Significance of cytosolic hyaluronan levels in gastric cancer

Vizoso, F; Casar, José M. del; Corte, M.D.; García, I; Corte, M.G.; Alvarez, A. M.; García-Muñiz, José L.

doi:10.1016/j.ejso.2003.11.007

Cited by 21 publications

(12 citation statements)

References 23 publications

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“…In the present study we have evaluated the potential relationship between LBVI and several new biological parameters from gastric carcinomas recently associated with tumoral aggressiveness and poor prognosis, such as the tyrosine kinase receptors c-erbB-2 (Garcia et al 2003a;Vizoso et al 2004b) and EGFR (Garcia et al 2003b), the proteolytic enzymes cathepsin D (Manuel Del Casar et al 2004) and tPA (Raigoso et al 2000), the spasmolytic peptide pS2 (Suarez et al 2001;Dhar et al 2003) or the extracellular proteoglycan hyaluronic acid (Vizoso et al. 2004a).…”

Section: Discussionmentioning

confidence: 99%

Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance

Casar

Corte

Alvarez

et al. 2007

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 99%

Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance

Casar

Corte

Alvarez

et al. 2007

J Cancer Res Clin Oncol

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“…Thus, immunohistochemical studies have demonstrated that the expression of HA by tumor cells correlated with a shorter overall survival period in ovarian [24], gastric [8] carcinomas. Likewise, we have proven that high cytosolic tumor HA levels, determined by immunoradiometric assay (IRMA), were significantly associated with an unfavorable outcome in patients with either resectable colorectal cancer [25] or resectable gastric cancer [26]. Relevant information on the clinical significance of HA in breast cancer is scarce.…”

Section: Introductionmentioning

confidence: 98%

Expression and Clinical Signification of Cytosolic Hyaluronan Levels in Invasive Breast Cancer

Corte

González

Lamelas

et al. 2006

Breast Cancer Res Treat

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“…Elevated levels of HA, a major component of the extracellular matrix (ECM), were found to correlate with several types of cancers (Itano and Kimata, 2008), including gastric (Vizoso et al, 2004), prostate (Lokeshwar et al, 2001), endometrial (Paiva et al, 2005), and bladder (Kramer et al, 2010;Lokeshwar et al, 1997Lokeshwar et al, , 1999Pham et al, 1997). In several studies, the level of HA was found to be associated with the degree of severity and spread of the disease through the body (Kramer et al, 2010;Paiva et al, 2005;Pham et al, 1997;Vizoso et al, 2004). Other studies found a link between poor prognosis in prostate cancer and undersulfation in CS (Teng et al, 2008) or elevated levels of CS (Ricciardelli et al, 1997(Ricciardelli et al, , 1999.…”

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confidence: 99%

A Structural Analysis of Glycosaminoglycans from Lethal and Nonlethal Breast Cancer Tissues: Toward a Novel Class of Theragnostics for Personalized Medicine in Oncology?

Weyers

Yang

Yoon

et al. 2012

OMICS: A Journal of Integrative Biology

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Cancer is one of the leading noncommunicable diseases that vastly impacts both developed and developing countries. Truly innovative diagnostics that inform disease susceptibility, prognosis, and/or response to treatment (theragnostics) are seriously needed for global public health and personalized medicine for patients with cancer. This study examined the structure and content of glycosaminoglycans (GAGs) in lethal and nonlethal breast cancer tissues from six patients. The glycosaminoglycan content isolated from tissue containing lethal cancer tumors was approximately twice that of other tissues. Molecular weight analysis showed that glycosaminoglycans from cancerous tissue had a longer weight average chain length by an average of five disaccharide units, an increase of approximately 15%. Dissacharide analysis found differences in sulfation patterns between cancerous and normal tissues, as well as sulfation differences in GAG chains isolated from patients with lethal and nonlethal cancer. Specifically, cancerous tissue showed an increase in sulfation at the ''6S'' position of CS chains and an increase in the levels of the HS disaccharide NSCS. Patients with lethal cancer showed a decrease in HS sulfation, with lower levels of ''6S'' and higher levels of the unsulfated ''0S'' disaccharide. Although these findings come from a limited sample size, they indicate that structural changes in GAGs exist between cancerous and noncancerous tissues and between tissues from patients with highly metastatic cancer and cancer that was successfully treated by chemotherapy. Based on these findings, we hypothesize that (1) there are putative changes in the body's construction of GAGs as tissue becomes cancerous; (2) there may be innate structural person-to-person variations in GAG composition that facilitate the metastasis of tumors in some patients when they develop cancer.

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Significance of cytosolic hyaluronan levels in gastric cancer

Cited by 21 publications

References 23 publications

Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance

Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance

Expression and Clinical Signification of Cytosolic Hyaluronan Levels in Invasive Breast Cancer

A Structural Analysis of Glycosaminoglycans from Lethal and Nonlethal Breast Cancer Tissues: Toward a Novel Class of Theragnostics for Personalized Medicine in Oncology?

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