Index Analysis of Osteonecrosis and Related Causes

Abstract

Background: The pathogenesis of non-traumatic osteonecrosis of the femoral head (ONFH ) is related to the interruption of blood supply caused by lipid metabolism and hypercoagulability. The purpose of this study was to explore the relationship between clinical biochemical parameters and non-traumatic ONFH. Methods: The basic information and biochemical indexes of 1292 patients with non- traumatic ONFH and 1880 healthy controls were collected. SPSS software (version 22.0) was used to process and analyze the data. T-test was used for quantitative analysis. Chi-square test was used for categorical variables.p< 0.05 were the index with statistical significance. Results: In the population sample, TC (p= 0.00004), LDL (p= 0.014) and PLT (p= 0.000005) levels were statistically significant between the two groups.In men, levels of TC (p = 0.004), LDL (p= 0.011), and PLT (p= 0.00005) were statistically significant between the two groups.In women, TC (p= 0.001) and PLT (p= 0.048) levels were statistically significant between the two groups.There were differences in TC (p= 0.00001) and PLT (p= 0.031) levels between the case group and the control group in samples aged less than 45 years.There were differences in LDL (p= 0.00002) and PLT (p= 0.022) levels between the two groups in samples older than 45 years.Compared with the control group, patients with alcohol-induced ONFH had HDL (p = 0.002).LDL (p= 0.00002);The level of PLT (p= 0.0001) was significantly different.HDL (p = 0.005) was found in alcohol-induced ONFH patients younger than 45 years of age.The PLT level (p=0.045) was different from that of the control group.There was a difference in LDL (p= 0.000003) levels between control and alcohol-induced ONFH patients older than 45 years.The older the onset age, the TC in vivo;HDL;LDL;ApoA1;ApoB;The lower the PLT level.With the prolongation of the onset time, the PLT level in the patient's body is decreasing continuously.Conclusion: The changes of biochemical indexes are closely related to the occurrence of non-traumatic ONFH. Our research can provide a new direction for the prevention of ONFH.

Use of microRNAs as Diagnostic, Prognostic, and Therapeutic Tools for Glioblastoma

“…miR-7, for example, can be an oncomiR or a tumor suppressor gene, and it also regulates distinct genes in a cellular context-dependent manner [32][33][34][35]. Notably, miR-7 expression levels present dynamic changes both in normal CNS development [36][37][38][39] and in some CNS disorders [40,41], including GB [32,[42][43][44][45][46][47][48], and, as these facts are true for miR-7, they have also been reported for most of the miRNAs involved in tumorigenesis.…”

“…In another study, miR-7 was shown to negatively regulate the T-box 2 (TBX2) gene, whose expression is upregulated in GB tissue; thus, miR-7 downregulation and TBX2 overexpression in GB results in both EMT induction and increased cell invasion of GB in vitro [90]. miR-7 was also shown to target the special at rich sequence binding protein 1 (SATB1) gene, the expression of which promotes GB cell migration and invasion [48], whereas focal adhesion kinase (FAK) downregulation by miR-7 results in decreased invasion of GB cells [47]. Notably, miR-7-5p suppresses stemness and enhances TMZ sensitivity of drug-resistant GB cells by targeting the yin and yang 1 (YY1) TF [43].…”