Significance of Atypical Glandular Cells of Undetermined Significance on ThinPrep Papanicolaou Smears

Eltabbakh, Gamal H.; Lipman, Jennifer N.; Mount, Sharon L.; Morgan, Ann W.

doi:10.1006/gyno.2000.5884

Cited by 17 publications

(20 citation statements)

References 11 publications

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“…The PPVs for the endocervical AGUS subcategories demonstrated a marked difference between the “favor neoplasia” designation and either the “unspecified” or “favor reactive” designations in both types of preparations (67% vs. 28% vs. 10% in TPs and 77% vs. 23% vs.4% in CPs). These differences are similar to those reported in other studies of biopsy follow‐up results after an AGUS interpretation in CPs,2–16 and in one similar study using TPs,20 and demonstrate that differences in PPVs among endocervical AGUS subcategories are similar in both TPs and CPs. Although the number of cases was small, we found that the AGUS “endometrial” category had a very low PPV in both groups.…”

Section: Discussionsupporting

confidence: 89%

“…It has been shown to produce well preserved thin‐layer slides devoid of the artifacts that may contribute to inaccuracies in the interpretation of conventional smears 17, 18. TPs have been shown to increase sensitivity for CIN,19 but to our knowledge there have been relatively few studies of its effectiveness in diagnosing uterine endocervical or endometrial glandular lesions 20–23. Thus, we decided to evaluate our laboratory's experience with AGUS in TP specimens.…”

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confidence: 99%

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Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations

Hecht

Sheets

Lee

2002

Cancer

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Understanding the growth pattern in Marfan syndrome is important for prediction of expected growth, prevention of excessive growth by hormone therapy, timing of surgical epiphysiodesis for cessation of growth, and instituting brace treatment for scoliosis. In this study, we analyze growth patterns and generate growth charts for persons with Marfan syndrome. From the charts of 180 clinically diagnosed Marfan patients, longitudinal height and weight measurements were obtained. From this data, growth charts and growth velocity charts were generated for males and females. Skeletal maturation was studied by determining the Risser signs from the x‐rays of 71 males and 56 females. From 22 female patients, age of menarche was available and retrieved either by reviewing the charts or contacting the patients. Mean length at birth was 53 ± 4.4 cm for males and 52.5 ± 3.5 cm for females. Mean final height was 191.3 ± 9 cm for males and 175.4 ± 8.2 cm for females. Mean birth weight was 3.51 ± 0.74 kg for males and 3.48 ± 0.68 kg for females. The puberty‐associated peak in growth velocity was 2.4 years earlier than the gender‐matched general population for males with Marfan syndrome and 2.2 years earlier for females. Age of menarche was 11.7 ± 2 years of age, which is also early compared to the general population. This study suggests that the growth spurt and pubertal skeletal maturation occur early in Marfan syndrome. The growth curves generated should help more accurately predict adult stature, as well as monitor progression toward it. © 2002 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 89%

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confidence: 99%

Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations

Hecht

Sheets

Lee

2002

Cancer

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“…The results of the current study underline the importance of mandatory follow-up of all the patients with AGC on their Pap smears. The present study and the work done by Eltabbakh and colleagues show that a good number of significant histologic findings are detected in the follow-up of patients with AGC/favoring reactive smears (26) . Therefore, this category should always be kept in mind for restricting follow-up.…”

Section: Discussionsupporting

confidence: 80%

A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran

Mood

Eftekhar

Haratian

et al. 2006

Int J Gynecol Cancer

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Atypical glandular cells (AGC) often cause diagnostic uncertainty in cervicovaginal smears. To determine the incidence of significant pathologies associated with AGC on Papanicolaou test, AGC smears were correlated with subsequent biopsy diagnoses. A retrospective review of archives of our cytology files for cervicovaginal smears diagnosed as AGC from April 1998 to March 2001 was performed. In 9390 cervicovaginal smears, AGC were reported in 76 (0.81%) cases, with histologic follow-up in 42 patients (55.3%). Twenty-two patients (52.4%) had preneoplastic or neoplastic, squamous, or glandular lesions on histologic examination. Among them were cervical intraepithelial neoplasia, basal cell abnormality of undetermined significance, cervical adenocarcinoma, endometrial hyperplasia or adenocarcinoma, vaginal adenocarcinoma, endocervical glandular dysplasia, metastatic breast carcinoma, and simple nonvillous trophoblastic tissue. Therefore, presence of AGC in cervical smears may exhibit a spectrum of findings, ranging from benign/reactive changes to squamous or glandular premalignancy or malignancy. A majority of these lesions are squamous dysplasia, and a significant number of patients had glandular malignancy. The results of the current study underline the importance of follow-up for patients with the diagnosis of AGC. To our knowledge, this is the first report in Iran showing the significance of AGC diagnosis.

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“…[17][18][19] Other studies focus on the detection of atypical glandular cells of undetermined significance, [20][21][22][23][24] an imprecise term, which is recognized to yield more high-grade squamous lesions than high-grade endocervical glandular lesions. 22,[25][26][27] The concurrent presence of cells from an HSIL did not increase the sensitivity of cervical cytology; in fact, cytologists were less likely specifically to recognize a high-grade glandular lesion.…”

Section: Discussionmentioning

confidence: 99%

Comparative sensitivities of ThinPrep and Papanicolaou smear for adenocarcinoma in situ (AIS) and combined AIS/high-grade squamous intraepithelial lesion (HSIL): Comparison with HSIL

Roberts

Thurloe²

2007

Cancer

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Significance of Atypical Glandular Cells of Undetermined Significance on ThinPrep Papanicolaou Smears

Cited by 17 publications

References 11 publications

Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations

Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations

A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran

Comparative sensitivities of ThinPrep and Papanicolaou smear for adenocarcinoma in situ (AIS) and combined AIS/high-grade squamous intraepithelial lesion (HSIL): Comparison with HSIL

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