Significance of assay of nucleated RBCs in umbilical cord blood in neonates with meconium-stained amniotic fluid

Elsokkary, M; Mamdouh, Ahmed; Nossair, Wael S.; Fattah, O Abd El; Hemeda, Hosam; Sallam, S; Taema, Mohammed; Hussain, Mohamed; Shafik, Adel; Nawara, Maii; Samy, Mohammed; Aleem, M Abd El; Abdelhadi, R; Sakna, Noha A.; Salama, A.; Salama, D.; El-Tohamy, Osama; Elsaid, Nashwa

doi:10.1080/14767058.2017.1384457

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…NRBC's/100 WBCs was highly significantly increased in group 1. Our results were in agreement with study of Elsokkary et al (8) as they reported that there were no statistically significant differences concerning cord blood WBC count and hemoglobin level. However, there were statistically highly significant differences concerning NRBC per mm 3 and NRBC per 100 WBCs with higher values in the MSAF group.…”

Section: Discussionsupporting

confidence: 93%

“…There was no significant difference regarding birth weight and sex distribution among the studied groups. In accordance with our results, the study of Elsokkary et al (8) as they included 80 women who were divided into 2 groups: Group I (n=40): included women with meconium-stained amniotic fluid. Group II (n=40): included women with clear liquor.…”

Section: Discussionsupporting

confidence: 75%

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Role of Nucleated Red Blood Cells in Diagnosis of Neonatal Asphyxia in Neonate with Meconium Stained and Clear Amniotic Fluid

Ali¹,

Khalifa²,

El-Bana³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Perinatal asphyxia has been defined as the lack of oxygen that occurs either before, during, or after birth. Many studies in recent past have suggested that an increased number of nucleated red blood cells (NRBC) in umbilical cord blood may be a useful marker to identify birth asphyxia. Objective: To find out the relationship between meconium-stained amniotic fluid and NRBC in umbilical cord blood. Patients and Methods: This was a comparative cross-section study, which was carried out at Obstetrics and Gynecology Department, Zagazig University Hospitals on 54 cases divided into 2 groups: (Group 1): included 27 pregnant females with meconium-stained amniotic fluid who gave birth to neonates (male 15 and female12) showing criteria of perinatal asphyxia, (Group 2): included 27 pregnant females with clear amniotic fluid who gave birth to neonate's apparently healthy full-term (male17 and female10) as control group with no obstetrical problems. Results: There was no statistically significant difference between case and control groups in basic characteristics or obstetric history. NRBC's/100 WBCs and lactate were highly significantly increased in group 1. The mean value of lactate was increasing in relation to stage of hypoxic ischemic encephalopathy (HIE). Conclusion:There was a strong correlation between markers of acute asphyxia (i.e., umbilical artery blood nucleated red blood cells and lactate,) and meconium-stained liquor cases. These markers were significantly elevated in newborns with meconium-stained amniotic fluid.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 75%

Role of Nucleated Red Blood Cells in Diagnosis of Neonatal Asphyxia in Neonate with Meconium Stained and Clear Amniotic Fluid

Ali¹,

Khalifa²,

El-Bana³

et al. 2022

The Egyptian Journal of Hospital Medicine

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“…Elsokkary et al compared the results of forty women with clear amniotic fluid and forty women with meconium-stained amniotic fluid. The mean number of NRBCs in the cord blood of neonates with MSAF was significantly higher than that in the control group, supporting the hypothesis that the presence of meconium may be associated with chronic fetal hypoxia [40].…”

Section: Nrbcs As An Indicator Of Hypoxia Among Neonatessupporting

confidence: 67%

Diagnostic Value and Prognostic Significance of Nucleated Red Blood Cells (NRBCs) in Selected Medical Conditions

Pikora

Krętowska-Grunwald

Krawczuk-Rybak

et al. 2023

Cells

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Nucleated red blood cells (NRBCs) are premature erythrocyte precursors that reside in the bone marrow of humans of all ages as an element of erythropoiesis. They rarely present in healthy adults’ circulatory systems but can be found circulating in fetuses and neonates. An NRBC count is a cost-effective laboratory test that is currently rarely used in everyday clinical practice; it is mostly used in the diagnosis of hematological diseases/disorders relating to erythropoiesis, anemia, or hemolysis. However, according to several studies, it may be used as a biomarker in the diagnosis and clinical outcome prognosis of preterm infants or severely ill adult patients. This would allow for a quick diagnosis of life-threatening conditions and the prediction of a possible change in a patient’s condition, especially in relation to patients in the intensive care unit. In this review, we sought to summarize the possible use of NRBCs as a prognostic marker in various disease entities. Research into the evaluation of the NRBCs in the pediatric population most often concerns neonatal hypoxia, the occurrence and consequences of asphyxia, and overall neonatal mortality. Among adults, NRBCs can be used to predict changes in clinical condition and mortality in critically ill patients, including those with sepsis, trauma, ARDS, acute pancreatitis, or severe cardiovascular disease.

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“…As the nucleated red blood cell can be associated with asphyxia or hemolytic disease, this study also verified its correlation with the ABO and RhD incompatibility and presence of variant hemoglobin, trying to exclude situations in which the NRBC is associated with a pathological condition with enhanced erythropoietin activity and does not represent the CBU proliferative condition. 12 , 13 , 14 , 15 …”

Section: Introductionmentioning

confidence: 99%

Nucleated red blood cell: a feasible quality parameter of cord blood units

Kondo

Alvarez

Cipolletta

et al. 2024

Hematology, Transfusion and Cell Therapy

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Significance of assay of nucleated RBCs in umbilical cord blood in neonates with meconium-stained amniotic fluid

Abstract: Our results support previous studies which indicate the presence of meconium can be associated with chronic fetal hypoxia as demonstrated by elevated fetal NRBC levels.

Cited by 5 publications

References 7 publications

Role of Nucleated Red Blood Cells in Diagnosis of Neonatal Asphyxia in Neonate with Meconium Stained and Clear Amniotic Fluid

Role of Nucleated Red Blood Cells in Diagnosis of Neonatal Asphyxia in Neonate with Meconium Stained and Clear Amniotic Fluid

Diagnostic Value and Prognostic Significance of Nucleated Red Blood Cells (NRBCs) in Selected Medical Conditions

Nucleated red blood cell: a feasible quality parameter of cord blood units

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