Significance of Resveratrol in Clinical Management of Chronic Diseases

Abstract

Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.

Effect of resveratrol and pterostilbene on aging and longevity

“…As such, aging is a major risk factor for noninfectious chronic disease including diabetes, cardiovascular disease, cancer, and neurological disease . Over the past 20 years, several studies suggest that foods rich in polyphenols are associated with protection against age‐related disease (atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension, and Alzheimer's disease) . Resveratrol and pterostilbene are natural nutrients from grapes and blueberries, respectively.…”

Microsomal pre‐receptor cortisol production is inhibited by resveratrol and epigallocatechin gallate through different mechanisms

“…However, no general conclusion can be drawn about the safety range and therapeutic effectiveness, as the consequences are sometimes contradictory, data on capsule versus food form consumption is conflicting and there are uncertain effects of long term dosing. Our results show a novel molecular mechanism, however, inhibition of the cortisone reducing machinery of the ER is only effective in an early stage of the metabolic syndrome, as the importance of pre‐receptor cortisol activation is diminishing in parallel with the development of the disease. This highlights resveratrol, along with EGCG as an important preventive agent.…”

Sirtuins in wound healing

“…SIRTs activators have been found in nature and synthesized such as RSV and its derivatives [60] . The effect of RSV on wound healing and chronic diseases has been evaluated not only in animal model and human EpiDerm full thickness model, but also in clinical applications [61][62][63] . Taken together, SIRTs are involved in orchestrated wound healing processes and its activation provides an approach for acceleration of wound therapy.…”