Significance of multiple preoperative laboratory abnormalities as prognostic indicators in patients with urothelial carcinoma of the upper urinary tract following radical nephroureterectomy

Abstract

These findings suggest that it is important to consider laboratory abnormalities, particularly the De Ritis ratio and NLR, to predict disease recurrence following RNU in patients with clinically localized UUTUC.

Prognostic Role of Preoperative C-Reactive Protein in Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy - An Updated Meta-Analysis

“…And 262 articles were excluded by screening the title and abstract. The remaining 50 articles were read in full text, and it is 13 studies [11][12][13][14][15][16][17][18][19][20][21][22][23] that satis ed the inclusion criteria and were analyzed in our meta-analysis. The speci c literature screening process was displayed in Figure 1.…”

“…Compared with You L and his colleagues' study [9], we recon rmed that elevated preoperative CRP had a poor impact on RFS and CCS of patients with UTUC and found elevated CRP also played a signi cant adverse effect on OS in patients with UTUC treated by RNU, which greatly differed from theirs. On the basis of their research, in which there were 2 studies [3,24] only containing outcomes in the univariate analysis, we retrieved another 8 relevant studies [12][13][14][15][16][17][18][19] including sound results in multivariate analysis, and, since then, 1233 cases were added to our studies. What's more, we found that authors neglecting the heterogeneity between all studies used a random-effects model to pool all outcomes of interest in their analysis, which may have a certain in uence on the accuracy of the nal results.…”

The prognostic value of De Ritis (AST/ALT) ratio in patients after surgery for urothelial carcinoma: a systematic review and meta-analysis

“…While in patients with surgically treated UC, the prognostic value of De Ritis ratio is still unclear. Nishikawa et al found that elevated De Ritis ratio is associated with recurrence-free survival (RFS) in patients with UC, while the other study did not detect the significant association between elevated De Ritis ratio and RFS [15,16]. As a result, we conducted this systematic review and meta-analysis to explore the prognostic value of preoperative De Ritis ratio in patients after surgery for UC.…”

“…After screening titles and abstracts of the remaining 299 studies, 20 studies were reviewed comprehensively. Finally, a total of 8 studies incorporating 3949 patients were included in the quantitative synthesis [15,16,[19][20][21][22][23][24]. The flow diagram of the study search and selection is presented in Fig.…”

“…Of the enrolled 8 studies, all are published in recent 3 years and are retrospective. Five studies involved the patients with UTUC and underwent RUN [15,16,20], 3 studies involved patients with BC and treated by RC [19,21,22]. The median ages of patients were similar, ranging from 61 to 69.…”