Diagnostic Value of Protein Ki67 (MIB-1) in Atypical Pap Smears of Postmenopausal Women

The Relationship between Expression of p70s6k with Radiotherapy Response in Cervical Cancer

“…High MIB-1 indices that appear in the High Expression group Table 1 are also relevant for studies of breast cancer and in-vitro studies using mammalian cells [19,20]. A high MIB-1 index indicates that the fraction of cancer cells growing is high [17]. The high p53 index in the High Expression group in Table 1 was due to the presence of most expression of p53 in cervical cancer in mutant rather than in wild type, even though DNA sequencing analysis was not performed.…”

“…After incubation with antibodies, the sections were washed with PBS for 15 minutes, and incubated with secondary antibody (Labeled Polymer HRP from DakoCytomation) for 60 minutes at room temperature. Then, the sections were washed with PBS for 10 minutes, developed with 3,3'-diaminobenzidine tetrahydrochloride for 30 seconds, slightly counterstained with hematoxylin, dehydrated, and mounted; this technique was done with some modifications from the original method [17]. p70s6k expression is observed in the nucleus and cell cytoplasm.…”

Atrophic Pap Smears, Differential Diagnosis and Pitfalls: A Review

“…Although atrophic smears may contain anucleated cells due to uterine prolapse, the presence of atypical parakeratotic cells or cells with atypical nuclei and keratinized cytoplasm should be interpreted with extreme caution. Although the application of the above mentioned cytologic criteria will be useful in most of these difficult cases, some investigators recommended that utilization of immunocytologic markers such as Ki67 would be effective in some of the problematic cases (20,21). Other studies proposed that immunocytochemical detection of P16 and ki67 acts as a more accurate route in establishing a correct diagnosis (22)(23)(24).…”

Staphylococcus aureus: resistance pattern and risk factors

“…[5][6][7][8][9] Traditionally, MRSA was identified infrequently from patients in the community, but over the last few years reports have documented increases in communityacquired MRSA, which may suggest a changing in epidemiology. [10][11][12][13][14][15] Colonized personnel can serve as a reservoir for the nosocomial spread of MRSA. Most transmission of MRSA from patient to patient is thought to be mediated by transiently colonized healthcare workers, although airborne dispersal and transmission through contacts with contaminated surfaces may also be important.…”