Significance of Anemia in Outcomes After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

McGrane, John; Humes, David J.; Acheson, Austin G; Minear, F.G.; Wheeler, James M.; Walter, C.

doi:10.1016/j.clcc.2017.03.016

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…Colorectal cancer (CRC) is frequently detected by faecal occult blood testing and strongly correlates with anaemia. Studies have assessed the prognostic or predictive value of anaemia in CRC, and have reported an association between anaemia and adverse outcomes after resection [9,10], chemotherapy [11] or radiotherapy [12]. Interestingly, anaemia has been correlated with the systemic inflammatory response [9] and serum total lymphocyte count [13], supporting the pathogenic and immunogenic influence of anaemia on cancer status.…”

Section: Introductionmentioning

confidence: 99%

The impact of preoperative anaemia and anaemic subtype on patient outcome in colorectal cancer

et al. 2018

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Section: Introductionmentioning

confidence: 99%

The impact of preoperative anaemia and anaemic subtype on patient outcome in colorectal cancer

et al. 2018

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“…The same results were also found in other studies in patients with metastatic prostate cancer (cut-off value of 32.4), pancreatic cancer (cut-off value of 44.56), small cell lung cancer (cut-off value of 25.8), and bladder cancer (cut-off value of 22.2) [ 13 - 15 , 23 ]. Previous published studies have revealed that low levels of lymphocyte, albumin, and hemoglobin were associated with poor survival in various cancers [ 24 - 26 ]. HALP was a composite index regarding the above indexes with a stronger prognostic ability.…”

Section: Discussionmentioning

confidence: 99%

The preoperative HALP score (hemoglobin, albumin, lymphocyte and platelet) is a useful predictor in patients with resectable esophageal squamous cell carcinoma

Feng

Wang

Yang

2021

Bosn J of Basic Med Sci

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The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been confirmed as a prognostic factor in several types of cancers. The current study aimed to assess the prognostic value of preoperative HALP score, an inflammatory and nutritional based score, in predicting cancer-specific survival (CSS) in resectable patients undergoing curative resection for esophageal squamous cell carcinoma (ESCC). The clinical data of 355 consecutive patients with ESCC who underwent curative resection were retrospectively conducted and analyzed. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value for preoperative HALP. The areas under the curve (AUC) for preoperative HALP and other variables were calculated and compared. Cox regression analyses and Kaplan-Meier methods were used to identify the factors associated with CSS. According to the ROC curve, the optimal cut-off value for preoperative HALP was 31.8. The 5-year CSS for preoperative HALP low (≤31.8) and high (>31.8) was 15.1% and 47.5%, respectively (p<0.001). Preoperative HALP had reliable abilities to predict CSS in resectable ESCC patients in any stage or gender, according to the subgroup analysis based on the patients' cancer stage and gender. Multivariate analyses confirmed that preoperative HALP was an independent prognostic score regarding CSS in patients with resectable ESCC (p<0.001). This study confirmed that the preoperative HALP score could be regarded as a potential independent prognostic factor for CSS in patients with resectable ESCC.

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“…The negative impact of preoperative anaemia on oncologic outcome among colorectal cancer patients after surgical resection [ 4 , 20 ], or chemotherapy or radiotherapy [ 21 , 22 ], has been described previously.…”

Section: Discussionmentioning

confidence: 99%

Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?

et al. 2021

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(1) Background: Anaemia is a common finding in patients with colon cancer and is commonly corrected by blood transfusion prior to surgery. However, the prognostic role of perioperative transfusions is still debated. The aim of the present study was to investigate the role of preoperative anaemia and preoperative blood transfusion in influencing the prognosis in colon cancer. (2) Patients and Methods: Patients undergoing elective surgery for colon cancer at a tertiary referral university hospital between January 2010 and December 2018 were included in a retrospective review of a prospectively collected database. Univariate and regression analyses were performed to identify the prognostic role of preoperative anaemia and preoperative transfusions in this homogeneous cohort of patients. (3) Results: A total of 780 patients were included in the final analysis. The estimated five-year overall survival rate was significantly worse in the anaemic group (83.8% in non-anaemic patients, 60.6% in mild anaemic patients, 61.3% in moderate anaemic patients and 58.4% in severe anaemic patients; log-rank < 0.001 vs. non-anaemic patients). Anaemic status was found to be an independent adverse prognostic factor (hazard ratio (HR): 1.46; 95% confidence interval (CI): 1.02–2.07) during multivariate analysis. Among moderate to severe anaemic patients, no significant association was found between preoperative transfusions and the risk of mortality or recurrence. (4) Conclusions: Preoperative anaemia, regardless of its severity, and not preoperative blood transfusion, was independently associated with a worse prognosis after surgery in patients with colonic cancer.

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Significance of Anemia in Outcomes After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

Cited by 22 publications

References 11 publications

The impact of preoperative anaemia and anaemic subtype on patient outcome in colorectal cancer

The impact of preoperative anaemia and anaemic subtype on patient outcome in colorectal cancer

The preoperative HALP score (hemoglobin, albumin, lymphocyte and platelet) is a useful predictor in patients with resectable esophageal squamous cell carcinoma

Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?

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