Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance

Casar, José M. del; Corte, M.D.; Alvarez, A. M.; García, I; Bongera, Miguel; González, Luis O.; García-Muñiz, José L.; Allende, M.T.; Astudillo, Aurora; Vizoso, F

doi:10.1007/s00432-007-0264-3

Cited by 48 publications

(43 citation statements)

References 45 publications

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“…Nevertheless, the trend remained consistent after adjusting for poor prognostic factors such as lymphatic and/or blood vessel invasion (24)(25)(26), perineural invasion (27), stage and treatment.…”

Section: Discussionmentioning

confidence: 79%

Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer

Kolb

Özbek

Harpaz

et al. 2017

J. Gastrointest. Oncol.

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Background:Helicobacter pylori (H pylori) infection is a known risk factor for gastric cancer (GC) and has been linked with gastroesophageal junction (GEJ) cancer. Studies examining the relationship between H.pylori infection, GC characteristics and prognosis are limited and have yielded conflicting results. We report on the clinicopathologic characteristics and oncologic outcomes of gastric and GEJ cancer patients with and without a history of H. pylori treated at our institution. Results: Ninety-five patients were identified. The majority of patients were male (61%), white (36%) or Asian (34%), with median age at diagnosis 64. Tumors were stage I (51%), stage II (23%), stage III (25%), and stage IV (1%). H pylori infection status was documented at the time of cancer diagnosis in 89 (94%) patients, and following cancer diagnosis and treatment in 6 (6%) patients. Younger age at diagnosis, Asian race and Lauren histologic classification were associated with H Pylori infection. H pylori positive patients exhibited higher 5-year OS and 5-year RFS compared to H pylori negative patients, though the difference was not statistically significant in either univariate or multivariate analyses. Conclusions:In this retrospective series of predominantly early stage GC and GEJ cancers, H. pylori positive patients were significantly younger at cancer diagnosis and were more frequently Asian compared to H. pylori negative patients. Other demographic and histologic classifications except for Lauren histologic classification were similar between the two groups. H pylori positive patients appeared to have improved outcomes compared to H. pylori negative patients.

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Section: Discussionmentioning

confidence: 79%

Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer

Kolb

Özbek

Harpaz

et al. 2017

J. Gastrointest. Oncol.

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“…Poor prognosis of gastric cancer patients occurs due to rapid metastasis of the disease via the lymphs as well as blood in advanced stages. Previous studies have shown that lymphatic and blood vessel invasion (LBVI) is closely correlated with characteristics of gastric cancer patients, including tumor stage, lymph node metastasis and histological type, which may be used as the indices to determine the metastasis and prognosis of gastric cancer patients (del Casar et al, 2008;Kim et al, 2010;Du et al, 2012). The antibodies D2-40 and CD34 are characterized as specificity labels of the endothelial cells of the lymphatic and blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Lymphangiogenic and Angiogenic Microvessel Density in Chinese Patients with Gastric Carcinoma: Correlation with Clinicopathologic Parameters and Prognosis

Cao

Hu²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The incidence of gastric cancer worldwide, and in particular in developing countries, has shown a marked increase. Poor prognosis of gastric cancer patients occurs due to the rapid metastasis of the disease via the lymphatic and blood vessels. The aim of this study was to investigate the expression and the clinical significance of D2-40 and CD34 in human gastric cancer. D2-40 and CD34 expression wasdetected in 1,072 cases of Chinese patients with gastric carcinoma using immunohistochemistry. The lymphatic vessel density (LVD) and microvessel density (MVD) were calculated and analyzed and the correlation with the clinicopathological factors and prognosis was determined. The LVD and MVD of the gastric cancer cases were significantly higher compared to those of normal tissues (P < 0.05). The expression of D2-40-LVD and CD34-MVD in the malignancies were positively related to the age, tumor size, invasion depth, lymphatic metastasis and pathological tumor-node-metastasis (pTNM) (P < 0.05); However, no statistically significant difference was identified between them with the patient gender (P > 0.05). Up-regulation of D2-40 and CD34 expression was significantly correlated with the poor survival rate in univariate and multivariate analyses. The LVD marked by D2-40 and the MVD marked by CD34 were positively correlated to the clinicopathological factors of the malignancies and may play important role in the development and progression of gastric cancer.

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“…In addition, statistical analysis demonstrated that LBVI was significantly associated with a poorer overall patients' survival in the univariate analysis as well as in the multivariate analysis. However, their results failed to show any significant relationship between LBVI and any of the intratumoral biological parameters studies [22].…”

Section: Lymphatic and Vascular Invasionmentioning

confidence: 83%

Prognosis in the Cancer of the Stomach

Akturk¹,

Ulusoy²

2013

Gastric Carcinoma- New Insights Into Current Management

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Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance

Abstract: LBVI provides additional useful information that could be applied to identify gastric cancer patients at risk for recurrence, who might be candidates for further adjuvant therapies.

Cited by 48 publications

References 45 publications

Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer

Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer

Lymphangiogenic and Angiogenic Microvessel Density in Chinese Patients with Gastric Carcinoma: Correlation with Clinicopathologic Parameters and Prognosis

Prognosis in the Cancer of the Stomach

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