How useful are serum autoantibodies in the diagnosis and prognosis of systemic sclerosis?

Meyer, Olivier

doi:10.1007/bf01451042

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…The prevalence of ATAs in patients with SSc was reported to be 14–71%, with a sensitivity of 24% and a specificity of 99.6% ( 1 ). ARAs were detected in 4–20% of patients, with 16% sensitivity and 97.5% specificity ( 13 ). The prevalence of ACAs in patients with SSc was 20–57.8%, with a sensitivity and specificity of 33 and 93%, respectively ( 13 , 14 ).…”

Section: Classical Disease-specific Autoantibodies In Clinical Manifementioning

confidence: 99%

“…ARAs were detected in 4–20% of patients, with 16% sensitivity and 97.5% specificity ( 13 ). The prevalence of ACAs in patients with SSc was 20–57.8%, with a sensitivity and specificity of 33 and 93%, respectively ( 13 , 14 ). However, unlike ATAs and ARAs that are rarely detected in other autoimmune diseases, ACAs may be produced in systemic lupus erythematosus, Sjögren's syndrome, rheumatoid arthritis, and primary biliary cholangitis ( 15 ).…”

Section: Classical Disease-specific Autoantibodies In Clinical Manifementioning

confidence: 99%

“…Among the classical autoantibodies, ACAs are more specific for the limited cutaneous subset of SSc (lcSSc) or CREST syndrome than ATAs ( P = 0.005, OR = 2.54, 95% CI = 0.05–0.44) ( 21 ) and ARAs ( P = 0.0005, OR = 0.13, 95% CI = 0.04–0.41); a longer disease duration before diagnosis ( 22 ) is related to good prognosis in terms of survival ( 23 ). Increased levels of ATAs are mainly associated with diffuse cutaneous disease (dcSSc) ( P < 0.0001, OR = 4.26) ( 22 ) and serious organ involvement ( 13 , 24 ). Patients with ATAs had higher SSc-related mortality rate and poor prognosis ( 25 ).…”

Section: Classical Disease-specific Autoantibodies In Clinical Manifementioning

confidence: 99%

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Classical Disease-Specific Autoantibodies in Systemic Sclerosis: Clinical Features, Gene Susceptibility, and Disease Stratification

et al. 2020

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Systemic sclerosis (SSc) is an autoimmune disease characterized by abnormalities in microcirculation, extracellular matrix accumulation, and immune activation. Autoantibodies are markers of immune abnormalities and provide diagnostic and predictive value in SSc. Anti-topoisomerase antibodies (ATAs), anticentromere antibodies (ACAs), and anti-RNA polymerase antibodies (ARAs) are the three classical specific antibodies with the highest availability and stability. In this review, we provide an overview of the recent progress in SSc research with respect to ATAs, ACAs, and ARAs, focusing on their application in distinguishing clinical phenotypes, such as malignancy and organ involvement, identifying genetic background in human leukocyte antigen (HLA) or non-HLA alleles, and their potential roles in disease pathogenesis based on the effects of antigen-antibody binding. We finally summarized the novel analysis using ATAs, ACAs, and ARAs on more detailed disease clusters. Considering these advantages, this review emphasizes that classical SSc-specific autoantibodies are still practical and have the potential for patient and risk stratification with applications in precise medicine for SSc.

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Section: Classical Disease-specific Autoantibodies In Clinical Manifementioning

confidence: 99%

Section: Classical Disease-specific Autoantibodies In Clinical Manifementioning

confidence: 99%

Section: Classical Disease-specific Autoantibodies In Clinical Manifementioning

confidence: 99%

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Classical Disease-Specific Autoantibodies in Systemic Sclerosis: Clinical Features, Gene Susceptibility, and Disease Stratification

et al. 2020

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“…ACAs are usually found in patients with limited cutaneous SSc [16] and are often associated with PAH [18]. ATAs are typically found in patients with diffuse SSc and are linked to ILD [19,20], higher SSc-related mortality rates, and poor prognosis [21]. ARAs are most associated with SRC [21].…”

Section: Introduction 1systemic Sclerosismentioning

confidence: 99%

Thyroid Disorders in Systemic Sclerosis: A Comprehensive Review

Cherim,

Petca,

Dumitrascu

et al. 2024

JCM

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Systemic sclerosis, also referred to as scleroderma, is a chronic autoimmune disease that affects both internal organs and the skin. Systemic sclerosis predominantly affects female patients and can coexist with other disorders, including those affecting the thyroid gland. Common symptoms such as fatigue and weight changes can be attributed to either systemic sclerosis or thyroid disease. In this comprehensive review, an extensive analysis is conducted using research from 2002 to 2022, sourced from PubMed. The main focus of this exploration is to understand the intricate relationship between thyroid disorders and systemic sclerosis. We obtained these results by analyzing a number of 32285 patients included in 21 original studies. The existing evidence suggests that there is a higher incidence of elevated TSH levels and hypothyroidism in patients with systemic sclerosis, particularly in females, compared to the general population. This remains true even when comparing patients from iodine-deficient regions. Additionally, there is an increased occurrence of hyperthyroidism in the context of systemic sclerosis, which negatively impacts the prognosis of these patients. Furthermore, thyroid antibodies, predominantly anti-thyroid peroxidase (anti-TPO) antibodies, and autoimmune disorders are more commonly observed in individuals with systemic sclerosis. Although thyroid nodules are not specifically linked to the disease, when considering thyroid volume, it is observed that the thyroid gland in systemic sclerosis patients has a decreased volume, possibly due to fibrosis. Conversely, other studies have revealed that patients without autoimmune thyroid diseases (AITDs) are more likely to have a history of digital ulcers, pulmonary fibrosis detected by computed tomography scan, and a requirement for immunosuppressive medication. The majority of the studies did not establish a connection between thyroid disease in these patients and the occurrence of the limited or diffuse forms of systemic sclerosis, as well as the presence of digital ulcers, calcinosis, pulmonary arterial hypertension, scleroderma renal crisis, Raynaud phenomenon, and various other clinical manifestations.

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Autoreactive B cell responses targeting nuclear antigens in systemic sclerosis: Implications for disease pathogenesis

Liem¹,

Neppelenbroek²,

Fehres³

et al. 2023

Seminars in Arthritis and Rheumatism

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How useful are serum autoantibodies in the diagnosis and prognosis of systemic sclerosis?

Cited by 4 publications

References 20 publications

Classical Disease-Specific Autoantibodies in Systemic Sclerosis: Clinical Features, Gene Susceptibility, and Disease Stratification

Classical Disease-Specific Autoantibodies in Systemic Sclerosis: Clinical Features, Gene Susceptibility, and Disease Stratification

Thyroid Disorders in Systemic Sclerosis: A Comprehensive Review

Autoreactive B cell responses targeting nuclear antigens in systemic sclerosis: Implications for disease pathogenesis

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