Significance of serum-soluble CD95 (Fas/APO-1) on prognosis in renal cell cancer patients

Abstract

Summary Serum-soluble CD95 (sCD95) levels for 72 renal cell cancer patients were significantly higher than those of 17 healthy donors. Twenty-one of 72 patients had elevated (defined as more than mean of healthy donors + 2 s.d.) sCD95. The disease-specific survival rate was significantly lower in the elevated sCD95 group. Serum sCD95 level was shown to be an independent prognostic factor by univariate and multivariate analysis, indicating a possible significant role in determining treatment strategies.

Regulation of Fas-Mediated Apoptosis in Neutrophils after Surgery-Induced Acute Inflammation

“…Many previous studies have reported that serum sFas is elevated in patients with malignant disease [39,40]. Several studies have been performed showing an increased sFas serum concentration associated with a poor prognosis in patients suffering malignant disease [41,42]. Previous studies have also reported that the sFas levels were increased in the plasma from patients with inflammatory situations such as SIRS [23,32,42,43] and coronary bypass surgery [33].…”

Absence of Bcl-2 and Fas/CD95/APO-1 predicts the response to immunotherapy in metastatic renal cell carcinoma

“…Renal cell cancer has been reported to harbour mutations in exons 7 and 9 of the Fas gene (Takayama et al, 2002). Indeed, we have previously demonstrated that RCC patients have elevated levels of soluble Fas, which was an independent negative prognostic factor (Kimura et al, 1999). In addition to inducing apoptosis, Fas can also promote cell growth or differentiation (Mapara et al, 1993;Owen-Schaub et al, 1994;Budd, 2002).…”

“…We previously investigated several apoptotic factors, together with their signalling mechanism and reported the prognostic value of serum soluble Fas in RCC patients (Kimura et al, 1999). Furthermore, the frequent expression of Bcl-2 and the absence of p53 gene alterations were found in these RCC specimens (Tomita et al, 1996b).…”

Soluble Fas in malignant pleural effusion and its expression in lung cancer cells

“…Furthermore, a correlation of the serum sFas level with the prognosis of patients was observed in several studies. [22][23][24][25] However, little is known about the level of sFas in malignant pleural effusion and the sFas expression of lung cancer.…”