Significance of resection margin as a risk factor for local control of early stage breast cancer

Abstract

Introduction. Breast conserving surgery combined with sentinel node biopsy represents currently the gold standard of treatment for early breast cancer. Although breast conserving surgery has been a widely accepted method for many years, there remain some highly controversial unresolved issues. The present analysis focused on the resection margin as one of the key factors for local control of the disease. Methods. Patient disease free survival and overall survival were collected from patients undergoing breast conserving surgery from 2004 to 2009 at the Department of Surgery Atlas hospital Zlin, Czech Republic. All patients with resection margin less then 5 mm were re-resected to achieve this clear resection margin of 5mm or more. Disease free survival (more specifically local relapse free survival, metastasis free survival and regional free survival) and overall survival were assessed. Results. The data on 330 patients were analyzed and 286/330 cases had complete follow-up. After a median follow-up of 70 months, 7 patients with isolated local relapse were identified (2.44%), 13 patients with distant metastasis without local relapse (4.54%) and 2 patients with relapse in the axilla without local relapse in the breast (0.7%). Conclusion.The final decision about the extent of resection margin remains controversial but based on the data on local control presented here it seems reasonable to increase the criteria for a clear resection margin to 5 mm.

Multimodal Optical Coherence Tomography for Intraoperative Evaluation of Tumor Margins and Surgical Margins in Breast-Conserving Surgery

“…Various authors discuss different margin width ranges — from 1 to 10 mm. The majority (65%) of surgeons consider resection margins of 2 mm or above to be acceptable, although 35% of specialists believe that the width of under 2 mm is acceptable [ 27 , 28 ]. It is expected that OCT application will allow surgical oncologists to obtain new important information that can improve reliability of optimal resection margins and sensitivity of tumor cells detection at the tumor surgical margin in BCS.…”

Effects of Polyphenols on Cell Viability of Selected Varieties of Grapes Berries and Pomace

“…Positive effect of PhC can be used in treatment and prevention of cancer [Zinov'eva et al 2011] in combination with standard procedures as surgery [Gatek et al 2013], neurodegenerative disorders [Mandel et al 2004], coronary heart diseases [Sharif et al 2010] and strokes [Neto 2007]. Mentioned effects are connected to the attribute of PhC which affect signal transduction pathways, causing inhibition of cell growth, enhanced apoptosis [Lambert et al 2005], arresting cell cycle progression or triggering cell death [Sharif et al 2010].…”

Resection margin status during organ-sparing surgery for breast cancer

“…Диапазон, дискутируемой разными авторами, ширины резекции колеблется от 1 до 10 мм. Однако при ширине резекции 5 мм 30% больных подлежат ререзекции [19][20][21][22][23][24][25][26][27].…”