Significance of intima-media thickness in femoral artery in the determination of calcaneus osteo-sono index but not of lumbar spine bone mass in healthy Japanese people

Abstract

The aim of this cross-sectional study was to investigate whether physical activity and local arterial thickening may affect bone metabolism. To analyze the effects of physical activity and atherosclerosis on bone in healthy Japanese people, health-related quality of life (HRQL) and local arterial thickening were assessed by means of the Medical( )Outcomes Study 36-item Short Form (SF-36), and intimal-medial thickness (IMT) in common carotid artery (CA) and femoral artery (FA), respectively. Bone mineral density (BMD) in lumbar spine was measured by dual X-ray absorptiometry and the osteo-sono assessment index (OSI) of the calcaneus by ultrasound. Healthy subjects (106 male and 154 female) were recruited from those who participated in a local health check program at the Osaka City University Hospital. A significant correlation existed between lumbar spine BMD and calcaneus OSI (r=0.551, P<0.0001). Among various scores in SF-36, only physical functioning score correlated weakly but significantly in a positive manner with lumbar spine BMD (rho=0.156, P=0.0147) and calcaneus OSI (rho=0.190, P=0.0024). Lumbar spine BMD correlated negatively with FA IMT (rho=-0.191, P=0.0027) whereas calcaneus OSI with FA IMT (rho=-0.199, P=0.0014). Multiple regression analyses revealed a significant association between FA IMT and calcaneus OSI, whereas lumbar spine BMD did not correlate significantly with FA or CA IMT. When subjects were restricted to female, FA IMT, but not CA IMT, still showed tendency against independent factors negatively associated with calcaneus OSI. Furthermore, lumbar spine BMD, but not calcaneus OSI, was weakly but significantly associated with increased physical functioning score independently. In conclusion, it was suggested that physical activity may affect bone strength in lumbar spine and calcaneus and that FA IMT might be a significant determinant of bone strength in calcaneus, but not in lumbar spine, in healthy Japanese subjects.

Beneficial effect of risedronate on arterial thickening and stiffening with a reciprocal relationship to its effect on bone mass in female osteoporosis patients: A longitudinal study

“…Since improvement of baPWV and CA-IMT correlated with FN BMD, this tends to rule out a direct effect of risedronate on vascular cells. The significant association of atherosclerosis markers with FN BMD might also be ascribed to data indicating a confounding effect of physical activity on bone mass, particularly for weight-bearing bones such as the FN (Yamada et al, 2005), and on atherosclerosis markers (Kumeda et al, 2002). No significant difference in the rate of drug administration existed between two groups of patients.…”

Bone Mineral Density as a Predictor of Atherosclerosis and Arterial Wall Stiffness in Obese African-American Women

“…Mangiafico et al [8] and Sabit et al [12] also showed a significant relationship between PWV and bone mineral loss. However, Yamada et al [14] did not find an independent relationship between lumbar BMD or osteo-sono index and PWV. Similarly, the present study did not demonstrate a correlation between PWV and bone mass loss measured by DEXA scan.…”

“…The association between atherosclerosis and bone mineral loss appears to be age dependent. Yamada et al [14] showed that femoral artery IMT was independently associated with bone strength in the calcaneus but not in the lumbar spine. Kammerer et al [22] showed that CIMT was associated negatively with BMD in older but not in younger subjects.…”

“…Studies relating the degree of atherosclerosis and bone mineral loss have shown variable results [14,22]. The association between atherosclerosis and bone mineral loss appears to be age dependent.…”

Higher serum bone alkaline phosphatase as a predictor of mortality in male hemodialysis patients

“…We have shown that abdominal aortic calcification is significantly associated with all-cause mortality in maintenance hemodialysis patients (Okuno et al, 2007). Reduced bone mineral density (BMD) has been linked to increased arterial thickness and stiffness based on increased intima-media thickness (Yamada et al, 2005) and pulse wave velocity in Japanese subjects (Tanaka et al, 2006;Okabe et al, 2004). Furthermore, we have shown that the rate of reduction of BMD is an independent predictor of all-cause mortality in male hemodialysis patients and that the presence of vertebral fracture predicts mortality in female hemodialysis patients .…”