Fascin Is Associated With Aggressive Behavior and Poor Outcome in Uterine Carcinosarcoma

Richmond, Abby M.; Blake, Erin A.; Torkko, Kathleen C.; Smith, Elizabeth E.; Spillman, Monique A.; Post, Miriam D.

doi:10.1097/igc.0000000000001077

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…Nestin expression is observed in various embryonic cells and tissues, and a correlation of Nestin expression to clinical malignancy has been reported in melanoma and other tumors, such as breast cancer, ovarian cancer, and osteosarcoma [ 13 , 14 , 18 , 21 , 22 ]. Fascin, an actin-bundling protein, plays an important role in the regulation of cell adhesion, migration and invasion [ 23 , 24 , 25 , 26 , 27 ]. Fascin also exists in different tissues of the human body, such as mesenchyme and nervous tissue, however, it is not present in most normal epithelia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Clinical and Immunohistochemical Factors Relating to Melanoma Metastasis: Potential Roles of Nestin and Fascin in Melanoma

et al. 2022

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For melanoma treatment, an early diagnosis and a complete resection of the primary tumor is essential. In addition, detection of factors that may be related to metastasis is indispensable. A total of 30 Japanese patients with Stage I or II melanoma, diagnosed according to the classification of the American Joint Committee on Cancer, are included in this study. Clinical background (sex, onset age, primary tumor area, existence of remaining cancer cells at the resected tissue margin, and treatment after the primary surgery) and immunohistochemical staining (Nestin and Fascin) on the resected tissue were examined to detect factors statistically related to metastasis. The analysis result has shown that older onset age and positive immunohistochemical expressions of Nestin and Fascin are statistically related to metastasis. To facilitate meticulous observation of Nestin and Fascin expression at different timing (e.g., onset and metastasis), double immunofluorescence staining was performed. Nestin is a class VI intermediate filament protein, initially detected in neural stem cells. Fascin is an actin-bundling protein which regulates cell adhesion, migration and invasion. Nestin and Fascin are suggested to relate to melanoma metastasis, however, the potential role of Fascin is controversial. Analysis of variations in Fascin expression detected in this study may contribute to further investigations concerning potential roles of Fascin for progression of melanoma. This is the first study to report double immunofluorescent staining of Nestin and Fascin in melanoma. Nestin and Fascin double-positive melanoma cells were detected.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Clinical and Immunohistochemical Factors Relating to Melanoma Metastasis: Potential Roles of Nestin and Fascin in Melanoma

et al. 2022

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“…Here, an additional factor potentially related to recurrence has been added, specifically, Fascin-1 immunostaining. Fascin-1, an actin-bundling protein, plays an important role in the regulation of cell adhesion, migration, and invasion (27)(28)(29)35). Fascin-1 widely exists in different tissues of the human body, such as mesenchyme and nervous tissue, however it is not present in most normal epithelia.…”

Section: Discussionmentioning

confidence: 99%

“…However, after 2019, Arlt et al reported Fascin-1 expression also correlates with progression and metastasis in osteosarcoma and chondrosarcoma ( 29 ). Additionally, Richmond et al reported that Fascin-1 is a mediator of invasion in uterine carcinosarcoma as a component of epithelial-mesenchymal transition ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma

et al. 2021

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Fascin-1, an actin-bundling protein, is associated with poor prognosis in patients with various types of human carcinoma. However, research is limited on the role of fascin-1 in sarcoma. Solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare sarcomas derived from the mesenchyme. Although the prognosis of SFT/HPC is generally favorable, fatalities are possible with repeated recurrence and distant metastasis. The current study included a total of 20 Japanese patients, who were diagnosed with SFT/HPC and underwent surgery at Kochi University Hospital from January 2000 to December 2019. The statistical relationship between recurrence and the following variables were examined: Sex, age of onset, tumor origin, tumor size, necrosis, mitosis ≥1/10 high power field (HPF; magnification, x400), Ki-67 >5% and Fascin-1. A significant association was determined between recurrence and necrosis, mitosis ≥1/10 HPF (magnification, x400), Ki-67 >5%, and Fascin-1 ≥'strongly positive' (P<0.05). The results demonstrated that Fascin-1 immunostaining may be a highly effective and useful evaluation factor for predicting poor prognosis in patients with SFT/HPC, a fatal sarcoma of humans.

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“…Numerous studies have reported overexpression of FSCN1 in various gynecological cancers [ 123 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 ] as indicated in Table 1 .…”

Section: Fascin In Gynecological Cancersmentioning

confidence: 99%

“…Uterine carcinosarcoma cases were assessed for FSCN1 expression using IHC; while FSCN1 was absent in benign cases, it was present in both malignant epithelial and mesenchymal elements of uterine carcinosarcomas. This finding was associated with a more aggressive phenotype (advanced stage and large tumor size) and a poor outcome [ 142 ]. Additionally, FSCN1 was found to be a potential IHC biomarker in differentiating uterine leiomyosarcoma from leiomyoma [ 135 ].…”

Section: Fascin In Gynecological Cancersmentioning

confidence: 99%

Fascin in Gynecological Cancers: An Update of the Literature

Gupta

Vranić

Al-Thawadi

et al. 2021

Cancers

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Fascin is an actin-binding protein that is encoded by the FSCN1 gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different types of human cancers in which its expression correlated with tumor growth, migration, invasion, and metastasis. Moreover, overexpression of fascin was found in oncovirus-infected cells, such as human papillomaviruses (HPVs) and Epstein-Barr virus (EBV), disrupting the cell–cell adhesion and enhancing cancer progression. Based on these findings, several studies reported fascin as a potential biomarker and a therapeutic target in various cancers. This review provides a brief overview of the FSCN1 role in various cancers with emphasis on gynecological malignancies. We also discuss fascin interactions with other genes and oncoviruses through which it might induce cancer development and progression.

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Fascin Is Associated With Aggressive Behavior and Poor Outcome in Uterine Carcinosarcoma

Abstract: Fascin is aberrantly expressed in both elements of UCS and is associated with aggressive behavior and worse outcome. As a component of EMT and mediator of invasion, fascin may serve as a target in future therapies.

Cited by 10 publications

References 40 publications

Evaluation of Clinical and Immunohistochemical Factors Relating to Melanoma Metastasis: Potential Roles of Nestin and Fascin in Melanoma

Evaluation of Clinical and Immunohistochemical Factors Relating to Melanoma Metastasis: Potential Roles of Nestin and Fascin in Melanoma

Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma

Fascin in Gynecological Cancers: An Update of the Literature

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