Significance of Serum Fibrin/Fibrinogen Degradation Products Measured by a Highly Sensitive ELISA Method in Renal Diseases

Shibata, Tetsuo; Magari, Yasuo; Perparim, Kamberi; Yasumori, Ryokichi; Nasu, Masaru

doi:10.1159/000188973

Cited by 2 publications

(2 citation statements)

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“…18,19 Other studies have identified renal dysfunction as a state of activated coagulation due to the elevated D-dimer levels, which are not cleared by the kidney. 20,21 Although fibrinogen levels are thought to be primarily determined by fibrinogen synthesis, Lane and colleagues 22 found the metabolism and elimination of fibrinogen to be decreased in renal insufficiency and ESRD. The role of the kidney in the elimination of these biomarkers has not been established, nor is it known whether mild to moderate renal insufficiency has an impact on their clearance.…”

Section: Discussionmentioning

confidence: 99%

Elevations of Inflammatory and Procoagulant Biomarkers in Elderly Persons With Renal Insufficiency

et al. 2003

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Background-Renal insufficiency has been associated with cardiovascular disease events and mortality in several prospective studies, but the mechanisms for the elevated risk are not clear. Little is known about the association of renal insufficiency with inflammatory and procoagulant markers, which are potential mediators for the cardiovascular risk of kidney disease. Methods and Results-The cross-sectional association of renal insufficiency with 8 inflammatory and procoagulant factors was evaluated using baseline data from the Cardiovascular Health Study, a population-based cohort study of 5888 subjects aged Ն65 years. C-reactive protein, fibrinogen, factor VIIc, and factor VIIIc levels were measured in nearly all participants; interleukin-6, intercellular adhesion molecule-1, plasmin-antiplasmin complex, and D-dimer levels were measured in nearly half of participants. Renal insufficiency was defined as a serum creatinine level Ն1.3 mg/dL in women and Ն1.5 mg/dL in men. Multivariate linear regression was used to compare adjusted mean levels of each biomarker in persons with and without renal insufficiency after adjustment for other baseline characteristics. Renal insufficiency was present in 647 (11%) of Cardiovascular Health Study participants. After adjustment for baseline differences, levels of C-reactive protein, fibrinogen, interleukin-6, factor VIIc, factor VIIIc, plasmin-antiplasmin complex, and D-dimer were significantly greater among persons with renal insufficiency (PϽ0.001). In participants with clinical, subclinical, and no cardiovascular disease at baseline, the positive associations of renal insufficiency with these inflammatory and procoagulant markers were similar. Conclusion-Renal

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Section: Discussionmentioning

confidence: 99%

Elevations of Inflammatory and Procoagulant Biomarkers in Elderly Persons With Renal Insufficiency

et al. 2003

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“…We previously reported the results of measurement of serum or urinary total FDP and FDP D -dimer in renal diseases using a newly established sensitive enzyme-linked immunosorbent assay (ELISA) [2, 3, 4]. …”

Section: Introductionmentioning

confidence: 99%

Urinary Fibrin/Fibrinogen Degradation Product E (FDP-E) Measured by a Highly Sensitive ELISA Method in Renal Diseases

Shibata¹,

Magari

Mizunaga

et al. 1998

Nephron

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Significance of Serum Fibrin/Fibrinogen Degradation Products Measured by a Highly Sensitive ELISA Method in Renal Diseases

Cited by 2 publications

References 3 publications

Elevations of Inflammatory and Procoagulant Biomarkers in Elderly Persons With Renal Insufficiency

Elevations of Inflammatory and Procoagulant Biomarkers in Elderly Persons With Renal Insufficiency

Urinary Fibrin/Fibrinogen Degradation Product E (FDP-E) Measured by a Highly Sensitive ELISA Method in Renal Diseases

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