The question whether a seasonal climate trend (e.g., the increase of summer temperatures in Antarctica in the last decades) is of anthropogenic or natural origin is of great importance for mitigation and adaption measures alike. The conventional significance analysis assumes that (i) the seasonal climate trends can be quantified by linear regression, (ii) the different seasonal records can be treated as independent records, and (iii) the persistence in each of these seasonal records can be characterized by short-term memory described by an autoregressive process of first order. Here we show that assumption ii is not valid, due to strong intraannual correlations by which different seasons are correlated. We also show that, even in the absence of correlations, for Gaussian white noise, the conventional analysis leads to a strong overestimation of the significance of the seasonal trends, because multiple testing has not been taken into account. In addition, when the data exhibit long-term memory (which is the case in most climate records), assumption iii leads to a further overestimation of the trend significance. Combining Monte Carlo simulations with the Holm-Bonferroni method, we demonstrate how to obtain reliable estimates of the significance of the seasonal climate trends in long-term correlated records. For an illustration, we apply our method to representative temperature records from West Antarctica, which is one of the fastest-warming places on Earth and belongs to the crucial tipping elements in the Earth system.climate | long-term persistence | seasonal trends | statistical significance | multiple testing I n the last decades, estimations of the magnitude of deterministic trends in natural records have become an important issue, due to anthropogenic global warming (1). Although the estimation of a trend by linear regression is an easy task, the estimation of its statistical significance and its error bar is complicated, because the natural persistence of the records also becomes an issue.In the absence of persistence (white noise) as well as in shortterm persistent records, the distribution of the trend follows a Student's t distribution from which the significance S , its p value p = 1 − S , and the error bars of the trend can be determined (see, e.g., refs. 2-4 and Methods). In many natural records like temperature data, river flows, sea level heights, wind fields, midlatitude cyclones, or Antarctic sea ice extent, the assumption of white noise or short-term memory is not valid, due to strong longterm memory in the data (5-27) (Methods).Here we consider seasonal temperature records. A "season" can be a calendar day (without leap day), a week, a month, or combinations of months like meteorological winter, spring, summer, and autumn. Let us consider a daily mean temperature record with a length of L years. When a season is defined as a certain calendar day, the corresponding seasonal record consists of the L temperature data at that calendar day (e.g., January 10), in chronological order. By definition, ...