GreenMedChem: the challenge in the next decade toward eco-friendly compounds and processes in drug design

Abstract

Green Chemistry has become a hot topic on which not only many companies but also researchers have focused their attention. Green Chemistry strives to identify alternative and environmentally friendly reaction...

Harnessing the 12 Green Chemistry Principles for Sustainable Antiparasitic Drugs: Toward the One Health Approach

“…57 The authors noted that their approach facilitated continuous synthesis of 19 at a scale of 10 g/h, which is sufficient to treat 4800 patients per day. 57 Wu et al redescribed the synthesis of the antimalarial drug pyrimethamine (20) following an innovative mechanochemical protocol (Figure 3d). 58 Pyrimethamine is a drug active against the erythrocytic stages of all Plasmodium species by inhibiting plasmodial dihydrofolate reductase (DHFR), thus blocking the biosynthesis of purines and pyrimidines.…”

“…To make a step further toward One Health, we believe that the emerging green and sustainable practices in medicinal chemistry − are a great opportunity for developing new drugs for animal and human VBPDs, produced by alternative and environmentally friendly methods. In other words, we want to use chemistry for curing both animals and humans but not at the expense of the environment.…”

HAuCl4 Catalyzed and Dibenzyl amine Centered A3 coupling reaction: Synthesis, Spectroscopic Proofing and Anti‐microbial Efficacy

“…Chemists are now increasingly lean towards “green chemistry” due to rising environmental awareness. Consequently, heterogeneous catalysts that may be recovered can play a role in the prevention or minimization of chemical wastes, especially in the context of large‐scale and industrial processes [22] . This study focuses on the synthesis of A 3 adducts of amines, aldehydes, and alkynes in relation to the described issues and as a continuation of our research in the green chemistry domain [23–26] .…”

“…Consequently, heterogeneous catalysts that may be recovered can play a role in the prevention or minimization of chemical wastes, especially in the context of large-scale and industrial processes. [22] This study focuses on the synthesis of A 3 adducts of amines, aldehydes, and alkynes in relation to the described issues and as a continuation of our research in the green chemistry domain. [23][24][25][26] By including DBA as one of the colliding species, the Au salt acts as a catalyst to speed up the synthesis process proposed.…”

Lavandula pedunculata Polyphenol-Rich Extracts Obtained by Conventional, MAE and UAE Methods: Exploring the Bioactive Potential and Safety for Use a Medicine Plant as Food and Nutraceutical Ingredient

“…However, there is a pressing need to decrease the usage of organic solvents and improve the energy efficiency of procedures used to extract bioactive compounds (BCs) from plants or foods [9]. Therefore, green chemistry-based extraction methods emerge as a possible alternative to the CE method with organic solvents, given their advantageous attributes, namely decreasing or eliminating hazardous solvents and limiting the cost of solvent waste disposal [10]. Moreover, it allows safety extracts to be obtained that could be used in the food, pharmaceutical and cosmetic industries.…”