Significance of vascular endothelial growth factor expression in skin melanoma

Gajanin, Vesna; Krivokuća, Zdenka; Kostić, Kristina; Gajanin, Radoslav; Sladojević, Igor

doi:10.2298/vsp1009747g

Cited by 5 publications

(11 citation statements)

References 17 publications

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“…The highest percentage of patients with histological stage pT1a demonstrated greatest intensity of VEGF staining, whereas the maximum value of the average level of VEGF staining was detected, in decreasing order, in patients with stage pT2a, pT3b and pT4b. In the study of Gajanin et al 11 the most intensive staining for VEGF was detected in patients with pT3b / pT4b histological stage. They found a significant difference in the intensity of expression of VEGF staining in patients with melanomas in different pT stages (p < 0.05).…”

Section: Discussionmentioning

confidence: 90%

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Association of vascular endothelial growth factor expression with patohistological parameters of cutaneous melanoma

et al. 2016

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Section: Discussionmentioning

confidence: 90%

“…The role of VEGF in metastatic melanoma has been the main focus of research in recent years [11][12][13][14][15] . It has been shown that VEGF stimulates tumor angiogenesis in autocrine and paracrine fashion.…”

Section: Introductionmentioning

confidence: 99%

Association of vascular endothelial growth factor expression with patohistological parameters of cutaneous melanoma

et al. 2016

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“…The underexpression of CCND1 and RAC1 , which are generally overexpressed in neoplasms, in the datasets under study might indicate that these genes were not associated with leukemogenesis in the patient samples used for the expression study. Although most cancers show high expression levels of VEGF , in some cancers such as benign forms of melanoma [71] and in cancers with high microsatellite instability [72] lower expression of VEGFA are associated with better prognosis. The underexpression of VEGFA in the T-ALL datasets examined may also be indicative of favorable prognosis in the T-ALL patients.…”

Section: Discussionmentioning

confidence: 99%

In Silico Evidence of Signaling Pathways of Notch Mediated Networks in Leukemia

Jamil

Jayaraman

Raghunatha

et al. 2012

Computational and Structural Biotechnology Journal

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Notch signaling plays a critical role in cell fate determination and maintenance of progenitors in many developmental systems. Notch receptors have been shown to be expressed on hematopoietic progenitor cells as well as to various degrees in peripheral blood T and B lymphocytes, monocytes, and neutrophils. Our aim was to understand the protein interaction network, using Notch1 protein name as query in STRING database and we generated a model to assess the significance of Notch1 associated proteins in Acute Lymphoblastic Leukemia (ALL). We further analyzed the expression levels of the genes encoding hub proteins, using Oncomine database, to determine their significance in leukemogenesis. Of the forty two hub genes, we observed that sixteen genes were underexpressed and eleven genes were overexpressed in T-cell Acute Lymphoblastic samples in comparison to their expression levels in normal cells. Of these, we found three novel genes which have not been reported earlier- KAT2B, PSEN1 (underexpressed) and CDH2 (overexpressed).These three identified genes may provide new insights into the abnormal hematopoietic process observed in Leukemia as these genes are involved in Notch signaling and cell adhesion processes. It is evident that experimental validation of the protein interactors in leukemic cells could help in the identification of new diagnostic markers for leukemia.

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“…The magnitude of the control clearly indicated a synergestic rather than an additive effect of the combined radiation + As 2 O 3 , thus suggested that when used as a radiosensitizer, As 2 O 3 can significantly improve the therapeutic efficacy. Furthermore, we explored the possible mechanisms of radiosensitization involving VEGF and Ku70, two molecular markers known to affect radiosensitivity [26][27][28][29][30][31][32]. The molecular mechanisms of the radiosensitization effect of As 2 O 3 were elucidated by evaluating the expression of VEGF and Ku70 with RT-PCR and immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

“…The molecular mechanisms of the radiosensitization effect of As 2 O 3 were elucidated by evaluating the expression of VEGF and Ku70 with RT-PCR and immunohistochemistry. VEGF plays a significant part in the formation of the tumor blood vessels and stimulates the growth and metastasis of tumor [26,27]. Elevated serum VEGF levels are associated with poor response and a shorter time to progression in patients with cervical cancer treated with radiotherapy [28].…”

Section: Discussionmentioning

confidence: 99%

Radiosensitization of cervical cancer xenografts by arsenic trioxide and the role of VEGF and Ku70

Ren

Tey

et al. 2012

J Radiat Oncol

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Objective The aim of this study is to explore the effect of arsenic trioxide (As 2 O 3 ) on radiosensitivity in cervical carcinoma xenografts and the possible underlying mechanisms of vascular endothelial growth factor (VEGF) and Ku autoantigen protein p70 (Ku70). Methods The tumor-bearing C57BL/6mouse model was established by injecting U14 cervical carcinoma cells into the right infra-axillary dermis of 40 mice. The mice were randomized into four groups: (1) control group (peritoneal injection, 0.2 ml of 0.9% normal saline); (2) As 2 O 3 only group (peritoneal injection, 2.0 mg/kg, 0.2 ml As 2 O 3 ); (3) irradiation only group (peritoneal injection 0.9%NS, 0.2 ml+6 MeV electron beam, 10 Gy); and (4) As 2 O 3 + irradiation group (peritoneal injection, 2.0 mg/kg, 0.2 ml As 2 O 3 +6 MeV electron beam, 10 Gy). The mice were sacrificed 25 days after randomisation. U14 cervical tumors from the mice were harvested and weighed. Response to treatment using radiation and/or As 2 O 3 was evaluated by extent of inhibition (i.e., growth inhibition rate) of tumor growth. VEGF and Ku70 mRNA expression and protein levels were evaluated by RT-PCR and immunohistochemistry, respectively. Results As 2 O 3 + irradiation was found to significantly increase the inhibition of tumor growth. The growth inhibition rates in As 2 O 3 only, irradiation only, and As 2 O 3 + irradiated groups were 10.48%, 30.30%, and 73.15%, respectively (p <0.05). The combination also significantly downregulated the expression of VEGF and Ku70 in irradiated cervical carcinoma xenografts as compared to the control group, As 2 O 3 only group, or irradiation only group (p <0.05). Conclusions Arsenic trioxide effectively sensitizes the cervical carcinoma xenografts to ionizing irradiation. Downregulation of the expression of VEGF and Ku70 is likely to play an important role.

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Significance of vascular endothelial growth factor expression in skin melanoma

Cited by 5 publications

References 17 publications

Association of vascular endothelial growth factor expression with patohistological parameters of cutaneous melanoma

Association of vascular endothelial growth factor expression with patohistological parameters of cutaneous melanoma

In Silico Evidence of Signaling Pathways of Notch Mediated Networks in Leukemia

Radiosensitization of cervical cancer xenografts by arsenic trioxide and the role of VEGF and Ku70

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