“…Utilising all the available information, such as mechanistic studies, empirical methods, hazard data, and computational toxicity models, as well as environmental chemistry and toxicology, chemists can prioritise safety from the beginning of the process. 4,18 Moreover, the Environmental Assessment Tool for Organic Synthesis (EATOS) metric has been developed, which quantifies not only the reactants and waste but also their relative toxicity effects. 4,54 Another important topic of this Principle is the transformation of waste into energy, fuels, and other reusable materials, always considering the reduction of the impacts on human health and the environment.…”