Significance of anticentromere antibody in idiopathic Raynaud's syndrome

Sarkozi, J; Bookman, Arthur; Lee, Peter; Keystone, Edward; Fritzler, Marvin J.

doi:10.1016/0002-9343(87)90647-4

Cited by 32 publications

(12 citation statements)

References 21 publications

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“…Antibodies to hnRNP I were present in all SSc subsets in our study, but were found more frequently in those patients with pre-SSc and limited SSc. The occurrence of these antibodies in patients with features of pre-SSc suggests an early appearance during the course of the disease, similar to that observed for anticentromere antibodies (17,19). No significant association between anti-hnRNP I and anticentromeric reactivity was found in our study.…”

Section: Discussionsupporting

confidence: 89%

“…Eleven additional patients had Raynaud's phenomenon, defined as cold-induced blanching and cyanosis of the fingers, and had either anticentromere antibodies or scleroderma-like nailfold capillary abnormalities (16) or both. These patients did not fulfill the ACR criteria for SSc, but were regarded as having a limited SSc or a pre-SSc condition, as previously described (17)(18)(19)(20). In the present study, these patients were classified as having pre-SSc; most of them had cutaneous teleangectasias and/or esophageal dysmotility, and 2 had primary pulmonary hypertension.…”

Section: Patents and Methodsmentioning

confidence: 99%

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Identification of autoantibodies to the I protein of the heterogeneous nuclear ribonucleoprotein complex in patients with systemic sclerosis

Montecucco

Caporali

Cobianchi

et al. 1996

Arthritis & Rheumatism

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Objective. To assess the presence of autoantibodies to the I protein (polypyrimidine‐tract binding protein) of the heterogeneous nuclear RNPs (hnRNP) in different connective tissue diseases. Antibodies to other hnRNP proteins (A1, A2, and B) have been previously found in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCTD).Methods. Sera from 101 patients with various connective tissue diseases and 25 normal controls were investigated by enzyme‐linked immunosorbent assay and immunoblotting, for their reactivity to highly purified recombinant hnRNP I. Moreover, reactivity to cellular hnRNP I protein was investigated by immunoblotting using a partially purified preparation of hnRNP proteins (including A1, A2, B, and I), and by indirect immunofluorescence. For the analysis of the fluorescence pattern, affinity‐purified antibodies to hnRNP I, obtained from a selected patient, were tested on HEp‐2 cells.Results. By immunoblotting, antibodies reacting to recombinant hnRNP I were found in 22 of 40 patients with systemic sclerosis (SSc), 3 of 32 with RA, 0 of 23 with SLE, and 0 of 6 with MCTD. Antibodies to recombinant hnRNP I were more frequently found in patients with pre‐SSc or limited SSc (15 of 24) than in those with intermediate or diffuse SSc (7 of 16). In indirect immunofluorescence studies, affinity‐purified anti—hnRNP I autoantibodies gave a diffuse nucleoplasmic staining. Using an hnRNP preparation from nuclear extracts, anti—hnRNP I reactivity was detectable in SSc sera, while it was not detectable in RA, SLE, and MCTD sera reacting with hnRNP A/B proteins.Conclusion. Human autoimmune sera show distinct patterns of anti‐hnRNP reactivity, i.e., anti‐A/B in SLE and RA sera, and anti‐I in SSc sera. This suggests that A/B proteins and the I protein may be involved in different dynamic hnRNP complexes that elicit different autoimmune responses. From a clinical perspective, anti—hnRNP I antibodies are frequently associated with pre‐SSc features, suggesting an early appearance of these antibodies during the course of the disease.

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Section: Discussionsupporting

confidence: 89%

Section: Patents and Methodsmentioning

confidence: 99%

Identification of autoantibodies to the I protein of the heterogeneous nuclear ribonucleoprotein complex in patients with systemic sclerosis

Montecucco

Caporali

Cobianchi

et al. 1996

Arthritis & Rheumatism

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“…Wealso demonstrated a positive antinuclear antibody with discrete speckled type in this case, which is identical to anticenteromere antibody. The antibody is known to be specific for the CRESTsyndrome (25-96% of the CRESTcases are anti-centromere antibody positive (13)), however, it is also known to be positive in Sjogren's syndrome (14)(15)(16), primary biliary cirrhosis (16) and idiopathic Raynaud' s syndrome (16)(17)(18) And, only Raynaud's phenomenon and calcinosis were observed in the present case although at least three symptoms of the five are needed for diagnosis as the CRESTsyndrome. Calcinosis is typically found in subcutaneous regions of hands or feet in the CRESTsyndrome, but in our case, calcinosis was not found in the hand, but colon and costal cartilage was found.…”

Section: Discussionmentioning

confidence: 62%

“…Calcinosis is typically found in subcutaneous regions of hands or feet in the CRESTsyndrome, but in our case, calcinosis was not found in the hand, but colon and costal cartilage was found. But, idiopathic Raynaud's syndrome patients have a tendency Phlebosclerosis of the Colon to switch over to the CRESTsyndrome if the anti-centromere antibody is positive (17,18). Then, it is likely that other symptoms of the CRESTsyndrome (esophageal hypomotility, sclerodactyly and telangiectasia) appear in the future.…”

Section: Discussionmentioning

confidence: 99%

Phlebosclerosis of the Colon with Positive Anti-Centromere Antibody.

et al. 1999

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A 56-year-old womanwith symptoms of chronic bowel disease presented a peculiar calcification of the mesenteric vein of the ascending to transverse colon on barium enemastudy. The resected colon was hard and black. Histo-pathologic examinations demonstrated fibrous change of the colon with a calcified and hyaline-deposited mesenteric vein. Nocell infiltration was observed. These findings were compatible with phlebosclerosis and also with systemic sclerosis. Positive anti-centromere antibody and Raynaud's phenomenon, hallmarks of a variant systemic sclerosis, the CRESTsyndrome were observed. Wetherefore speculated that the pathogenesis of the phlebosclerosis of the colon is related to the CRESTsyndrome. (Internal Medicine 38: 416-421, 1999)

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“…Autoantibodies, including antinuclear antibodies, were reported in the 1960s [7]. They can appear several years before the clinical manifestations of systemic sclerosis, which makes them very useful for evaluating recent-onset isolated Raynaud's phenomenon [8]. Among these antinuclear antibodies, anticentromere antibodies and anti-topo-I isomerase antibodies are of assistance both in making the diagnosis and in predicting the outcome [9].…”

mentioning

confidence: 99%

How useful are serum autoantibodies in the diagnosis and prognosis of systemic sclerosis?

Meyer

1998

Clin Rheumatol

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Significance of anticentromere antibody in idiopathic Raynaud's syndrome

Cited by 32 publications

References 21 publications

Identification of autoantibodies to the I protein of the heterogeneous nuclear ribonucleoprotein complex in patients with systemic sclerosis

Identification of autoantibodies to the I protein of the heterogeneous nuclear ribonucleoprotein complex in patients with systemic sclerosis

Phlebosclerosis of the Colon with Positive Anti-Centromere Antibody.

How useful are serum autoantibodies in the diagnosis and prognosis of systemic sclerosis?

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