Emergence and spread of antibiotic-resistant foodborne pathogens from farm to table

Kim, Junhwan; Ahn, Juhee

doi:10.1007/s10068-022-01157-1

Cited by 49 publications

(30 citation statements)

References 217 publications

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“…Owing to antibiotic overuse in the medical, fishery, and livestock and poultry breeding industry, several antibioticresistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Streptococcus pneumoniae (MDRSP), and vancomycin-resistant Enterococcus (VRE) have emerged, posing new challenges to food hygiene and safety and efficacy of medicines (Gomes et al, 2022;Kim & Ahn, 2022;Le et al, 2022). To overcome the challenges posed by the increasing emergence of drug-resistant bacteria and their strong environmental adaptability, researchers are using a combination of antibiotics to treat bacterial infections (Beardmore et al, 2017;Li et al, 2022b;Pabon et al, 2022).…”

Section: The Challenge Of Antibiotic-resistant Microorganismsmentioning

confidence: 99%

Antimicrobial activity of oridonin

Zhou

2023

Food Sci. Technol

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Oridonin is an enantiomer-kaurene tetracyclic diterpenoid compound, which is the main active component of Rabdosia rubescens, a herb used in traditional Chinese medicine. It has been reported to exert anti-tumor, anti-inflammatory, proapoptotic, anti-angiogenic, neuroprotective, and other pharmacological effects. Owing to the overuse of antibiotics, currently, the medical and food industries are facing drug resistance challenges, which have severely impacted food and medical safety. Thus, new antibacterial agents must be identified. As an important active component of Rabdosia rubescens, oridonin has been extensively and deeply studied in antimicrobial aspects. This paper reviews the antimicrobial activity of oridonin and its underlying mechanism. In addition, its safety and application as an antibacterial agent were briefly introduced. Finally, the current problems and challenges of the application of oridonin and the prospects were also elucidated.

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Section: The Challenge Of Antibiotic-resistant Microorganismsmentioning

confidence: 99%

Antimicrobial activity of oridonin

Zhou

2023

Food Sci. Technol

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“…These problems are exacerbated in extreme conditions [11]. The problem of the spreading of antibiotic resistance is also to some extent related to food safety [12][13][14][15][16]. However, the key issue of food safety has been and remains the fight against foodborne pathogens [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Biofilm formation and auto-aggregation abilities of novel targeted aqua-probiotics

Մանվելյան¹,

Բալայան²,

Miralimova³

et al. 2023

FFHD

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Background: The probiotics’ auto-aggregation and biofilm formation abilities have a significant role in the development of biotechnological processes.Objective: The aim of this study was to evaluate the biofilm formation and auto-aggregation abilities of novel, targeted aqua-probiotics isolated from aquatic organisms.Methods: The biofilm formation abilities of Lactobacillus delbrueckii str. UZ-1, Lactiplantibacillus plantarum str. R3, Lactococcus str. UZ-2, Enterococcus faecium str. R2, Pediococcus acidilactici str. N from the culture collection of the Microbiology of the Academy of Sciences of the Republic of Uzbekistan, Bacillus subtilis str. 1R, Bacillus amyloliquefaciens str. 4R and from the culture collection of the Southern Federal University of Russa and Lacticaseibacillus rhamnosus str. 1A and Enterococcus str. 9-3 from the culture collection of the Armenian National Agrarian University were assessed.Results: According to the investigations, the biofilm formation abilities of Lactobacillus delbrueckii str. UZ-1, Lactiplantibacillus plantarum str. R3, Lactococcus str. UZ-2, Enterococcus faecium str. R2, Pediococcus acidilactici str. N, Bacillus subtilis str. 1R, Bacillus amyloliquefaciens str. 4R, Bacillus amyloliquefaciens str. 5R, Lacticaseibacillus rhamnosus str. 1A and Enterococcus str. 9-3 were 0.119 ± 0.05D, 0.113 ± 0.065D, 0.196 ± 0.04D, 0.116 ± 0.01D, 0.152 ± 0.05D, 0.74 ± 0.15D, 2.621± 0.55D, 1.831 ± 0.45D, and 0.227 ± 0.04D and 0.483 ± 0.15D respectively. The highest rate of auto-aggregation was shown by Bacillus amyloliquefaciens str. 5R, and Bacillus amyloliquefaciens str. 4R was the strain with the highest ability to form biofilm. These two Bacillus strains are also distinguished by the highest DNA protective properties and relatively low antioxidant activity. Despite the fact that Bacillus amyloliquefaciens str. 5R showed the highest rate of auto-aggregation after 2 hours, this strain showed the lowest level of auto-aggregation among the studied strains after 24 hours. The Enterococcus str. 9-3 strain with the highest antioxidant activity showed 0.483 ± 0.15D biofilm formation ability.Conclusion: The novel targeted aquaprobiotics have distinct biofilm formation and aggregation properties, which are important to consider when planning appropriate biotechnological processes, requiring specific membrane properties of probiotics.Graphical Abstract: Membrane properties of novel targeted aquaprobiotics.Keywords: Lactobacilli, aqua-probiotic, antioxidant activity, biofilm formation, aggregation, Enterococcus str. 9-3

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“…This has become a global health concern worldwide (Donado-Godoy et al ., 2015). The emergence of resistance to antibiotics in microorganisms, especially bacteria, is partially due to the existence of resistance genes (Zalewska et al ., 2021), and farm animals, such as cattle being the prime reservoirs for these genes (Kim and Ahn, 2022).…”

Section: Introductionmentioning

confidence: 99%

Investigating Antimicrobial Resistance Genes in Kenya, Uganda and Tanzania Cattle Using Metagenomics

Omar,

Kitundu,

Jimoh

et al. 2023

Preprint

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Antimicrobial resistance (AMR) is a growing problem in African cattle production systems, posing a threat to human and animal health and the associated economic value chain. However, there is a poor understanding of the resistomes in small-holder cattle breeds in East African countries. This study aims to examine the distribution of Antimicrobial Resistance Genes (ARGs) in Kenya, Tanzania, and Uganda cattle using a metagenomics approach.We used the SqueezeMeta-Abricate (assembly-based) pipeline to detect ARGs and benchmarked this approach using the Centifuge-AMRplusplus (read-based) pipeline to evaluate its efficiency. Our findings reveal a significant number of ARGs of critical medical and economic importance in all three countries, including resistance to drugs of last resort such as carbapenems, suggesting the presence of highly virulent and antibiotic-resistant bacterial pathogens (ESKAPE) circulating in East Africa.Shared ARGs such as aph(6)-id (aminoglycoside phosphotransferase), tet (tetracycline resistance gene), sul2 (sulfonamide resistance gene) and cfxA_gen (betalactamase gene) were detected. Assembly-based methods revealed fewer ARGs compared to read-based methods, indicating the sensitivity and specificity of read-based methods in resistome characterization.Our findings call for further surveillance to estimate the intensity of the antibiotic resistance problem and wider resistome classification. Effective management of livestock and antibiotic consumption is crucial in minimizing antimicrobial resistance and maximizing productivity, making these findings relevant to stakeholders, agriculturists, and veterinarians in East Africa and Africa at large.

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Emergence and spread of antibiotic-resistant foodborne pathogens from farm to table

Cited by 49 publications

References 217 publications

Antimicrobial activity of oridonin

Antimicrobial activity of oridonin

Biofilm formation and auto-aggregation abilities of novel targeted aqua-probiotics

Investigating Antimicrobial Resistance Genes in Kenya, Uganda and Tanzania Cattle Using Metagenomics

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