Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations

Abstract

Understanding the growth pattern in Marfan syndrome is important for prediction of expected growth, prevention of excessive growth by hormone therapy, timing of surgical epiphysiodesis for cessation of growth, and instituting brace treatment for scoliosis. In this study, we analyze growth patterns and generate growth charts for persons with Marfan syndrome. From the charts of 180 clinically diagnosed Marfan patients, longitudinal height and weight measurements were obtained. From this data, growth charts and growth velocity charts were generated for males and females. Skeletal maturation was studied by determining the Risser signs from the x‐rays of 71 males and 56 females. From 22 female patients, age of menarche was available and retrieved either by reviewing the charts or contacting the patients. Mean length at birth was 53 ± 4.4 cm for males and 52.5 ± 3.5 cm for females. Mean final height was 191.3 ± 9 cm for males and 175.4 ± 8.2 cm for females. Mean birth weight was 3.51 ± 0.74 kg for males and 3.48 ± 0.68 kg for females. The puberty‐associated peak in growth velocity was 2.4 years earlier than the gender‐matched general population for males with Marfan syndrome and 2.2 years earlier for females. Age of menarche was 11.7 ± 2 years of age, which is also early compared to the general population. This study suggests that the growth spurt and pubertal skeletal maturation occur early in Marfan syndrome. The growth curves generated should help more accurately predict adult stature, as well as monitor progression toward it. © 2002 Wiley‐Liss, Inc.

Evidence-Based Cervical Cancer Screening: The Modern Evolution of the Pap Smear

“…Other systematic and independent reviews have reported similar findings (18,72). Observational data suggest that liquid-based samples may improve the detection of glandular lesions (73)(74)(75).…”

Comparative sensitivities of ThinPrep and Papanicolaou smear for adenocarcinoma in situ (AIS) and combined AIS/high-grade squamous intraepithelial lesion (HSIL): Comparison with HSIL

“…[17][18][19] Other studies focus on the detection of atypical glandular cells of undetermined significance, [20][21][22][23][24] an imprecise term, which is recognized to yield more high-grade squamous lesions than high-grade endocervical glandular lesions. 22,[25][26][27] The concurrent presence of cells from an HSIL did not increase the sensitivity of cervical cytology; in fact, cytologists were less likely specifically to recognize a high-grade glandular lesion. This finding was true for both the PS group and the TP group.…”

Glandular Cell Abnormalities on SurePath Preparations: A Retrospective Review with Cytology-Histology Correlations

“…Significant pathology diagnosed histologically on follow-up ranges from 9% [11] to over 60% [12] of cases. Reports comparing the performance of different preparations demonstrate inconsistent results on the prevalence of AGC, with some reporting higher rates on ThinPrep over conventional preparations [6, 13, 14] and others finding the opposite [15, 16]. There is growing convincing evidence that ThinPrep demonstrates better sensitivity, specificity, and predictive value in detecting significant glandular lesions when compared to the conventional method [3, 6, 15, 16].…”