Significance of Endogenous Antimicrobial Peptides on the Health of Food Animals

Fasina, Y. O.; Obanla, Temitayo; Dosu, George; Muzquiz, Sierra

doi:10.3389/fvets.2021.585266

Cited by 8 publications

(10 citation statements)

References 81 publications

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“…In this context, AMPs have gained relevance due to their broadspectrum antimicrobial activity. [37][38][39] Fishes, in particular, have been identified as a rich source of these short peptides, documented for their antimicrobial and immunomodulatory activities. 7 In the present study, we investigated for the first time the antiviral effect of a fish F I G U R E 6 Antiviral activity of oreoch-1 against SBV infection.…”

Section: Discussionmentioning

confidence: 99%

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Oreoch‐1: A broad‐spectrum virus and host‐targeting peptide against animal infections

Nastri,

Chianese,

Giugliano

et al. 2024

Journal of Peptide Science

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In recent decades, the global rise of viral emerging infectious diseases has posed a substantial threat to both human and animal health worldwide. The rapid spread and accumulation of mutations into viruses, and the limited availability of antiviral drugs and vaccines, stress the urgent need for alternative therapeutic strategies. Antimicrobial peptides (AMPs) derived from natural sources present a promising avenue due to their specificity and effectiveness against a broad spectrum of pathogens. The present study focuses on investigating the antiviral potential of oreochromicin‐1 (oreoch‐1), a fish‐derived AMP obtained from Nile tilapia, against a wide panel of animal viruses including canine distemper virus (CDV), Schmallenberg virus (SBV), caprine herpesvirus 1 (CpHV‐1), and bovine herpesvirus 1 (BoHV‐1). Oreoch‐1 exhibited a strong antiviral effect, demonstrating an inhibition of infection at concentrations in the micromolar range. The mechanism of action involves the interference with viral entry into host cells and a direct interaction between oreoch‐1 and the viral envelope. In addition, we observed that the peptide could also interact with the cell during the CDV infection. These findings not only highlight the efficacy of oreoch‐1 in inhibiting viral infection but also emphasize the potential of fish‐derived peptides, specifically oreoch‐1, as effective antiviral agents against viral infections affecting animals, whose potential to spill into humans is high. This research contributes valuable insights to the ongoing quest for novel antiviral drugs with the potential to mitigate the impact of infectious diseases on a global scale.

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Section: Discussionmentioning

confidence: 99%

“…In this context, AMPs have gained relevance due to their broad‐spectrum antimicrobial activity 37–39 . Fishes, in particular, have been identified as a rich source of these short peptides, documented for their antimicrobial and immunomodulatory activities 7 .…”

Section: Discussionmentioning

confidence: 99%

Oreoch‐1: A broad‐spectrum virus and host‐targeting peptide against animal infections

Nastri,

Chianese,

Giugliano

et al. 2024

Journal of Peptide Science

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“…Antimicrobial peptides (AMPs) are known as promising antibiotic alternatives because of their strong specificity and high molecular stability. AMPs are mainly classified based on the structural composition and amino acid sequence, including defensins, cathelicidins, hepcidins, histone-derived peptides, and fish specific piscidins (Fasina et al, 2021). Proline-Arginine-39 (PR-39) is a small cationic cathelicidin that has antibacterial activity against Enterococcus faecalis, E. coli, and Bacillus subtilis and relieve intestinal inflammation and diarrhea in pigs (Holani et al, 2016).…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Emergence and spread of antibiotic-resistant foodborne pathogens from farm to table

Kim

Ahn

2022

Food Sci Biotechnol

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Antibiotics have been overused and misused for preventive and therapeutic purposes. Specifically, antibiotics are frequently used as growth promoters for improving productivity and performance of food-producing animals such as pigs, cattle, and poultry. The increasing use of antibiotics has been of great concern worldwide due to the emergence of antibiotic resistant bacteria. Food-producing animals are considered reservoirs for antibiotic resistance genes (ARGs) and residual antibiotics that transfer from the farm through the table. The accumulation of residual antibiotics can lead to additional antibiotic resistance in bacteria. Therefore, this review evaluates the risk of carriage and spread of antibiotic resistance through food chain and the potential impact of antibiotic use in food-producing animals on food safety. This review also includes in-depth discussion of promising antibiotic alternatives such as vaccines, immune modulators, phytochemicals, antimicrobial peptides, probiotics, and bacteriophages.

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“…To prevent the onset of infectious diseases in poultry, sanitation of the rearing facilities, vaccination for prevention, and medication are used, but these measures are costly and labor intensive. Research is being conducted on the use of endogenous AMPs to protect poultry from infection [ 7 ]. In chickens ( Gallus gallus ), the presence of four AMPs belonging to the CATH family has been reported in the bursa of Fabricius (BF), and they were named fowlicidin-1, -2, and -3 and CATH-B1 [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Cloning, Expression Analyses, and Physiological Roles of Cathelicidins in the Bursa of Fabricius of the Japanese Quail, Coturnix japonica

Ikeda,

Kondo,

Nunomura

et al. 2023

Antibiotics

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Antimicrobial peptides (AMPs) act directly on pathogens and maintain the anti-inflammatory effects and activation of immunocompetent cells. Therefore, the activation of the immune system in poultry via the elevation of endogenous AMPs has been attempted. In this study, we focused on the host defense mechanisms in the bursa of Fabricius (BF) of Japanese quail, cloned the cDNA of cathelicidin (CATH)-1 to -3, and analyzed their expression sites. In situ hybridization experiments revealed the mRNA expression of the CATHs in the interfollicular epithelium surrounding the lumen of the quail BF, which suggests that each CATH may exert its antimicrobial action directly in the BF. The intravenous injection of bacterial lipoteichoic acid and lipopolysaccharide endotoxins into the quail promoted the mRNA expression of CATH-1 and CATH-3 in the BF. The addition of CATH-1 or CATH-2 at the time of the antigen injection into mice resulted in antiserum with high antibody titers. Ad libitum administration of butyrate, a short-chain fatty acid, in the drinking water induced an increase in CATH-2 mRNA expression in the BF under certain conditions. These results may improve the defense mechanisms of quail by stimulating CATH expression in the BF through their diet.

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Significance of Endogenous Antimicrobial Peptides on the Health of Food Animals

Cited by 8 publications

References 81 publications

Oreoch‐1: A broad‐spectrum virus and host‐targeting peptide against animal infections

Oreoch‐1: A broad‐spectrum virus and host‐targeting peptide against animal infections

Emergence and spread of antibiotic-resistant foodborne pathogens from farm to table

Molecular Cloning, Expression Analyses, and Physiological Roles of Cathelicidins in the Bursa of Fabricius of the Japanese Quail, Coturnix japonica

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