Abstract:MiB-1 immunostaining may facilitate recognition of developing adenocarcinoma in cervical smear screening. In a retrospective analysis of prospectively collected data of 170 patients with atypical endocervical glandular cells and with repeat smears, archival Papanicolaou-stained smears were restained for MiB-1 and classified for the presence of preneoplastic changes of MiB-1 positive epithelial fragments. The results of classification based on MiB-1 positive epithelial fragments corresponded "roughly" with cyto… Show more
“…Ki-67 incidence in Pap smear samples with endocervical granular atypia showed that analyzing Ki-67 status for distinguishing neoplastic and non-neoplastic lesions was helpful method (Boon et al, 2004).…”
“…Ki-67 incidence in Pap smear samples with endocervical granular atypia showed that analyzing Ki-67 status for distinguishing neoplastic and non-neoplastic lesions was helpful method (Boon et al, 2004).…”
“…In preliminary experiments, there was no reactivity following 1% acid alcohol treatment prior to immunostaining. Microwave pre‐treatment is essential to immunocytochemistry in previously stained FNA smears both to destain and to enhance immunoreaction 5–7 …”
Section: Discussionmentioning
confidence: 99%
“…Microwave pre-treatment is essential to immunocytochemistry in previously stained FNA smears both to destain and to enhance immunoreaction. [5][6][7] There has been controversy over the optimal conditions to evaluate Ki-67 in FNA smears in samples from humans. Some authors recommend immediate fixation without air-drying of smears.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand cytological samples are easy to obtain in clinical settings. If it is possible to evaluate tumour markers in fine needle aspiration (FNA) smears, they would be a valuable adjunct for evaluation of tumour behaviour 4–17 . Zuccari et al.…”
Section: Introductionmentioning
confidence: 99%
“…If it is possible to evaluate tumour markers in fine needle aspiration (FNA) smears, they would be a valuable adjunct for evaluation of tumour behaviour. [4][5][6][7][8][9][10][11][12][13][14][15][16][17] Zuccari et al 17 applied Ki-67 antibody to ethanol-fixed imprint smears to show that the marker can be assessed in both FNA smears and histological samples. This study evaluates the possibility of retrieving Ki-67 antigen in Diff-Quik-stained smears from canine mammary gland tumours.…”
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