Index Analysis of Osteonecrosis and Related Causes

The polymorphisms of MIR31HG gene is correlated with alcohol-induced osteonecrosis of the femoral head in Chinese Han male population

Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

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