Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?

Tamini, Nicolò; Gianotti, Luca; Darwish, S.; Petitto, Salvatore; Bernasconi, Davide Paolo; Oldani, Massimo; Uggeri, Fabio; Braga, Marco; Nespoli, Luca

doi:10.3390/curroncol28060391

Cited by 2 publications

(1 citation statement)

References 27 publications

(38 reference statements)

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“…This indirectly indicated that correcting anemia prior to surgery by RBC transfusion was feasible and practical. However, several studies showed that perioperative blood transfusion was associated with worse survival in patients undergoing surgery for colorectal cancer [ 33 , 34 ]. Nevertheless, a study examining the interaction between preoperative anemia and perioperative transfusions with postoperative short-term mortality in patients undergoing gastrectomy for cancer revealed that perioperative transfusions appeared to be beneficial only for preoperative hematocrit values < 29% [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Preoperative anemia and long-term survival in patients undergoing colorectal cancer surgery: a retrospective cohort study

2023

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Background The impact of preoperative anemia on a survival outcome and the importance of correcting preoperative anemia in patients with colorectal cancer (CRC) remain controversial. This study aimed to explore how preoperative anemia affects the long-term survival of patients undergoing colorectal cancer surgery. Methods This was a retrospective cohort study in which adult patients underwent surgical resection for colorectal cancer between January 1, 2008, and December 31, 2014, at a large tertiary cancer center. A total of 7436 patients were enrolled in this study. Anemia was defined according to the diagnostic criteria of China (hemoglobin level < 110 g/L for women and < 120 g/L for men). The median follow-up time was 120.5 months (10.0 years). Inverse probability of treatment weighting (IPTW) using the propensity score was used to reduce selection bias. Overall survival (OS) and disease-free survival (DFS) were compared between patients with and without preoperative anemia using the Kaplan–Meier estimator and the weighted log-rank test based on IPTW. Univariate and multivariate Cox proportional hazards models were used to assess factors associated with OS and DFS. Multivariable Cox regression was also used to assess red blood cell (RBC) transfusion associations between preoperative anemia and outcomes. Results After IPTW adjustment, clinical profiles were similar, except that tumor location and TNM stage remained imbalanced between the preoperative anemia and preoperative non-anemia groups (p < 0.001). IPTW analysis showed that the 5-year OS rate (71.3 vs. 78.6%, p < 0.001) and the 5-year DFS rate (63.9 vs. 70.9%, p < 0.001) were significantly lower in the preoperative anemia group. Multivariate analysis showed that preoperative anemia was associated with poorer OS and DFS, while RBC transfusion may improve OS (hazard ratio [HR] 0.54, p = 0.054) and DFS (HR 0.50, p = 0.020) in CRC patients with preoperative anemia. Conclusions Preoperative anemia is an independent risk factor for survival in patients undergoing colorectal surgery. Strategies to reduce preoperative anemia in patients with CRC should be considered.

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Section: Discussionmentioning

confidence: 99%

Preoperative anemia and long-term survival in patients undergoing colorectal cancer surgery: a retrospective cohort study

2023

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Risk Factors for Severe Postoperative Complications after Oncologic Right Colectomy: Unicenter Analysis

Zarnescu

Sanda

et al. 2022

Medicina

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Background and Objectives: This study aimed to investigate the potential risk factors for severe postoperative complications after oncologic right colectomy. Materials and Methods: All consecutive patients with right colon cancer who underwent right colectomy in our department between 2016 and 2021 were retrospectively included in this study. The Clavien–Dindo grading system was used to evaluate postoperative complications. Univariate and multivariate logistic regression analyses were used to investigate risk factors for postoperative severe complications. Results: Of the 144 patients, there were 69 males and 75 females, with a median age of 69 (IQR 60–78). Postoperative morbidity and mortality rates were 41.7% (60 patients) and 11.1% (16 patients), respectively. The anastomotic leak rate was 5.3% (7 patients). Severe postoperative complications (Clavien–Dindo grades III–V) were present in 20 patients (13.9%). Univariate analysis showed the following as risk factors for postoperative severe complications: Charlson score, lack of mechanical bowel preparation, level of preoperative proteins, blood transfusions, and degree of urgency (elective/emergency right colectomy). In the logistic binary regression, the Charlson score (OR = 1.931, 95% CI = 1.077–3.463, p = 0.025) and preoperative protein level (OR = 0.049, 95% CI = 0.006–0.433, p = 0.007) were found to be independent risk factors for postoperative severe complications. Conclusions: Severe complications after oncologic right colectomy are associated with a low preoperative protein level and a higher Charlson comorbidity index.

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Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?

Cited by 2 publications

References 27 publications

Preoperative anemia and long-term survival in patients undergoing colorectal cancer surgery: a retrospective cohort study

Preoperative anemia and long-term survival in patients undergoing colorectal cancer surgery: a retrospective cohort study

Risk Factors for Severe Postoperative Complications after Oncologic Right Colectomy: Unicenter Analysis

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