Urinary Fibrin/Fibrinogen Degradation Product E (FDP-E) Measured by a Highly Sensitive ELISA Method in Renal Diseases

Shibata, Tetsuo; Magari, Yasuo; Mizunaga, S; Ishii, Terukazu; Tomo, Tadashi; Yasumori, Ryokichi; Nasu, Masaru; Taguchi, Takashi

doi:10.1159/000045107

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…In this study, increased levels of different renal biomarkers, such as creatinine, urea, cystatin C, eGFR and UAE, were observed in patients with high D-Dimer levels. The association between renal dysfunction and increased levels of D-Dimer in DM1 patients may be explained by the increased synthesis of D-Dimer, but not by the reduced loss of D-Dimer in urine, since it has been shown that patients with diabetic kidney disease show higher urinary levels of D-Dimer than healthy individuals due to proteinuria (24). Proteinuria should also be responsible for the loss of important natural anticoagulant proteins, such as antithrombin, protein C and protein S, intensifying the hypercoagulability status and the production of D-Dimer (25).…”

Section: Discussionmentioning

confidence: 99%

Association of different biomarkers of renal function with D-dimer levels in patients with type 1 diabetes mellitus (renal biomarkers and D-dimer in diabetes)

Domingueti¹,

Fóscolo²,

Dusse³

et al. 2018

Archives of Endocrinology and Metabolism

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Objective This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated. Results Cystatin C presented a better association [OR of 9.8 (3.8-25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2-12.9), 8.4 (2.5-25.4), 9.1 (2.6-31.4) and 3.5 (1.4-8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapies.

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Section: Discussionmentioning

confidence: 99%

Association of different biomarkers of renal function with D-dimer levels in patients with type 1 diabetes mellitus (renal biomarkers and D-dimer in diabetes)

Domingueti¹,

Fóscolo²,

Dusse³

et al. 2018

Archives of Endocrinology and Metabolism

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“…The association between plasma D-dimer levels and renal dysfunction in DN may stem from an increase in plasma D-dimer synthesis rather than a reduction in urinary D-dimer excretion. It is noteworthy that DN patients with proteinuria have higher levels of urinary D-dimer than healthy individuals [ 22 ]. Natural anticoagulants such as antithrombin, protein C, and protein S can be lost via proteinuria, further exacerbating the hypercoagulable state and promoting plasma D-dimer production [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma D-dimer levels are associated with disease progression in diabetic nephropathy: a two-center cohort study

Yu,

Zhu,

Lin

et al. 2023

Renal Failure

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Background This study aimed to investigate the relationship between plasma D-dimer levels, clinicopathological features, and clinical outcomes in patients with biopsy-proven diabetic nephropathy (DN). Methods A total of 137 patients with biopsy-proven DN were enrolled in this two-center cohort study. Patients were stratified into tertiles based on plasma D-dimer levels. We investigated the relationship between plasma D-dimer levels and clinical outcomes, including a composite of death, a 40% decline in estimated glomerular filtration rate (e-GFR) from baseline, or end-stage renal disease (ESRD) (defined as e-GFR < 15 mL/min/1.73 m 2 or need for renal replacement therapy including hemodialysis, peritoneal dialysis, or kidney transplantation), assessed using Cox regression models with adjustment for confounders. Results At baseline, the mean age was 52.61 ± 11.63 years, and the mean e-GFR was 58.02 ± 28.77 mL/min/1.73 m 2 . During a median 26-month follow-up period, 65 (47% of patients) achieved clinical outcomes. Compared with the low plasma D-dimer level group, those with higher plasma D-dimer levels were more likely to have higher 24-h proteinuria ( p = .002), lower e-GFR ( p = .001), lower hemoglobin ( p = .001), a higher glomerular lesion class ( p = .03), and higher interstitial fibrosis and tubular atrophy (IFTA) scores ( p = .002). After adjustment for demographic, DN-specific covariates, and treatments, it was observed that a higher tertile of plasma D-dimer was nonlinearly associated with an increased risk of the clinical outcomes (Hazard Ratio (HR) for tertile 2 vs. 1, 1.7; 95% Confidence Interval (CI), 0.80–3.75; HR for tertile 3 vs. 1, 2.2; 95% CI, 0.93–5.27; p for trend = .001) in the Cox proportional hazards models. Conclusion In this study, DN patients with higher levels of plasma D-dimer had higher 24-h proteinuria, lower e-GFR, a higher glomerular lesion class, and higher IFTA scores. Furthermore, a high level of plasma D-dimer was nonlinearly associated with DN progression.

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“…Some studies have found an association between increased D-dimer levels and elevated DPE levels and decreased GFR in patients with diabetes mellitus [9,10]. It was postulated that the association between decreased GFR and elevated D-dimer levels in patients with diabetes mellitus was due to the increased formation of D-dimers rather than decreased urinary excretion of this marker, as it was shown that patients with DN had higher levels of D-dimers in their urine than healthy people [11]. It was also determined that important natural anticoagulant proteins (such as antithrombin, protein C, protein S) are lost in the urine during high proteinuria, which enhances the state of hypercoagulation and the formation of D-dimers [12].…”

Section: Characteristics Of Patientsmentioning

confidence: 99%

D-dimer as a potential predictor of thromboembolic and cardiovascular complications in patients with chronic kidney disease

Mykhaloiko¹,

Dudar²,

Mykhaloiko³

et al. 2020

Ukr.Biochem.J.

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The aim of the study was to evaluate the relationship between D-dimer levels and different biomarkers of renal diseases to identify the relationship between hypercoagulation and chronic kidney disease (CkD). To achieve this aim, we conducted a one-step prospective observational study involving 140 patients with CkD who were hospitali zed in Ivano-Frankivsk regional Clinical hospital in Ukraine during 2018-2019. of these patients, 100 patients (71.4%; 95% CI 53.4-76.7) had glomerulonephritis (GN) and 40 patients (28,6%; 95% CI 21.3-36.8) had diabetic nephropathy (DN). all patients underwent standard examination, which included general clinical, biochemical and instrumental research methods. D-dimer was quantitatively determined in blood serum by enzyme-linked immunosorbent assay (ElISa). The 140 patients were divided into two groups according to the level of D-dimers: normal level (<0.5 mg/l) and elevated level (≥0.5 mg/l). Elevated D-dimer levels were associated with an increased age of patients, decreased glomerular filtration rate, decreased blood albumin level, increased daily protein excretion and a tendency to develop thromboembolic complications during 1 year of monitoring. D-dimer is a biological marker that can detect hypercoagulation at an early preclinical stage in patients with CkD and identify patients with an increased cardiovascular risk, thereby promoting the earliest use of antiplatelet agents and anticoagulants and, consequently, it can reduce mortality .

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Urinary Fibrin/Fibrinogen Degradation Product E (FDP-E) Measured by a Highly Sensitive ELISA Method in Renal Diseases

Cited by 4 publications

References 2 publications

Association of different biomarkers of renal function with D-dimer levels in patients with type 1 diabetes mellitus (renal biomarkers and D-dimer in diabetes)

Association of different biomarkers of renal function with D-dimer levels in patients with type 1 diabetes mellitus (renal biomarkers and D-dimer in diabetes)

Plasma D-dimer levels are associated with disease progression in diabetic nephropathy: a two-center cohort study

D-dimer as a potential predictor of thromboembolic and cardiovascular complications in patients with chronic kidney disease

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