Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma

Abstract

Characterization of histologic pattern provides valuable information in the management of uterine carcinosarcoma.

Prognostic Significance of omental Disease and the Role of Omental Sampling in Patients With Uterine Carcinosarcoma

“…In this study, they also confirmed that age, race, stage, residual disease, adjuvant chemotherapy, and adjuvant chemoradiation improved OS. 12 A multi-institution cohort study by Cantrell et al 18 also showed an improvement in PFS in patients with stage IYII UCS receiving adjuvant chemotherapy. The data are more conflicting regarding survival benefit for adjuvant radiation, with a general consensus that it enhances local control but does not improve survival.…”

“…Although retrospective in nature, several studies have demonstrated a benefit to optimal cytoreduction in UCS. 12,16 Beyond removal of bulky disease, a retrospective analysis of the Surveillance, Epidemiology, and End Results Program database by Nemani et al 17 revealed that the 5-year OS was improved for patients undergoing lymphadenectomy compared with those who did not. 17 Each of these results demonstrates a role of surgical intervention in UCS and assists with guiding timing and surgical aggressiveness.…”

“…To put this sample cohort size in perspective, Matsuo et al performed a retrospective review to evaluate the impact of histology on survival in UCS and noted that similar studies comprised median cohort sizes of 44 patients. 12 In addition to a relatively large sample size, all pathology was reviewed and verified by a pathologist trained in the evaluation of gynecologic malignancies. For a retrospective study, clinical and demographic information was complete and relatively exhaustive, which allowed us to control for confounding.…”

“…11,12 A retrospective review of 94 patients with UCS noted omental involvement in 14 (17.7%) of 79 patients undergoing staging. In this study stage, para-aortic lymph node involvement, uterine serosal spread, positive peritoneal cytology, and extrapelvic disease were associated with diseasefree and overall survival (OS); however, only age was associated with disease-free survival on multivariable analysis.…”

Fascin Is Associated With Aggressive Behavior and Poor Outcome in Uterine Carcinosarcoma

“…Selected information from this cohort, including patient demographics and tumor morphology, were also included in a previously published study. 29 Carcinoma occupied the majority of the primary tumor (ie, carcinoma-dominant) in 27 cases (62.8%). The type of carcinoma was roughly distributed into thirds, with serous (n = 16, 36.4%) being slightly more common than mixed (n = 14, 31.8%) and endometrioid carcinoma (n = 12, 27.3 %).…”