Significance of glycated LDL in different stages of diabetic nephropathy

Siddiqui, Khalid; George, Teena P.; Nawaz, Shaik Sarfaraz; Yaslam, Maram; Almogbel, Ebtehal; Al‐Rubeaan, Khalid

doi:10.1016/j.dsx.2018.11.023

Cited by 10 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, increased glycated apoB was associated with an approximately two-times-higher risk of myocardial infarction in elderly diabetic and non-diabetic subjects [ 77 ]. The results of Cohen et al [ 75 ] showed a gradual increase of glycated LDL particles’ concentration in parallel with rise of albumin excretion rate, while Siddiqui and colleagues [ 78 ] found elevated glycated LDLs in patients with diabetic nephropathy. These findings suggest that glycated LDL particles might also be implicated in the development of microvascular complications of DM, although the available data are limited.…”

Section: The Role Of Glycated Ldl: Relationships With Inflammationmentioning

confidence: 99%

“…However, unlike sdLDL and oxidized LDL, the clinical importance of glycated LDLs’ determination is less certain. One potential explanation is the fact that, so far, a wide variety of commercially available or in-house developed assays were employed to assess the extent of LDL glycation across the studies [ 75 , 78 , 95 , 96 ]. Since these tests examined different properties of glycated LDLs, the terminology used across the studies is heterogeneous, thus limiting the generalization of the results and requiring harmonization ( Figure 3 ).…”

Section: Implications For Cardiovascular Prevention and Future Direct...mentioning

confidence: 99%

See 1 more Smart Citation

The Role of Advanced Glycation End Products on Dyslipidemia

et al. 2023

View full text Add to dashboard Cite

Disorders of lipoprotein metabolism and glucose homeostasis are common consequences of insulin resistance and usually co-segregate in patients with metabolic syndrome and type 2 diabetes mellitus (DM). Insulin-resistant subjects are characterized by atherogenic dyslipidemia, a specific lipid pattern which includes hypertriglyceridemia, reduced high-density lipoprotein cholesterol level, and increased proportion of small, dense low-density lipoprotein (LDL). Chronic hyperglycemia favors the processes of non-enzymatic glycation, leading to the increased production of advanced glycation end products (AGEs). Apart from direct harmful effects, AGEs are also potent inducers of oxidative stress and inflammation. In addition, increased AGEs’ production may induce further qualitative modifications of small, dense LDL particles, converting them to glycated LDLs. These particles are even more atherogenic and may confer an increased cardiovascular risk. In this narrative review, we summarize the available evidence of the pathophysiological role and clinical importance of circulating AGEs and glycated LDLs in patients with dyslipidemia, particularly those with DM and related complications. In addition, we discuss recent advances and the issues that should be improved regarding laboratory assessment of AGEs and glycated LDLs, as well as the possibilities for their therapeutic modulation.

show abstract

Section: The Role Of Glycated Ldl: Relationships With Inflammationmentioning

confidence: 99%

Section: Implications For Cardiovascular Prevention and Future Direct...mentioning

confidence: 99%

The Role of Advanced Glycation End Products on Dyslipidemia

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Elevated levels of Advanced Glycosylation End-products (AGE) on LDL are manifested in diabetic conditions than in normal individuals and is governed by glucose concentration as well as duration of exposure ( Goh and Cooper, 2008 ). Furthermore, glycated LDL is prone to oxidation and thus gLDL or highly oxidized gLDL (HOGL) increases the susceptibility to atherogenesis ( Siddiqui et al, 2019 ). The spontaneous carbamylation of amine residues on LDL ApoB by urea- or thiocyanate-derived cyanate generates cLDL ( Kraus and Kraus, 2001 ).…”

Section: Lipid Metabolism and Associated Diseasesmentioning

confidence: 99%

Pathological Crosstalk Between Oxidized LDL and ER Stress in Human Diseases: A Comprehensive Review

Varghese

Ali

2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

The oxidative modification of the major cholesterol carrying lipoprotein, oxLDL, is a biomarker as well as a pathological factor in cardiovascular diseases (CVD), type 2 diabetes mellitus (T2DM), obesity and other metabolic diseases. Perturbed cellular homeostasis due to physiological, pathological and pharmacological factors hinder the proper functioning of the endoplasmic reticulum (ER), which is the major hub for protein folding and processing, lipid biosynthesis and calcium storage, thereby leading to ER stress. The cellular response to ER stress is marked by a defensive mechanism called unfolded protein response (UPR), wherein the cell adapts strategies that favor survival. Under conditions of excessive ER stress, when the survival mechanisms fail to restore balance, UPR switches to apoptosis and eliminates the defective cells. ER stress is a major hallmark in metabolic syndromes such as diabetes, non-alcoholic fatty liver disease (NAFLD), neurological and cardiovascular diseases. Though the pathological link between oxLDL and ER stress in cardiovascular diseases is well-documented, its involvement in other diseases is still largely unexplored. This review provides a deep insight into the common mechanisms in the pathogenicity of diseases involving oxLDL and ER stress as key players. In addition, the potential therapeutic intervention of the targets implicated in the pathogenic processes are also explored.

show abstract

“…2 Many studies have found evidence that hyperglycemia and persistent diabetes duration lead to chronic metabolic and hemodynamic changes that modulate various intracellular signaling pathways, transcription factors, cytokines, and chemokines. 3,4 The growing consequences of these changes promote abnormal features such as glomerular basement membrane thickening, mesangial matrix expansion, podocyte injury, glomerular sclerosis, and tubulointerstitial fibrosis. [4][5][6] Thyroid hormone has been reported to exert both pre-renal and direct renal effects causing renal blood flow, glomerular filtration rate, and renal tubular functions.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 The growing consequences of these changes promote abnormal features such as glomerular basement membrane thickening, mesangial matrix expansion, podocyte injury, glomerular sclerosis, and tubulointerstitial fibrosis. [4][5][6] Thyroid hormone has been reported to exert both pre-renal and direct renal effects causing renal blood flow, glomerular filtration rate, and renal tubular functions. 7 Clinical effects of hypothyroidism are associated with increased serum creatinine, decreased serum cystatin C, and an increase in 24-h urine protein.…”

Section: Introductionmentioning

confidence: 99%

Low Circulating Free Triiodothyronine Levels are Associated with the Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes

Siddiqui¹,

Nawaz²,

Alfadda³

et al. 2022

IJGM

Self Cite

View full text Add to dashboard Cite

Background: Diabetic Nephropathy (DN) is one of the most typical causes of end-stage renal disease and thyroid hormone exerts effects on the kidney. There are few reports on the role of thyroid hormone in the progression of DN. We aimed to assess the relationship between thyroid hormone and DN. Methods: In this cross-sectional study, 400 patients with type 2 diabetes (T2D) (aged between 35 and 70 years) were divided into two groups T2D control and DN group according to albumin creatinine ratio (ACR). Clinical biochemistry parameters were measured using the Rx Daytona chemistry analyzer and thyroid hormone levels (TT4, TT3, TSH, FT4, and FT3) using the Evidence Biochip analyzer. To assess the relationship between thyroid hormone and DN, multiple logistic regression models were developed. Results: Serum FT4 and FT3 levels were significantly lower in DN compared to T2D controls (p<0.05). Thyroid hormone levels tend to decrease with the progression of DN. In unadjusted and adjusted logistic regression models, FT3 levels were negatively associated with odds of having DN (OR=0.28, CI=0.128-0.616, p=0.002). Conclusion:The free triiodothyronine level was negatively associated with the progression of DN. Further longitudinal studies are required to assess the cause of thyroid hormone differences.

show abstract

Significance of glycated LDL in different stages of diabetic nephropathy

Cited by 10 publications

References 12 publications

The Role of Advanced Glycation End Products on Dyslipidemia

The Role of Advanced Glycation End Products on Dyslipidemia

Pathological Crosstalk Between Oxidized LDL and ER Stress in Human Diseases: A Comprehensive Review

Low Circulating Free Triiodothyronine Levels are Associated with the Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes

Contact Info

Product

Resources

About